4.2 Article

Highly Ozonated Sunflower Oil Dose May Cause Oxidative Stress and Impact the Quality of Life After Palatal Graft Removal: Secondary Endpoints of a Randomized Controlled Clinical Trial

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OZONE-SCIENCE & ENGINEERING
卷 -, 期 -, 页码 -

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TAYLOR & FRANCIS INC
DOI: 10.1080/01919512.2023.2253261

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Health-related quality of life; ozone; pain; periodontics; wound healing

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The aim of this study was to evaluate the impact of highly ozonated sunflower oil on postoperative pain and quality of life in the palate donor area of free gingival graft. The results showed that participants in the test group, who were treated with ozonated sunflower oil, reported a worse quality of life compared to those in the control group. MDA levels were also higher in the test group, indicating that the over application of ozonated sunflower oil had a negative impact on quality of life.
The aim of this work was to evaluate the effect if the highly ozonated sunflower oil on postoperative pain and quality of life in the palate donor area of free gingival graft (FGG). After graft removal, the palatal wound was treated with ozonated sunflower oil with a peroxide index between 510 and 625 meq/kg in the test group (n = 14) and with non-ozonated sunflower oil in the control group (n = 14). These are the secondary endpoints of a randomized clinical trial. Questionnaires assessing oral health impact on quality of life (OHIP-14) and postoperative pain (VAS scale) were applied to all participants at day 7. The results did not reveal a statistically significant difference in the postoperative pain between groups in all periods (P>0.05). There was a significant positive correlation in both groups for pain and amount of analgesic consumption (P<0.0001). It was found that participants in the test group reported a worse quality of life than those in the control group (P<0.05), with impact on unsatisfactory diet, meal interruptions, and irritability (P<0.05). MDA levels measured 7 days post-treatment were higher in the test group compared to those of the control group (P < 0.05). It can be concluded that high dose and over application of the ozonated sunflower oil had a negative impact on the quality of life of individuals after palatal graft removal caused by oxidative stress.

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