Metabolic and epigenetic reprogramming in the pathogenesis of glioblastoma: Toward the establishment of “metabolism‐based pathology”

Recurrent high‐grade astrocytoma with somatic mosaicism of isocitrate dehydrogenase gene mutation

(2023) Kenta Masui et al.   PATHOLOGY INTERNATIONAL

A case of “genetically defined” radiation‐induced glioma: 29 years after surgery and radiation for pilocytic astrocytoma

(2023) Kenta Masui et al.   NEUROPATHOLOGY

Vorasidenib in IDH1- or IDH2-Mutant Low-Grade Glioma

(2023) Ingo K. Mellinghoff et al.   NEW ENGLAND JOURNAL OF MEDICINE

MIXTURE of human expertise and deep learning—developing an explainable model for predicting pathological diagnosis and survival in patients with interstitial lung disease

(2022) Wataru Uegami et al.   MODERN PATHOLOGY

Maximum 11C-methionine PET uptake as a prognostic imaging biomarker for newly diagnosed and untreated astrocytic glioma

(2022) Kosuke Nakajo et al.   Scientific Reports

The metabolomic landscape plays a critical role in glioma oncogenesis

(2022) Kenta Masui et al.   CANCER SCIENCE

The central role of mTORC1 in amino acid sensing

(2022) Shusheng Yue et al.   CANCER RESEARCH

Oncometabolite in Cancer: Current Understanding and Challenges

(2021) Yang Liu et al.   CANCER RESEARCH

Metabolic Reprogramming Drives Pituitary Tumor Growth through Epigenetic Regulation of TERT

(2021) Hiromi Onizuka et al.   ACTA HISTOCHEMICA ET CYTOCHEMICA

The implications of IDH mutations for cancer development and therapy

(2021) Christopher J. Pirozzi et al.   Nature Reviews Clinical Oncology

The 2021 WHO Classification of Tumors of the Central Nervous System: a summary

(2021) David N Louis et al.   NEURO-ONCOLOGY

Codependency of Metabolism and Epigenetics Drives Cancer Progression: A Review

(2020) Kenta Masui et al.   ACTA HISTOCHEMICA ET CYTOCHEMICA

Dual Regulation of Histone Methylation by mTOR Complexes Controls Glioblastoma Tumor Cell Growth via EZH2 and SAM

(2020) Mio Harachi et al.   MOLECULAR CANCER RESEARCH

Synaptic input to brain tumors: clinical implications

(2020) Varun Venkataramani et al.   NEURO-ONCOLOGY

Reduced H3K27me3 levels in diffuse gliomas: association with 1p/19q codeletion and difference from H3K27me3 loss in malignant peripheral nerve sheath tumors

(2020) Keiichiro Kitahama et al.   Brain Tumor Pathology

Oncometabolites in cancer aggressiveness and tumour repopulation

(2019) Ilaria Dando et al.   BIOLOGICAL REVIEWS

Glutamate Receptors and Glioblastoma Multiforme: An Old “Route” for New Perspectives

(2019) Lorenzo Corsi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The landscape of cancer cell line metabolism

(2019) Haoxin Li et al.   NATURE MEDICINE

Histone H3 tail binds a unique sensing pocket in EZH2 to activate the PRC2 methyltransferase

(2019) Krupa S. Jani et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Impact of One Carbon Metabolism on Histone Methylation

(2019) Magdalini Serefidou et al.   Frontiers in Genetics

mTORC2 links growth factor signaling with epigenetic regulation of iron metabolism in glioblastoma

(2019) Kenta Masui et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Acetyl-CoA promotes glioblastoma cell adhesion and migration through Ca2+–NFAT signaling

(2018) Joyce V. Lee et al.   GENES & DEVELOPMENT

DNA methylation-based classification of central nervous system tumours

(2018) David Capper et al.   NATURE

Concordant association validates MGMT methylation and protein expression as favorable prognostic factors in glioma patients on alkylating chemotherapy (Temozolomide)

(2018) Arshad A. Pandith et al.   Scientific Reports

cIMPACT-NOW update 3: recommended diagnostic criteria for “Diffuse astrocytic glioma, IDH-wildtype, with molecular features of glioblastoma, WHO grade IV”

(2018) Daniel J. Brat et al.   ACTA NEUROPATHOLOGICA

Histone Modifications: Insights into Their Influence on Gene Expression

(2018) Bruce Stillman   CELL

The DNA methylation landscape of glioblastoma disease progression shows extensive heterogeneity in time and space

