Article
Multidisciplinary Sciences
Maoqing Jiang, Xiuyu Guo, Xiaohui Zhang, Qiaoling Gao, Weiqi Mei, Jingfeng Zhang, Jianjun Zheng
Summary: This study found a strong correlation between cigarette smoking and the metabolic activity of lung cancer on F-18-FDG PET/CT. Smokers had higher maximum standard uptake values (SUVmax) in the primary tumor, but no significant differences were observed in lymph nodes and distant metastasis. The pSUVmax increased significantly with cumulative smoking dose.
Article
Clinical Neurology
William Charles Kreisl, Patrick J. Lao, Aubrey Johnson, Zeljko Tomljanovic, Julia Klein, Krista Polly, Benjamin Maas, Krystal K. Laing, Anthony G. Chesebro, Kay Igwe, Qolamreza R. Razlighi, Lawrence S. Honig, Xinyu Yan, Seonjoo Lee, Akiva Mintz, Jose A. Luchsinger, Yaakov Stern, D. P. Devanand, Adam M. Brickman
Summary: F-18-MK-6240 showed good correlation with CSF tau and p-tau levels, as well as age, cognition, and amyloid-based AD biomarkers. The study also found that F-18-MK-6240 binding patterns were associated with specific cognitive impairments in amyloid-positive participants, reflecting the progression of AD pathology.
ALZHEIMERS & DEMENTIA
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ryuichi Harada, Pradith Lerdsirisuk, Yuki Shimizu, Yuka Yokoyama, Yiqing Du, Kaede Kudo, Michinori Ezura, Yoichi Ishikawa, Ren Iwata, Miho Shidahara, Aiko Ishiki, Akio Kikuchi, Yuya Hatano, Tomohiko Ishihara, Osamu Onodera, Yasushi Iwasaki, Mari Yoshida, Yasuyuki Taki, Hiroyuki Arai, Yukitsuka Kudo, Kazuhiko Yanai, Shozo Furumoto, Nobuyuki Okamura
Summary: Tau PET tracer [F-18]SNFT-1 has been developed with high selectivity and affinity for tau aggregates in Alzheimer's disease brains. The tracer showed promising results for tracking age-related accumulation of tau aggregates in the human brain, with higher signal-to-background ratio compared to other tau PET tracers.
JOURNAL OF NUCLEAR MEDICINE
(2023)
Article
Clinical Neurology
Danielle Mayblyum, J. Alex Becker, Heidi I. L. Jacobs, Rachel F. Buckley, Aaron P. Schultz, Jorge Sepulcre, Justin S. Sanchez, Zoe B. Rubinstein, Samantha R. Katz, Kirsten A. Moody, Patrizia Vannini, Kathryn Papp, Dorene M. Rentz, Julie C. Price, Reisa A. Sperling, Keith A. Johnson, Bernard J. Hanseeuw
Summary: This study compared different biomarkers and found that entorhinal hypometabolism is a strong and independent predictor of subsequent cognitive decline in preclinical Alzheimer's disease. Using high PiB and low entorhinal FDG as inclusion criteria significantly reduced the number of participants needed in a hypothetical trial.
Article
Clinical Neurology
Danielle V. Mayblyum, J. Alex Becker, Heidi I. L. Jacobs, Rachel F. Buckley, Aaron P. Schultz, Jorge Sepulcre, Justin S. Sanchez, Zoe B. Rubinstein, Samantha R. Katz, Kirsten A. Moody, Patrizia Vannini, Kathryn V. Papp, Dorene M. Rentz, Julie C. Price, Reisa A. Sperling, Keith A. Johnson, Bernard J. Hanseeuw
Summary: Comparing different biomarkers in participants with high and low levels of amyloid, this study found that entorhinal hypometabolism is a strong predictor of subsequent cognitive decline in preclinical Alzheimer's disease. Using a combination of high PiB and low entorhinal FDG as inclusion criteria in prevention trials significantly reduces the number of participants needed.
Article
Medicine, General & Internal
Cecile Tissot, Joseph Therriault, Peter Kunach, Andrea L. Benedet, Tharick A. Pascoal, Nicholas J. Ashton, Thomas K. Karikari, Stijn Servaes, Firoza Z. Lussier, Mira Chamoun, Dana L. Tudorascu, Jenna Stevenson, Nesrine Rahmouni, Nina Margherita Poltronetti, Vanessa Pallen, Gleb Bezgin, Min Su Kang, Sulantha S. Mathotaarachchi, Yi-Ting Wang, Jaime Fernandez Arias, Pamela Cristina Lukasewicz Ferreira, Joao Pedro Ferrari-Souza, Eugeen Vanmechelen, Kaj Blennow, Henrik Zetterberg, Serge Gauthier, Pedro Rosa-Neto
Summary: This study investigated the agreement between [F-18]MK6240 tau-PET, plasma pTau181, and pTau231 in Alzheimer's disease. The findings suggest that these biomarkers reflect different stages of tau progression and can be useful in diagnosing and evaluating the disease stage.
