Review
Biochemistry & Molecular Biology
Felix Klawitter, Johannes Ehler, Rika Bajorat, Robert Patejdl
Summary: Mitochondria play a crucial role in providing energy and participating in metabolism and signaling processes. However, mitochondrial dysfunction in critical illness can lead to organ failure and muscle wasting. This review aims to discuss the molecular mechanisms underlying mitochondrial dysfunction in intensive care unit-acquired weakness and critical illness myopathy, and its implications for muscle function and potential therapeutic approaches.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Geriatrics & Gerontology
Alex B. Addinsall, Nicola Cacciani, Anders Backeus, Yvette Hedstrom, Ganna Shevchenko, Jonas Bergquist, Lars Larsson
Summary: This study found that chronic supramaximal electrical stimulation (ES) can alleviate the symptoms of critical illness myopathy (CIM) and maintain muscle glucose homeostasis by increasing the AMPK-TBC1D4 signaling pathway, reducing muscle protein degradation.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2022)
Article
Geriatrics & Gerontology
Lingling Xie, Jiaojiao Jiang, Hongbo Fu, Wenyi Zhang, Ling Yang, Ming Yang
Summary: This study aimed to explore the associations of Global Leadership Initiative on Malnutrition (GLIM)-defined malnutrition with muscle mass, muscle quality, and muscle strength in hospitalized older adults.
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
(2022)
Article
Geriatrics & Gerontology
Jie Dong, Jie Yu, Zekun Li, Song Gao, Hongwei Wang, Shengyu Yang, Liangliang Wu, Chungen Lan, Tiansuo Zhao, Chuntao Gao, Zhe Liu, Xiuchao Wang, Jihui Hao
Summary: This study demonstrates a significant correlation between serum IGFBP2 levels, malnutrition, and muscle atrophy in PDAC. The results suggest that serum IGFBP2 level might serve as a promising biomarker and intervention target for severe malnutrition and muscle wasting associated with PDAC.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2021)
Review
Nutrition & Dietetics
Giuseppe Aprile, Debora Basile, Renato Giaretta, Gessica Schiavo, Nicla La Verde, Ettore Corradi, Taira Monge, Francesco Agustoni, Silvia Stragliotto
Summary: Understanding and addressing malnutrition and muscle wasting in cancer patients is crucial for improving treatment outcomes, with early nutritional assessment playing a key role in preventing treatment-induced toxicities and enhancing survival rates.
Review
Critical Care Medicine
Brigitta Fazzini, Tobias Maerkl, Christos Costas, Manfred Blobner, Stefan J. Schaller, John Prowle, Zudin Puthucheary, Henning Wackerhage
Summary: The aim of this study was to synthesize data on the rate of muscle loss in critically ill patients and identify the methods used to measure muscle size. The study found that critically ill patients lose nearly 2% of skeletal muscle per day during the first week of ICU admission. The overall prevalence of ICU-acquired weakness was 48%.
Review
Geriatrics & Gerontology
Patrick Casey, Mohamed Alasmar, John McLaughlin, Yeng Ang, Jamie McPhee, Priam Heire, Javed Sultan
Summary: Ultrasound is a promising tool for measuring skeletal muscle mass and quality, and can predict functional capacity, clinical outcomes, and survival. However, further standardization is needed before ultrasound can be widely used in nutritionally vulnerable patients.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2022)
Article
Critical Care Medicine
Xiancheng Chen, Xiaojing Li, Huimin Lu, Yali Xu, Yu Wei, Ke Cao, Zhanghua Zhu, Ming Chen, Wenkui Yu
Summary: PIICS poses a growing challenge in ICUs, and we established a mouse model to study the disease's pathophysiology and treatment. The model shows two mortality peaks and a protracted course of 14 days, indicating a re-aggravated status compared to previous models.
Review
Immunology
Olga Maria Nardone, Roberto de Sire, Valentina Petito, Anna Testa, Guido Villani, Franco Scaldaferri, Fabiana Castiglione
Summary: Sarcopenia, characterized by muscle mass and function loss, poses a significant health burden in industrialized countries. Factors such as aging, inflammation, mitochondrial dysfunction, and insulin resistance contribute to its pathogenesis. Recent studies show that gut microbiota play a crucial role in the development of muscle failure in inflammatory bowel disease patients.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Public, Environmental & Occupational Health
Shela Sridhar, Janella S. Kang, Isabel Madzorera, Ethan Zulu, Joyce Makasa, Sally Bell Cross, Davidson H. Hamer
Summary: Understanding the prevalence of malnutrition in older children and adolescents is crucial for addressing food insecurity and undernutrition at all age groups. This study aimed to investigate the nutritional status of adolescents and older children in Zambia and explore the impact of food security.