(2018) Johanna Klughammer et al.   NATURE MEDICINE

Reciprocal Regulation of Metabolic Reprogramming and Epigenetic Modifications in Cancer

(2018) Xilan Yu et al.   Frontiers in Genetics

mTOR as a central hub of nutrient signalling and cell growth

(2018) Joungmok Kim et al.   NATURE CELL BIOLOGY

mTORC2 Regulates Amino Acid Metabolism in Cancer by Phosphorylation of the Cystine-Glutamate Antiporter xCT

(2017) Yuchao Gu et al.   MOLECULAR CELL

mTORC2 activity in brain cancer: Extracellular nutrients are required to maintain oncogenic signaling

(2016) Kenta Masui et al.   BIOESSAYS

Molecular Profiling Reveals Biologically Discrete Subsets and Pathways of Progression in Diffuse Glioma

(2016) Michele Ceccarelli et al.   CELL

Metabolic Heterogeneity in Human Lung Tumors

(2016) Christopher T. Hensley et al.   CELL

The Emerging Hallmarks of Cancer Metabolism

(2016) Natalya N. Pavlova et al.   Cell Metabolism

Cancer metabolism: a therapeutic perspective

(2016) Ubaldo E. Martinez-Outschoorn et al.   Nature Reviews Clinical Oncology

Preferential Iron Trafficking Characterizes Glioblastoma Stem-like Cells

(2015) David L. Schonberg et al.   CANCER CELL

Insulator dysfunction and oncogene activation in IDH mutant gliomas

(2015) William A. Flavahan et al.   NATURE

Metabolic reprogramming in glioblastoma: the influence of cancer metabolism on epigenetics and unanswered questions

(2015) Sameer Agnihotri et al.   NEURO-ONCOLOGY

Glucose-dependent acetylation of Rictor promotes targeted cancer therapy resistance

(2015) Kenta Masui et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Acetate Is a Bioenergetic Substrate for Human Glioblastoma and Brain Metastases

(2014) Tomoyuki Mashimo et al.   CELL

mTORC2 dictates Warburg effect and drug resistance

(2014) Kenta Masui et al.   CELL CYCLE

Influence of Metabolism on Epigenetics and Disease

(2013) William G. Kaelin et al.   CELL

The Somatic Genomic Landscape of Glioblastoma

(2013) Cameron W. Brennan et al.   CELL

EGFR Mutation-Induced Alternative Splicing of Max Contributes to Growth of Glycolytic Tumors in Brain Cancer

(2013) Ivan Babic et al.   Cell Metabolism

mTOR Complex 2 Controls Glycolytic Metabolism in Glioblastoma through FoxO Acetylation and Upregulation of c-Myc

(2013) Kenta Masui et al.   Cell Metabolism

Targeted Therapy Resistance Mediated by Dynamic Regulation of Extrachromosomal Mutant EGFR DNA

(2013) David A. Nathanson et al.   SCIENCE

IDH mutation impairs histone demethylation and results in a block to cell differentiation

(2012) Chao Lu et al.   NATURE

2-hydroxyglutarate detection by magnetic resonance spectroscopy in IDH-mutated patients with gliomas

(2012) Changho Choi et al.   NATURE MEDICINE

Oncometabolite 2-Hydroxyglutarate Is a Competitive Inhibitor of α-Ketoglutarate-Dependent Dioxygenases

(2011) Wei Xu et al.   CANCER CELL

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

The Global DNA Methylation Surrogate LINE-1 Methylation Is Correlated with MGMT Promoter Methylation and Is a Better Prognostic Factor for Glioma

(2011) Fumiharu Ohka et al.   PLoS One

Metabolic state of glioma stem cells and nontumorigenic cells

(2011) E. Vlashi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of a CpG Island Methylator Phenotype that Defines a Distinct Subgroup of Glioma

(2010) Houtan Noushmehr et al.   CANCER CELL

Glial progenitors in the brainstem give rise to malignant gliomas by platelet-derived growth factor stimulation

(2010) Kenta Masui et al.   GLIA

PDGF stimulates the massive expansion of glial progenitors in the neonatal forebrain

(2009) M. C. Assanah et al.   GLIA

Comprehensive genomic characterization defines human glioblastoma genes and core pathways

(2008) Roger McLendon et al.   NATURE