Article
Pharmacology & Pharmacy
Haozhe Yu, Qicong Wang, Wenyu Wu, Weizhen Zeng, Yun Feng
Summary: Melatonin, a hormone critical in various physiological processes, has shown protective and therapeutic potentials for ocular diseases, with studies mainly focusing on glaucoma, myopia, and retinal diseases. Clinical trials have primarily targeted glaucoma, indicating a need for further research on various eye diseases and drug administration methods. Additionally, future research may explore melatonin sensors for personalized medication, its role in stem cell therapy, and the potential of food-derived melatonin for clinical applications.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Chemistry, Physical
Vittorio Bianco, Massimo D'Agostino, Daniele Pirone, Giusy Giugliano, Nicola Mosca, Maria Di Summa, Gianluca Scerra, Pasquale Memmolo, Lisa Miccio, Tommaso Russo, Ettore Stella, Pietro Ferraro
Summary: A generalized computational strategy based on self-consistent statistical inference is shown to achieve intracellular multi-specificity in single cells. Additionally, virtual reality is introduced for the first time to handle the information content of multi-specificity in single cells. This opens the way to a metaverse for 3D microscopy.
Article
Pharmacology & Pharmacy
Pinal Chaudhari, Vivek M. Ghate, Shaila A. Lewis
Summary: Contact lenses have diverse applications including bio-sensing, prevention of myopia, cosmetics, and drug delivery. Researchers have developed new approaches such as bioinspired polymeric systems and stimuli-responsive systems to overcome the disadvantages of medicated contact lenses. Recent innovations in ocular therapeutics have also gained significant attention.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2021)
Article
Pharmacology & Pharmacy
Anna Balasso, Astrid Subrizi, Stefano Salmaso, Francesca Mastrotto, Mariangela Garofalo, Miao Tang, Mei Chen, Heping Xu, Arto Urtti, Paolo Caliceti
Summary: The treatment of posterior segment disorders of the eye requires strategies to achieve prolonged drug effects. Innovative colloidal delivery systems can deliver drugs to the retina and prolong their intravitreal permanence. Bioconjugates are taken up by retinal RPE cells and show promise for long-acting intravitreal injectable drugs.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Review
Pharmacology & Pharmacy
Dmitriy Berillo, Zharylkasyn Zharkinbekov, Yevgeniy Kim, Kamila Raziyeva, Kamila Temirkhanova, Arman Saparov
Summary: Despite the conventional use of oral and intravenous routes for drug administration, they face limitations such as reduced bioavailability and invasiveness. Therefore, alternative delivery routes and modifications to drug formulations using stimuli-responsive polymers can improve drug release and bioavailability.
Review
Engineering, Biomedical
Dong Liu, Ting Wang, Yuan Lu
Summary: The article discusses the potential applications of untethered microrobots in medical treatment, particularly focusing on the advantages of active drug delivery systems compared to traditional passive systems. It introduces an integrated 5D radar chart analysis model and addresses the various factors that need to be considered before clinical application of microrobots.
ADVANCED HEALTHCARE MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Carolyn K. Jons, Abigail K. Grosskopf, Julie Baillet, Jerry Yan, John H. Klich, Olivia M. Saouaf, Eric A. Appel
Summary: This study evaluates the correlation between hydrogel rheology and depot formation and persistence following subcutaneous administration. The study finds that yield stress predicts initial depot formation, while creep predicts longer depot persistence for physically cross-linked hydrogels.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Multidisciplinary Sciences
Pedro P. G. Guimaraes, Christian G. Figueroa-Espada, Rachel S. Riley, Ningqiang Gong, Lulu Xue, Tomasz Sewastianik, Peter S. Dennis, Claudia Loebel, Amanda Chung, Sarah J. Shepherd, Rebecca M. Haley, Alex G. Hamilton, Rakan El-Mayta, Karin Wang, Robert Langer, Daniel G. Anderson, Ruben D. Carrasco, Michael J. Mitchell
Summary: Multiple myeloma (MM) is a hematologic malignancy that colonizes the bone marrow and lacks effective therapies. Endothelial cells in the bone marrow microenvironment, specifically Cyclophilin A (CyPA), play a critical role in MM progression and chemotherapeutic resistance. In this study, researchers developed a nanoparticle-based approach using RNA interference (RNAi) technology to target CyPA and inhibit MM cell extravasation. The strategy demonstrated promising results in vitro and in a murine xenograft model, indicating its potential as a therapeutic strategy for MM.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Review
Pharmacology & Pharmacy
Ta-Hsin Tsung, Yi-Hao Chen, Da-Wen Lu
Summary: The complex nature of the ocular drug delivery barrier poses challenges to effective drug administration. One promising approach is the use of biodegradable formulations, such as hydrogels, implants, and polymeric nanocarriers. Research in these areas is rapidly growing. This review provides an overview of recent updates in biodegradable formulations for ocular drug delivery, exploring their clinical use in different ocular diseases and highlighting their potential for future trends and practical clinical applications.
