Article
Biochemistry & Molecular Biology
Ayushi Agrawal, Hasan Balci, Kristina Hanspers, Susan L. Coort, Marvin Martens, Denise N. Slenter, Friederike Ehrhart, Daniela Digles, Andra Waagmeester, Isabel Wassink, Tooba Abbassi-Daloii, Elisson N. Lopes, Aishwarya Iyer, Javier Millan Acosta, Lars G. Willighagen, Kozo Nishida, Anders Riutta, Helena Basaric, Chris T. Evelo, Egon L. Willighagen, Martina Kutmon, Alexander R. Pico
Summary: WikiPathways is an open-source biological pathway database that supports collaboration and open science, enabling content growth and collaboration among pathway researchers. In order to ensure the stability of community pathway curation in the future, WikiPathways has undergone major restructuring and website redesign to improve user experience.
NUCLEIC ACIDS RESEARCH
(2023)
Review
Toxicology
Anna Itkonen, Jukka Hakkola, Jaana Rysa
Summary: Pharmaceuticals and environmental contaminants contribute to hypercholesterolemia by activating pregnane X receptor (PXR). PXR activation disrupts lipid metabolism and promotes hypercholesterolemia through multiple mechanisms. This novel toxicity pathway is of great concern and requires further attention.
ARCHIVES OF TOXICOLOGY
(2023)
Article
Multidisciplinary Sciences
Holly M. Mortensen, Jonathan Senn, Trevor Levey, Phillip Langley, Antony J. Williams
Summary: The latest version of the EPA Adverse Outcome Pathway Database (AOP-DB v.2) introduces significant updates, including automated data pulls from AOP-Wiki 2.0, integration of tissue-gene network data, and human AOP-gene data by population. These updates allow users to investigate molecular targets of AOPs, relationships between different AOPs, cross-species or disease-AOP associations, and frequencies of functional variants related to AOPs in specific populations.
Review
Environmental Sciences
Allison A. Camp, David M. Lehmann
Summary: This article examines the impact of neonicotinoids on bumble bee populations and highlights the urgent need for additional studies, especially those focusing on cellular and organ responses in bumble bees exposed to neonicotinoids. Through the AOP framework, existing literature on the adverse outcome pathways is summarized, emphasizing the importance of addressing data gaps in the bumble bee research community.
ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY
(2021)
Article
Cell Biology
Maria Jose Sisalli, Salvatore Della Notte, Agnese Secondo, Carmelo Ventra, Lucio Annunziato, Antonella Scorziello
Summary: The study investigated whether pharmacological strategies improving mitochondrial functions could prevent neuronal dysfunction in Parkinson's disease. Using the amino acid ornithine, the compound LOLA was found to improve mitochondrial functions and reduce cytosolic calcium levels by modulating nitric oxide production. These results reveal the close relationship between cytosolic ionic homeostasis and cellular metabolism.
Review
Biology
Wei Qin, Yirong Shi, Weimei Chen, Xiaokang Jia, Tetsuya Asakawa
Summary: This review summarizes the association of the tryptophan-kynurenine pathway (KP) with Parkinson's disease (PD) and discusses the clinical value of KP as a potential novel target for PD treatment.
Review
Biochemistry & Molecular Biology
Patrudu Makena, Tatiana Kikalova, Gaddamanugu L. L. Prasad, Sarah A. A. Baxter
Summary: Lung fibrosis is a progressive fatal disease caused by deregulated wound healing of lung epithelial cells. Chronic cigarette smoking and oxidative stress are major risk factors for lung fibrosis. This study aims to develop an adverse outcome pathway (AOP) to investigate the mechanisms of lung fibrosis due to lung injury caused by inhaled toxicants, including cigarette smoke. Cellular and tissue-level events lead to the development of lung fibrosis through proinflammatory and profibrotic mediators.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cell Biology
Yiju Wei, Wei Li
Summary: The Hippo pathway is a critical signaling network that regulates organ development and tissue homeostasis. Recent studies have identified calcium as a potential messenger in transducing signals to the main signaling machinery.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Igor Mindukshev, Ekaterina Fock, Irina Dobrylko, Julia Sudnitsyna, Stepan Gambaryan, Mikhail A. Panteleev
Summary: Hypo- and hyperthermia have different effects on platelet activation and intracellular calcium concentration, leading to changes in platelet shape, aggregation, and clot formation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Pharmacology & Pharmacy
Mathieu Vinken
Summary: Up to half of hospitalized COVID-19 patients may experience liver damage, which can be caused either by direct actions of the virus or pharmacological treatment. Research suggests that liver injury may result from direct viral binding and local actions in cholangiocytes, or indirectly from systemic hypoxia and inflammation in patients. URGENT further research is needed to fill knowledge gaps for future targeted development of vaccines and therapies.