FRONTIERS IN PUBLIC HEALTH
(2023)
Review
Nutrition & Dietetics
Antia Fernandez-Pombo, Gemma Rodriguez-Carnero, Ana I. Castro, Ana Canton-Blanco, Luisa M. Seoane, Felipe F. Casanueva, Ana B. Crujeiras, Miguel A. Martinez-Olmos
Summary: Chronic heart failure often leads to involuntary weight loss and muscle wasting, necessitating careful nutritional evaluation and treatment to prevent or improve cardiac cachexia and sarcopenia, as well as improve the course of the disease.
CLINICAL NUTRITION
(2021)
Article
Oncology
Emma J. Verwaaijen, Annelienke M. van Hulst, Annelies Hartman, Rob Pieters, Marta Fiocco, Saskia M. F. Pluijm, Raphaele R. L. van Litsenburg, Martha A. Grootenhuis, Erica L. T. van den Akker, Marry M. van den Heuvel-Eibrink
Summary: Dexamethasone treatment for pediatric acute lymphoblastic leukemia (ALL) can lead to muscle atrophy and increase the risk of physical frailty. This study found that the proportion of patients with frailty significantly increased after a 5-day dexamethasone course, while the proportions of sarcopenia and prefrailty remained similar. Lower appendicular skeletal muscle mass, weaker muscle strength, and less physical activity minutes per day increased the risk of frailty, while slower walking performance also increased the risk.
Article
Critical Care Medicine
T. S. O. Jameson, M. K. Caldow, F. Stephens, L. Denehy, G. S. Lynch, R. Koopman, A. Krajcova, T. Urban, S. Berney, F. Duska, Z. Puthucheary
Summary: Critically ill patients often experience acute muscle wasting, leading to physical functional impairment. Functional electrical stimulation-assisted exercise does not improve muscle wasting and physical functional impairment.
Review
Nutrition & Dietetics
N. A. Costa, M. F. Minicucci, A. G. Pereira, S. A. R. de Paiva, M. P. Okoshi, B. F. Polegato, L. A. M. Zornoff, P. J. F. Villas Boas, P. J. Atherton, B. E. Phillips, J. Banerjee, A. L. Gordon, P. S. Azevedo
Summary: Up to half of ICU survivors may experience residual functional and/or cognitive impairment; assessing frailty status could be an important complementary approach in clinical practice.
CLINICAL NUTRITION
(2021)
Article
Geriatrics & Gerontology
Celine Demonceau, Fanny Buckinx, Jean-Yves Reginster, Olivier Bruyere
Summary: This study investigated the relationships between frailty, nutritional status, muscle strength, and the incidence and severity of Covid-19 in nursing home residents. The results showed that after adjusting for covariates, there was no association between frailty, nutritional status, grip strength, and the incidence and severity of Covid-19.
Article
Nutrition & Dietetics
Hulya Ulusoy, Melda Kangalgil, Ahmet Oguzhan Kucuk, Asiye Ozdemir, Suleyman Caner Karahan, Serap Ozer Yaman, Hatice Bozkurt Yavuz, Umitcan Ok
Summary: This study aimed to investigate the effects of different lipid emulsions on changes in concentrations of adipokines and cytokines and their relationship with mortality in critically ill patients with sepsis. The results showed that serum leptin, resistin, and certain cytokines decreased significantly over ten days following sepsis, and there were associations between survival and changes in adiponectin, resistin, and visfatin concentrations.
CLINICAL NUTRITION
(2021)
Article
Anesthesiology
Mehtap Pehlivanlar Kucuk, Cagatay Erman Ozturk, Nazan Koylu Ilkaya, Ahmet Oguzhan Kucuk, Dursun Firat Ergul, Fatma Ulger
Summary: The study investigated the use of early APRV mode as a lung protective strategy compared to conventional methods in preventing ARDS development. The results showed that APRV mode was associated with improved oxygenation, higher mean airway pressures, and shorter intensive care unit stay, but did not reduce sedation requirement, ARDS development, or mortality.
