ATR phosphorylates DHX9 at serine 321 to suppress R-loop accumulation upon genotoxic stress

A DNA damage–induced phosphorylation circuit enhances Mec1 ATR Ddc2 ATRIP recruitment to Replication Protein A

(2023) Luke A. Yates et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Walking a tightrope: The complex balancing act of R-loops in genome stability

(2022) Joshua R. Brickner et al.   MOLECULAR CELL

DDX17 helicase promotes resolution of R-loop-mediated transcription–replication conflicts in human cells

(2022) Barbora Boleslavska et al.   NUCLEIC ACIDS RESEARCH

RNF168 regulates R-loop resolution and genomic stability in BRCA1/2-deficient tumors

(2021) Parasvi S. Patel et al.   JOURNAL OF CLINICAL INVESTIGATION

TDRD3 promotes DHX9 chromatin recruitment and R-loop resolution

(2021) Wei Yuan et al.   NUCLEIC ACIDS RESEARCH

SDE2 is an essential gene required for ribosome biogenesis and the regulation of alternative splicing

(2021) Jess Floro et al.   NUCLEIC ACIDS RESEARCH

DHX9-dependent recruitment of BRCA1 to RNA promotes DNA end resection in homologous recombination

(2021) Prasun Chakraborty et al.   Nature Communications

Replication protein A associates with nucleolar R loops and regulates rRNA transcription and nucleolar morphology

(2021) Shuang Feng et al.   GENES & DEVELOPMENT

Crosstalk between CST and RPA regulates RAD51 activity during replication stress

(2021) Kai-Hang Lei et al.   Nature Communications

Oxaliplatin-Induced DHX9 Phosphorylation Promotes Oncogenic Circular RNA CCDC66 Expression and Development of Chemoresistance

(2020) Ya-Chi Lin et al.   Cancers

High-resolution, strand-specific R-loop mapping via S9.6-based DNA–RNA immunoprecipitation and high-throughput sequencing

(2019) Lionel A. Sanz et al.   Nature Protocols

BRCA1-associated R-loop affects transcription and differentiation in breast luminal epithelial cells

(2019) Huai-Chin Chiang et al.   NUCLEIC ACIDS RESEARCH

R Loops: From Physiological to Pathological Roles

(2019) Tatiana García-Muse et al.   CELL

RNA/DNA Hybrid Interactome Identifies DXH9 as a Molecular Player in Transcriptional Termination and R-Loop-Associated DNA Damage

(2018) Agnese Cristini et al.   Cell Reports

BRCA2 Regulates Transcription Elongation by RNA Polymerase II to Prevent R-Loop Accumulation

(2018) Mahmud K.K. Shivji et al.   Cell Reports

SIRT7 and the DEAD-box helicase DDX21 cooperate to resolve genomic R loops and safeguard genome stability

(2017) Chenlin Song et al.   GENES & DEVELOPMENT

Functions of Replication Protein A as a Sensor of R Loops and a Regulator of RNaseH1

(2017) Hai Dang Nguyen et al.   MOLECULAR CELL

ATM, ATR, and DNA-PK: The Trinity at the Heart of the DNA Damage Response

(2017) Andrew N. Blackford et al.   MOLECULAR CELL

DHX9 suppresses RNA processing defects originating from the Alu invasion of the human genome

(2017) Tuğçe Aktaş et al.   NATURE

A subset of platinum-containing chemotherapeutic agents kills cells by inducing ribosome biogenesis stress

(2017) Peter M Bruno et al.   NATURE MEDICINE

A phosphorylation-and-ubiquitylation circuitry driving ATR activation and homologous recombination

(2017) Jean-Christophe Dubois et al.   NUCLEIC ACIDS RESEARCH

Proteomics Reveals Global Regulation of Protein SUMOylation by ATM and ATR Kinases during Replication Stress

(2017) Stephanie Munk et al.   Cell Reports

The biology of DHX9 and its potential as a therapeutic target

(2016) Teresa Lee et al.   Oncotarget

The Fanconi Anemia Pathway Maintains Genome Stability by Coordinating Replication and Transcription