Review
Nanoscience & Nanotechnology
Zekun Liu, Tianxue Zhu, Junru Wang, Zijian Zheng, Yi Li, Jiashen Li, Yuekun Lai
Summary: This paper reviews the latest advances in fiber-based wearable strain sensors, including the methods for preparing conductive fibers, the fabrication and sensing mechanisms of state-of-the-art sensors, and their applications in various fields. It also critically analyzes the challenges and future prospects of fiber-based strain sensors.
NANO-MICRO LETTERS
(2022)
Review
Materials Science, Biomaterials
Khushboo Warjurkar, Satyajit Panda, Vinay Sharma
Summary: The accidental discovery of carbon dots in 2004 has led to their widespread use in the biomedical field. Red emissive carbon dots (RCDs) have been developed to overcome the limitations of blue-green emitting CDs, showing deep tissue penetration, minimal photodamage, low auto-fluorescence, and high imaging contrast. This article presents a thorough review on the use of RCDs in biomedical applications, including in vivo and in vitro bioimaging, photoacoustic imaging, monitoring temperature and polarity changes in living cells, tumour therapy, and drug delivery.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Article
Nanoscience & Nanotechnology
Huizhu Tan, Kuirong Mao, Xiuxiu Cong, Yanbao Xin, Feiqi Liu, Jialiang Wang, Xin Wang, Jing Han, Yuning Zhang, Yong-Guang Yang, Tianmeng Sun
Summary: Calcium is essential for the human body, playing a crucial role in intracellular signaling. Recent studies have shown that changes in intracellular calcium concentration can affect immune cell function. This study developed calcium carbonate nanoparticles to modulate calcium concentration and found that they could alter immune cell populations and activate specific immune cells. These nanoparticles also exhibited adjuvant properties without the need for antigenic stimulation. Overall, this research highlights the importance of modulating calcium concentration to regulate immune cell function.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Multidisciplinary Sciences
Ewa Sieliwonczyk, Bert Vandendriessche, Charlotte Claes, Evy Mayeur, Maaike Alaerts, Philip Holmgren, Tycho Canter Cremers, Dirk Snyders, Bart Loeys, Dorien Schepers
Summary: Despite challenges, researchers have developed a novel method to improve knock-in efficiency using CRISPR-Cas9 technique in zebrafish. By combining the early selection procedure with genotyping and next-generation sequencing, they achieved a significant increase in somatic editing efficiency and demonstrated potential for improving germline transmission in pre-selected embryos.
SCIENTIFIC REPORTS
(2023)
Article
Environmental Sciences
Yuan Jin, Meiyao Feng, Wanli Ma, Yanhong Wei, Guangshuai Qi, Jiao Luo, Lin Xu, Xinmei Li, Chuanhai Li, Ying Wang, Daochuan Li, Jing Chen, Yanjie Zhao, Yufei Hou, Qianwen Zhao, Lidan Jiang, Mengyue Xie, Yuxin Zheng, Dianke Yu
Summary: Developing the adverse outcome pathway (AOP) framework is a promising approach to identify potential hazards of new chemicals to the environment and human health. Utilizing data from comparative toxicogenomics database (CTD) and Ingenuity Pathway Analysis (IPA) helps in developing reliable and sensible AOPs. This method speeds up AOP development by collecting fragmented bioinformation in published studies efficiently.
ENVIRONMENTAL POLLUTION
(2021)