BRAZILIAN JOURNAL OF ANESTHESIOLOGY
(2022)
Article
Obstetrics & Gynecology
Melda Kangalgil, Ayhan Sahinler, Ayse Ozfer Ozcelik
Summary: The study aimed to examine the associations between maternal serum folate, ferritin, and vitamin B-12 status and maternal and dietary factors. The results showed significant associations between maternal serum status and maternal characteristics, dietary intakes, and total nutrient intake. The findings suggest that folic acid supplementation is important for optimal serum folate status during pregnancy, and dietary protein intake is crucial for optimal maternal serum vitamin B-12 and ferritin status.
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH
(2022)
Article
Nutrition & Dietetics
Melda Kangalgil, Hulya Ulusoy, Sekine Turan, Kivanc Oncu
Summary: This study aimed to assess acute muscle loss, changes in anthropometric measurements, and the relationship between muscle loss and clinical outcomes in critically ill trauma and surgical patients. The results showed that muscle loss occurred rapidly during the first week of critical illness in these patients, and rectus femoris muscle cross-sectional area assessment can be used to detect skeletal muscle changes.
NUTRITION IN CLINICAL PRACTICE
(2022)
Article
Respiratory System
Ahmet Oguzhan Kucuk, Mehtap Pehlivanlar Kucuk, Aysegul Pehlivanlar, Sevil Ayaydin Murtezaoglu, Kadir Coban, Taha Semerci, Omer Topaloglu, Armagan Kaya, Ozlem Guler, Semanur Balcik Savaser, Busra Ozhan Akdemir, Olcay Aycicek, Funda Oztuna, Yilmaz Bulbul, Tevfik Ozlu
Summary: This study evaluated the characteristics and treatment outcomes of severe COVID-19 cases in a third-degree intensive care unit in Turkey. The study found that COVID-19 can progress rapidly to hospitalization and intensive care within a few days. The disease is severe and has a high mortality rate.
TUBERKULOZ VE TORAKS-TUBERCULOSIS AND THORAX
(2022)
Article
Critical Care Medicine
Nurel Erturk, Ahmet Oguzhan Kucuk, Merve Ozdogan Algin, Mehtap Pehlivantar Kucuk
Summary: Cardiac, pulmonary, and psychiatric complications can occur in COVID-19 patients receiving ECMO treatment due to long-term bed rest, infection, and critical illness neuropathy/myopathy. Physiotherapy and combined rehabilitation can help these patients recover faster and improve their quality of life after discharge.
TURKISH JOURNAL OF INTENSIVE CARE-TURK YOGUN BAKIM DERGISI
(2022)
Article
Emergency Medicine
Vildan Ozer, Ahmet Oguzhan Kucuk, Ahmet Eroglu, Kibar Yasar Guven, Huseyin Cetin Ketenci, Aynur Sahin, Ziad Kazzi
Summary: Calcium channel blocker poisonings are the most common agents causing mortality worldwide, and new approaches and updates on antidotal and supportive treatment are still being investigated. This case report discusses the life-saving effect of veno-arterial-extracorporeal membrane oxygenation support on patients exposed to cardiovascular system toxicity such as verapamil+trandolapril isosorbid dinitrate for suicidal purposes, who developed shock not responding to pharmacotherapy and antidote treatments at the 55th hour of drug intake.
EURASIAN JOURNAL OF EMERGENCY MEDICINE
(2022)
Article
Medicine, General & Internal
Olcay Aycicek, Ahmet Oguzhan Kucuk, Mehtap Pehlivanlar Kucuk, Merve Ozdogan Algin, Aysegul Pehlivanlar, Funda Oztuna
Summary: This study aimed to evaluate the relationship between blood transfusion frequency and disease prognosis in lung cancer patients receiving chemotherapy. Results showed that blood transfusion was associated with a higher rate of infection development and poorer disease progression. The study also found a significant difference in survival between patients who received blood transfusions and those who did not.