(2015) Rebekka A. Schwab et al.   MOLECULAR CELL

BRCA1 Recruitment to Transcriptional Pause Sites Is Required for R-Loop-Driven DNA Damage Repair

(2015) Elodie Hatchi et al.   MOLECULAR CELL

R loops: new modulators of genome dynamics and function

(2015) José M. Santos-Pereira et al.   NATURE REVIEWS GENETICS

Breaking bad: R-loops and genome integrity

(2015) Julie Sollier et al.   TRENDS IN CELL BIOLOGY

The Fanconi Anemia Pathway Protects Genome Integrity from R-loops

(2015) María L. García-Rubio et al.   PLoS Genetics

RPA-coated single-stranded DNA as a platform for post-translational modifications in the DNA damage response

(2014) Alexandre Maréchal et al.   CELL RESEARCH

DNA-PK: A dynamic enzyme in a versatile DSB repair pathway

(2014) Anthony J. Davis et al.   DNA REPAIR

A double-edged sword: R loops as threats to genome integrity and powerful regulators of gene expression

(2014) K. Skourti-Stathaki et al.   GENES & DEVELOPMENT

Transcription-Coupled Nucleotide Excision Repair Factors Promote R-Loop-Induced Genome Instability

(2014) Julie Sollier et al.   MOLECULAR CELL

BRCA2 prevents R-loop accumulation and associates with TREX-2 mRNA export factor PCID2

(2014) Vaibhav Bhatia et al.   NATURE

RNaseH1 regulates TERRA-telomeric DNA hybrids and telomere maintenance in ALT tumour cells

(2014) Rajika Arora et al.   Nature Communications

Out of Balance: R-loops in Human Disease

(2014) Matthias Groh et al.   PLoS Genetics

Genome-Wide Profiling of Yeast DNA:RNA Hybrid Prone Sites with DRIP-Chip

(2014) Yujia A. Chan et al.   PLoS Genetics

PRP19 Transforms into a Sensor of RPA-ssDNA after DNA Damage and Drives ATR Activation via a Ubiquitin-Mediated Circuitry

(2013) Alexandre Maréchal et al.   MOLECULAR CELL

DHX9 helicase is involved in preventing genomic instability induced by alternatively structured DNA in human cells

(2013) A. Jain et al.   NUCLEIC ACIDS RESEARCH

Senataxin Associates with Replication Forks to Protect Fork Integrity across RNA-Polymerase-II-Transcribed Genes

(2012) Amaya Alzu et al.   CELL

R-loop-mediated genome instability in mRNA cleavage and polyadenylation mutants

(2012) P. C. Stirling et al.   GENES & DEVELOPMENT

R Loops: From Transcription Byproducts to Threats to Genome Stability

(2012) Andrés Aguilera et al.   MOLECULAR CELL

Human DHX9 helicase preferentially unwinds RNA-containing displacement loops (R-loops) and G-quadruplexes

(2011) Prasun Chakraborty et al.   DNA REPAIR

Yeast Sen1 Helicase Protects the Genome from Transcription-Associated Instability

(2011) Hannah E. Mischo et al.   MOLECULAR CELL

Human Senataxin Resolves RNA/DNA Hybrids Formed at Transcriptional Pause Sites to Promote Xrn2-Dependent Termination

(2011) Konstantina Skourti-Stathaki et al.   MOLECULAR CELL

Site-specific Phosphorylation Dynamics of the Nuclear Proteome during the DNA Damage Response

(2010) Martin V. Bennetzen et al.   MOLECULAR & CELLULAR PROTEOMICS

The DNA Damage Response: Making It Safe to Play with Knives

(2010) Alberto Ciccia et al.   MOLECULAR CELL

WRN helicase unwinds Okazaki fragment-like hybrids in a reaction stimulated by the human DHX9 helicase

(2010) Prasun Chakraborty et al.   NUCLEIC ACIDS RESEARCH

A Genome-wide siRNA Screen Reveals Diverse Cellular Processes and Pathways that Mediate Genome Stability

(2009) Renee D. Paulsen et al.   MOLECULAR CELL