期刊
MOLECULAR SYSTEMS BIOLOGY
卷 12, 期 4, 页码 -出版社
WILEY
DOI: 10.15252/msb.20156484
关键词
Cross-species complementation; Network evolution; Selection
资金
- National Human Genome Research Institute (NHGRI) [R01-HG006061, R01-HG001715]
- National Science Foundation (NSF) [CCF-1219007]
- Natural Sciences and Engineering Research Council of Canada (NSERC) [RGPIN-2014-03892]
- Canada Foundation for Innovation (CFI) [JELF-33732]
- Canada Research Chairs Program
- Canada Excellence Research Chairs Program
- Krembil Foundation
- Ontario Research Fund
- Direct For Computer & Info Scie & Enginr
- Division of Computing and Communication Foundations [1219007] Funding Source: National Science Foundation
- ICREA Funding Source: Custom
In cellular systems, biophysical interactions between macromolecules underlie a complex web of functional interactions. How biophysical and functional networks are coordinated, whether all biophysical interactions correspond to functional interactions, and how such biophysical-versus-functional network coordination is shaped by evolutionary forces are all largely unanswered questions. Here, we investigate these questions using an interinteractome approach. We systematically probed the yeast and human proteomes for interactions between proteins from these two species and functionally characterized the resulting inter-interactome network. After a billion years of evolutionary divergence, the yeast and human proteomes are still capable of forming a biophysical network with properties that resemble those of intra-species networks. Although substantially reduced relative to intra-species networks, the levels of functional overlap in the yeast-human inter-interactome network uncover significant remnants of co-functionality widely preserved in the two proteomes beyond human-yeast homologs. Our data support evolutionary selection against biophysical interactions between proteins with little or no co-functionality. Such non-functional interactions, however, represent a reservoir from which nascent functional interactions may arise.
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