期刊
MOLECULAR PSYCHIATRY
卷 23, 期 2, 页码 240-246出版社
SPRINGERNATURE
DOI: 10.1038/mp.2016.213
关键词
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资金
- Erasmus Medical Centre, Rotterdam
- Netherlands Organization for Health Research and Development
- Netherlands Organization for Health Research and Development [ZonMw-VIDI016.136.361]
- European Research Council [ERC-2014-CoG-648916]
- National Health and Medical Research Council [NHMRC APP1062846]
- FP7 Nutrimenthe [212652]
- NHMRC John Cade Fellowship [APP1056929]
- Erasmus University Rotterdam
There is intense interest in identifying modifiable risk factors associated with autism-spectrum disorders (ASD). Autism-related traits, which can be assessed in a continuous fashion, share risk factors with ASD, and thus can serve as informative phenotypes in population-based cohort studies. Based on the growing body of research linking gestational vitamin D deficiency with altered brain development, this common exposure is a candidate modifiable risk factor for ASD and autism-related traits. The association between gestational vitamin D deficiency and a continuous measure of autism-related traits at similar to 6 years (Social Responsiveness Scale; SRS) was determined in a large population-based cohort of mothers and their children (n = 4229). 25-hydroxyvitamin D (25OHD) was assessed from maternal mid-gestation sera and from neonatal sera (collected from cord blood). Vitamin D deficiency was defined as 25OHD concentrations less than 25 nmol l(-1). Compared with the 25OHD sufficient group (25OHD>50 nmol l(-1)), those who were 25OHD deficient had significantly higher (more abnormal) SRS scores (mid-gestation n = 2866, beta = 0.06, P<0.001; cord blood n = 1712, beta = 0.03, P = 0.01). The findings persisted (a) when we restricted the models to offspring with European ancestry, (b) when we adjusted for sample structure using genetic data, (c) when 25OHD was entered as a continuous measure in the models and (d) when we corrected for the effect of season of blood sampling. Gestational vitamin D deficiency was associated with autism-related traits in a large population-based sample. Because gestational vitamin D deficiency is readily preventable with safe, cheap and accessible supplements, this candidate risk factor warrants closer scrutiny.
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