Review
Critical Care Medicine
Abdelaziz Farhat, Ryan Ruiyang Ling, Christopher L. Jenks, Wynne Hsing Poon, Isabelle Xiaorui Yang, Xilong Li, Yulun Liu, Cindy Darnell-Bowens, Kollengode Ramanathan, Ravi R. Thiagarajan, Lakshmi Raman
Summary: The study revealed a rapid expansion in the use of extracorporeal cardiopulmonary resuscitation in pediatric patients, with an overall survival rate of 46% and a 30% rate of favorable neurologic outcomes.
CRITICAL CARE MEDICINE
(2021)
Article
Medicine, Research & Experimental
Tai Yin, Lance B. Becker, Rishabh C. Choudhary, Ryosuke Takegawa, Muhammad Shoaib, Koichiro Shinozaki, Yusuke Endo, Koichiro Homma, Daniel M. Rolston, Shuhei Eguchi, Tadashi Ariyoshi, Asami Matsumoto, Kentaro Oka, Motomichi Takahashi, Tomoaki Aoki, Santiago J. Miyara, Mitsuaki Nishikimi, Junichi Sasaki, Junhwan Kim, Ernesto P. Molmenti, Kei Hayashida
Summary: This study demonstrated that the combination of H-2 gas with ECPR therapy improved survival rates in rats after CA/ECPR, enhanced brain electrical activity recovery, and alleviated endothelial damage. H-2 treatment also significantly improved brain tissue oxygenation during resuscitation and prevented an increase in central venous pressure post-ECPR.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Review
Critical Care Medicine
Mathias J. Holmberg, Asger Granfeldt, Anne-Marie Guerguerian, Claudio Sandroni, Cindy H. Hsu, Ryan M. Gardner, Peter C. Lind, Mark A. Eggertsen, Cecilie M. Johannsen, Lars W. Andersen
Summary: This article is a systematic review that compares the use of extracorporeal cardiopulmonary resuscitation (ECPR) with manual or mechanical cardiopulmonary resuscitation during cardiac arrest. The recent randomized trials suggest a potential benefit of ECPR, but the certainty of evidence remains low, and it is unclear which patients might benefit from ECPR.
Article
Cardiac & Cardiovascular Systems
James F. V. Howick, Joshua A. Rezkalla, Thomas Tilbury, Sunil V. Mankad, Courtney E. Bennett, Joerg Herrmann, Gregory Barsness, Stephen M. Ansell, Matthew D. Read
Summary: Venoarterial extracorporeal membrane oxygenation (VA-ECMO) provides temporary mechanical circulatory support and simultaneous extracorporeal gas exchange for acute cardiorespiratory failure. In this case report, VA-ECMO/extracorporeal cardiopulmonary resuscitation was used in a patient with recurrent lymphoma and recent autologous stem cell transplant after cardiac arrest with pulseless electrical activity.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
George Gill, Jignesh K. Patel, Diego Casali, Georgina Rowe, Hongdao Meng, Dominick Megna, Joanna Chikwe, Puja B. Parikh
Summary: Factors such as age, gender, income level, presence of ventricular arrhythmia, undergoing percutaneous coronary intervention, and use of therapeutic hypothermia were found to be independently associated with mortality in patients with cardiac arrest receiving ECMO. Identification of these predictors could help in decision-making regarding the implementation of ECMO in this population. Further larger-scale studies are needed to assess appropriate candidates for ECMO in cardiac arrest.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Review
Multidisciplinary Sciences
Tom P. Aufderheide, Rajat Kalra, Marinos Kosmopoulos, Jason A. Bartos, Demetris Yannopoulos
Summary: Extracorporeal cardiopulmonary resuscitation (ECPR) is a new method targeting out-of-hospital cardiac arrest cases that combines standard CPR with VA-ECMO and coronary artery revascularization, showing improved survival and neurological outcomes despite prolonged CPR duration.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2022)
Review
Critical Care Medicine
Darryl Abrams, Graeme MacLaren, Roberto Lorusso, Susanna Price, Demetris Yannopoulos, Leen Vercaemst, Jan Belohlavek, Fabio S. Taccone, Nadia Aissaoui, Kiran Shekar, A. Reshad Garan, Nir Uriel, Joseph E. Tonna, Jae Seung Jung, Koji Takeda, Yih-Sharng Chen, Arthur S. Slutsky, Alain Combes, Daniel Brodie
Summary: Extracorporeal cardiopulmonary resuscitation (ECPR) is emerging as a promising modality to improve survival rates for both in-hospital and out-of-hospital cardiac arrest, but its implementation requires significant resources and may burden healthcare systems, clinicians, patients, and families. Studies show that ECPR is beneficial for in-hospital cardiac arrest, and recent randomized controlled trials also suggest its feasibility for out-of-hospital cardiac arrest.