Article
Endocrinology & Metabolism
Karine Provost, Renaud La Joie, Amelia Strom, Leonardo Iaccarino, Lauren Edwards, Taylor J. Mellinger, Julie Pham, Suzanne L. Baker, Bruce L. Miller, William J. Jagust, Gil D. Rabinovici
Summary: The study found a high frequency of CCD in patients with neurodegenerative diseases and its association with neuropathology. Cortical asymmetry may contribute to cerebellar metabolic imbalance in some patients, increasing the likelihood of CCD occurrence.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2021)
Article
Neurosciences
Christina B. Young, Susan M. Landau, Theresa M. Harrison, Kathleen L. Poston, Elizabeth C. Mormino
Summary: The study investigates how reference region selection influences results related to disease stage, showing that different reference regions can lead to varying outcomes and impact the understanding of disease progression.
Article
Radiology, Nuclear Medicine & Medical Imaging
Alexandra Gogola, Davneet S. Minhas, Victor L. Villemagne, Ann D. Cohen, James M. Mountz, Tharick A. Pascoal, Charles M. Laymon, N. Scott Mason, Milos D. Ikonomovic, Chester A. Mathis, Beth E. Snitz, Oscar L. Lopez, William E. Klunk, Brian J. Lopresti
Summary: This study compared the characteristics of two frequently used tau PET tracers, F-18-flortaucipir and F-18-MK-6240, in the same subjects. The results showed that both tracers performed equally well in visual interpretations and were capable of quantifying signal in a common set of brain regions that develop tau pathology in Alzheimer disease. However, they also showed distinct patterns of apparent off-target binding, and F-18-MK-6240 exhibited a greater dynamic range in SUVR estimates.
JOURNAL OF NUCLEAR MEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Elizabeth C. Mormino, Tyler N. Toueg, Carmen Azevedo, Jessica B. Castillo, Wanjia Guo, Ayesha Nadiadwala, Nicole K. Corso, Jacob N. Hall, Audrey Fan, Alexandra N. Trelle, Marc B. Harrison, Madison P. Hunt, Sharon J. Sha, Gayle Deutsch, Michelle James, Carolyn A. Fredericks, Mary Ellen Koran, Michael Zeineh, Kathleen Poston, Michael D. Greicius, Mehdi Khalighi, Guido A. Davidzon, Bin Shen, Greg Zaharchuk, Anthony D. Wagner, Frederick T. Chin
Summary: In vivo measurements using (18)F-PI-2620 PET scans revealed significant differences in brain regions associated with Alzheimer's disease across different stages of the disease. This indicates the potential of (18)F-PI-2620 as a tool for visualizing tau aggregations in AD.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2021)
Article
Endocrinology & Metabolism
Suzanne L. Baker, Karine Provost, Wesley Thomas, A. J. Whitman, Mustafa Janabi, Mark E. Schmidt, Maarten Timmers, Hartmuth C. Kolb, Gil D. Rabinovici, William J. Jagust
Summary: The study evaluated the application of [F-18]-JNJ-067 in healthy older controls, mild cognitive impairment, Alzheimer's disease, and progressive supranuclear palsy patients, showing clear binding of the tracer in AD participants. However, the lack of binding in HCs, MCIs, and PSPs suggests that the tracer may not bind to low levels of AD-related tau or 4R tau.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Justin P. Wright, Jason R. Goodman, Yin-Guo Lin, Brian P. Lieberman, Jennifer Clemens, Luis F. Gomez, Qianwa Liang, Adam T. Hoye, Michael J. Pontecorvo, Kelly A. Conway
Summary: The study aimed to evaluate the binding of [F-18]flortaucipir to MAO-A and MAO-B and its potential impact on PET interpretation. Results showed specific binding of flortaucipir to tau NFT-rich Alzheimer's disease tissue but minimal binding to MAO-A and MAO-B.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Antoine Leuzy, Tharick A. Pascoal, Olof Strandberg, Philip Insel, Ruben Smith, Niklas Mattsson-Carlgren, Andrea L. Benedet, Hannah Cho, Chul H. Lyoo, Renaud La Joie, Gil D. Rabinovici, Rik Ossenkoppele, Pedro Rosa-Neto, Oskar Hansson
Summary: This study aimed to determine if comparable target regions of interest (ROIs) and cut-offs could be used across different tau PET tracers for the diagnosis of Alzheimer's disease dementia. Comparable diagnostic performance was observed between theory-driven and data-driven ROIs, with the temporal meta-ROI consistently performing well across all tracers with an SUVR threshold of approximately 1.35.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2021)
Article
Neurosciences
Huan-Chun Lin, Kun-Ju Lin, Kuo-Lun Huang, Shih-Hsin Chen, Tsung-Ying Ho, Chin-Chang Huang, Jung-Lung Hsu, Chiung-Chih Chang, Ing-Tsung Hsiao
Summary: This study proposed a method for visually interpreting tau-PET using the [F-18] Florzolotau tracer and investigated its performance and utility. The visual reading method generated a visual score with good sensitivity and specificity to identify AD-D or CU individuals from other patients.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Michael Rullmann, Matthias Brendel, Matthias L. Schroeter, Dorothee Saur, Johannes Levin, Robert G. Perneczky, Solveig Tiepolt, Marianne Patt, Andre Mueller, Victor L. Villemagne, Joseph Classen, Andrew W. Stephens, Osama Sabri, Henryk Barthel
Summary: This study utilized the F-18-PI-2620 tracer and PET imaging to perform Tau Braak staging in patients with AD, and found that PET positivity closely followed the Braak staging scheme, allowing for the categorization of most cases into the six-stage hierarchical Braak model.