Review
Pharmacology & Pharmacy
Charis Rousou, Carl C. L. Schuurmans, Arto Urtti, Enrico Mastrobattista, Gert Storm, Chrit Moonen, Kai Kaarniranta, Roel Deckers
Summary: This review discusses the use of ultrasound and microbubbles for ocular drug delivery, focusing on enhancing efficacy by disrupting the blood-retina barrier, inducing cellular uptake, and achieving targeted delivery of genes. Safety and tolerability aspects of USMB are also highlighted as crucial for clinical translation.
Review
Polymer Science
Siphokazi B. K. Dludla, Leshasha T. Mashabela, Brian Ng'andwe, Pedzisai A. Makoni, Bwalya A. Witika
Summary: The application of nanotechnology in ophthalmic drug delivery systems shows great potential to overcome barriers faced by traditional ophthalmic formulations. Stimuli-responsive nano drug carriers have attracted significant attention due to their unique functionalities and therapeutic efficacy, playing a crucial role in the treatment and alleviation of ocular diseases.
Article
Biochemistry & Molecular Biology
Claudia Bonechi, Fariba Fahmideh Mahdizadeh, Luigi Talarico, Simone Pepi, Gabriella Tamasi, Gemma Leone, Marco Consumi, Alessandro Donati, Agnese Magnani
Summary: Glaucoma, a group of neurodegenerative diseases, is the second leading cause of irreversible blindness worldwide. The limited penetration of drugs through the ocular barrier reduces the systemic bioavailability, leading to the need for frequent drug administration and potential toxic effects. Liposomes and other novel drug-delivery systems can enhance the therapeutic efficacy of antiglaucomatous drugs by improving drug penetration, bioavailability, sustained release, tissue targeting, and reduction in intraocular pressure.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Faiza Benaouda, Ricardo Inacio, Chui Hua Lim, Haeeun Park, Thomas Pitcher, Mohamed A. Alhnan, Mazen M. S. Aly, Khuloud Al-Jamal, Ka-lung Chan, Rikhav P. Gala, Daniel Sebastia-Saez, Liang Cui, Tao Chen, Julie Keeble, Stuart A. Jones
Summary: This study demonstrates a novel method for needleless delivery of advanced therapies using a skin patch. By opening the skin appendages with a hypobaric chamber, direct delivery of vaccine antigens and drug nanoparticles was achieved. The patch was shown to enhance immune response to vaccine antigens and effectively reduce rat paw swelling.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Pharmacology & Pharmacy
Sofia M. Saraiva, Lucia Martin-Banderas, Matilde Duran-Lobato
Summary: The interest in using cannabinoids for medical applications, especially in treating eye conditions, has been growing. However, due to the unfavorable properties of cannabinoids and barriers for local administration in the eye, drug delivery systems are needed. This review focuses on identifying eye diseases that could be treated with cannabinoids, reviewing formulation properties, evaluating cannabinoid-based formulations for ocular administration, and exploring potential alternative formulations for eye administration.
Review
Chemistry, Multidisciplinary
Min Zhou, Yong-Jiang Li, Yu-Cheng Tang, Xin-Yan Hao, Wen-Jie Xu, Da-Xiong Xiang, Jun-Yong Wu
Summary: Extracellular vesicles (EVs), including apoptotic bodies (ABs), have emerged as promising candidates for various biomedical applications. ABs, derived from parent cells during the final stages of apoptosis, possess diverse sources and stable morphological features. They accommodate more functional biomolecules due to their larger volume and exhibit advantageous interactions with recipient cells through their predominant body surface ratio. ABs hold great potential in modulating and alleviating symptoms of numerous diseases, and have also been applied in disease diagnosis, immunotherapy, regenerative therapy, and drug delivery.
JOURNAL OF CONTROLLED RELEASE
(2022)