INTENSIVE CARE MEDICINE
(2022)
Article
Anesthesiology
Christopher Lotz, Ralf M. Muellenbach, Peter Spieth
Summary: eCPR can improve neurological outcomes and quality of life for survivors of cardiac arrest, but should only be performed by experienced teams to minimize procedure-related complications and ethical issues.
MINERVA ANESTESIOLOGICA
(2021)
Article
Multidisciplinary Sciences
Jun Nakajima, Yusuke Sawada, Yuta Isshiki, Yumi Ichikawa, Kazunori Fukushima, Yuto Aramaki, Kiyohiro Oshima
Summary: The prehospital administered dosage of epinephrine influences the plasma levels of Ep, but does not contribute to the plasma levels of norepinephrine (Nep), dopamine (DOA) and vasopressin (ADH) in patients with out-of-hospital cardiac arrest (OHCA).
Review
Medicine, General & Internal
Lars J. Bjertnaes, Kristian Hindberg, Torvind O. Naesheim, Evgeny V. Suborov, Eirik Reierth, Mikhail Y. Kirov, Konstantin M. Lebedinskii, Torkjel Tveita
Summary: This systematic review and meta-analysis compared outcomes of rewarming after accidental hypothermic cardiac arrest with CPB or/and ECMO, finding that survival rate was significantly higher with ECMO than CPB, and for witnessed compared to unwitnessed cases, with avalanche victims having the lowest survival probability. Male sex, high initial body temperature, low pH, and high s-K+ levels were associated with lower chances of surviving.
FRONTIERS IN MEDICINE
(2021)
Letter
Medicine, General & Internal
Olivier C. Manintveld, Stefan Roest, Yannick J. H. J. Taverne
Summary: In the study by Suverein et al., the use of extracorporeal cardiopulmonary resuscitation (CPR) in patients with refractory out-of-hospital cardiac arrest was examined. The results showed similar survival rates with a favorable neurologic outcome between extracorporeal CPR and conventional CPR. This raises questions about the role of extracorporeal CPR as an adjunct to conventional CPR.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Medicine, Research & Experimental
Patrick Bernhard, Berit Amelie Bretthauer, Sam Joe Brixius, Hannah Buegener, Johannes Elias Groh, Christian Scherer, Domagoj Damjanovic, Joerg Haberstroh, Georg Trummer, Christoph Benk, Friedhelm Beyersdorf, Oliver Schilling, Jan-Steffen Pooth
Summary: This study investigated the effects of cardiac arrest (CA), conventional cardiopulmonary resuscitation (CPR), and extracorporeal cardiopulmonary resuscitation (ECPR) on the serum proteome profiles in a pig model. The results showed significant changes in the serum proteome during resuscitation, including haemolysis, coagulation, inflammation, and cell-death processes. These findings contribute to a better understanding of the underlying mechanisms and may help improve therapeutic options for CA and resuscitation.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Review
Medicine, General & Internal
Nitish Sood, Anish Sangari, Arnav Goyal, J. Arden S. Conway
Summary: A systematic review and meta-analysis was conducted to examine the predictors of survival in pediatric patients undergoing extracorporeal cardiopulmonary resuscitation (ECPR). The study identified several significant predictors, including pre-ECPR laboratory measurements, comorbidities, ECPR characteristics, and post-ECPR complications. These predictors can help clinicians assess prognosis, select appropriate patients, and improve the effectiveness of ECPR programs.
Review
Medicine, General & Internal
Wachira Wongtanasarasin, Karan Srisurapanont, Daniel K. Nishijima
Summary: Current guidelines recommend administering 1 mg of epinephrine every 3-5 min for cardiac arrest treatment. This study aimed to investigate the impact of different epinephrine administration intervals on resuscitation outcomes in adult patients. Three high-quality studies were included in the systematic review. The results showed that the administration interval of epinephrine during CPR was not associated with better hospital outcomes.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Critical Care Medicine
James W. Schurr, Mohammad Noubani, Lee Ann Santore, Andrew P. Rabenstein, Kathleen Dhundale, Jillian Fitzgerald, Jan Cahill, Thomas Bilfinger, Frank C. Seifert, Allison J. McLarty
Summary: This study evaluated the use of ECMO in cardiac arrest patients, finding that BMI, RRT, and tracheostomy are predictors of in-hospital survival, and that mSAVE score and BMI are predictors of favorable neurologic outcomes.