HASEKI TIP BULTENI-MEDICAL BULLETIN OF HASEKI
(2023)
Article
Medicine, General & Internal
Fethi Gul, Umut Sabri Kasapoglu, Mehmet Suleyman Sabaz, Pinar Ay, Burcin Doruk Oktay, Gulbahar Caliskan, Nalan Demir, Ismet Sayan, Feyyaz Kabadayi, Gulsum Altuntas, Ayca Gumus, Huelya Kirca, Deniz Sanli, Fatma Acil, Andac Dedeoglu, Sedef Gulcin Ural, Irem Akin Sen, Eda Macit Aydin, Hakan Dayanir, Birgul Yelken, Ilkay Ceylan, Osman Ozcan Aydin, Gunes Eskidemir, Ahmet Aytekin, Melike Cengiz, Ulku Arslan, Devrim Akdag, Gulcin Hilal Alay, Esra Tekin, Volkan Yarar, Kemal Tolga Saracoglu, Funda Gok, Volkan Alparslan, Verda Tuna, Murside Yildiz, Nimet Senoglu, Cenk Kirakli, Suleyman Yildirim, Kubra Sacar Kubuc, Aysen Erer, Hamza Gultekin, Kezban Ozmen Suner, Ozge Kuzgun, Cagatay Erman Ozturk, Aydin Karahan, Okan Deveci, Mustafa Ay, Dilara Tufek Oztan, Seda Banu Akinci, Melahat Yalcin Solak, Suha Bozbay, Serhat Ozciftci, Kamil Gonderen, Ahmet Oguzhan Kucuk, Berna Uyan, Gulseren Elay, Nazlihan Boyaci, Mustafa Timurkaan, Ebru Karakoc, Lerzan Dogan, Erdem Yalcinkaya, Leyla Kazancioglu, Gul Erdal Donmez, Baris Yilmaz, Dursun Firat Ergul, Maruf Boran, Hueseyin Ozkarakas, Bugra Karakas, Perihan Ergin Ozcan, Ilkay Anakli, Mustafa Kemal Bayar, Didem Yuksel, Sukriye Akdag, Ozcan Piskin, Sibel Temur, Selin Eyupoglu, Elvan Tekir Yilmaz, Gizem Zaim Avci, Raziye Turan, Fatma Alkan Bayburt, Helin Sahinturk, Bulent Gucyetmez, Mustafa Muhlis Alparslan, Metin Yarici, Fatma Yildirim, Abdulkadir Yektas, Guclu Yaman, Oktay Demirkiran, Ismail Cinel
Summary: This study aimed to investigate the impact of COVID-19 vaccines on the 28-day mortality in critically ill patients. The results showed that receiving at least two doses of CoronaVac significantly decreased mortality rates, indicating a clear benefit of vaccination in reducing deaths among critically ill patients with COVID-19.
BALKAN MEDICAL JOURNAL
(2023)
Article
Medicine, General & Internal
Gunes Comba Cebeci, Halil Cebeci, Mehtap Pehlivanlar Kucuk, Ahmet Oguzhan Kucuk, Ilkay Koray Bayrak, Fatma Ulger
Summary: The efficacy of neuromuscular electrical stimulation (NMES) in preventing muscle wasting in ICU patients with sepsis/septic shock was investigated. The group that received physiotherapy + NMES showed significantly lower loss in the upper extremities on days 14 and 21 compared to the group that received physiotherapy alone.
JCPSP-JOURNAL OF THE COLLEGE OF PHYSICIANS AND SURGEONS PAKISTAN
(2022)
Article
Medicine, General & Internal
Mehtap Pehlivanlar Kucuk, Ahmet Oguzhan Kucuk, Aysegul Pehlivanlar, Sevil Ayaydin Murtezaoglu, Kadir Coban, Gamze Kilic, Olcay Aycicek, Funda Oztuna, Yilmaz Bulbul, Tevfik Ozlu
Summary: This study investigated the efficacy of an IL-6 antagonist, Tocilizumab, administered in the early period for intensive care patients with COVID-19 pneumonia. The results showed that Tocilizumab reduced the overall mortality rate in intensive care patients with evidence of hypoxia and systemic inflammation.
TURKISH JOURNAL OF MEDICAL SCIENCES
(2022)
Article
Emergency Medicine
Ahmet Oguzhan Kucuk, Mehtap Pehlivanlar Kucuk, Olcay Aycicek, Goekalp Altun, Ahmet Coskun Ozdemir
Summary: This article presents the results of severe COVID-19 cases treated with ECMO support in our ICU for a period of three months. The study demonstrates the successful application of ECMO as a life-saving treatment option for severe acute respiratory distress syndrome in COVID-19 patients who do not respond to conventional treatments.
TURKISH JOURNAL OF EMERGENCY MEDICINE
(2022)