Advancing social behavioral neuroscience by integrating ethology and comparative psychology methods through machine learning

A paradigm shift in translational psychiatry through rodent neuroethology

(2023) Yair Shemesh et al.   MOLECULAR PSYCHIATRY

Ecological validity of social defeat stressors in mouse models of vulnerability and resilience

(2023) David M. Lyons et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Fear circuit–based neurobehavioral signatures mirror resilience to chronic social stress in mouse

(2023) Sarah Ayash et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neural systems that facilitate the representation of social rank

(2022) Madeleine F. Dwortz et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Superior Colliculus to VTA pathway controls orienting response and influences social interaction in mice

(2022) Clément Solié et al.   Nature Communications

Toward the explainability, transparency, and universality of machine learning for behavioral classification in neuroscience

(2022) Nastacia L. Goodwin et al.   CURRENT OPINION IN NEUROBIOLOGY

Cortical ensembles orchestrate social competition through hypothalamic outputs

(2022) Nancy Padilla-Coreano et al.   NATURE

SLEAP: A deep learning system for multi-animal pose tracking

(2022) Talmo D. Pereira et al.   NATURE METHODS

Multi-animal pose estimation, identification and tracking with DeepLabCut

(2022) Jessy Lauer et al.   NATURE METHODS

Pushing the frontiers: tools for monitoring neurotransmitters and neuromodulators

(2022) Zhaofa Wu et al.   NATURE REVIEWS NEUROSCIENCE

Midbrain projection to the basolateral amygdala encodes anxiety-like but not depression-like behaviors

(2022) Carole Morel et al.   Nature Communications

Oxytocin neurons mediate the effect of social isolation via the VTA circuits

(2022) Stefano Musardo et al.   eLife

Characterizing the behavioral and neuroendocrine features of susceptibility and resilience to social stress

(2022) Dalia Murra et al.   Neurobiology of Stress

Ketamine exerts its sustained antidepressant effects via cell-type-specific regulation of Kcnq2

(2022) Juan Pablo Lopez et al.   NEURON

Reciprocal cortico-amygdala connections regulate prosocial and selfish choices in mice

(2022) Diego Scheggia et al.   NATURE NEUROSCIENCE

Experimenters’ sex modulates mouse behaviors and neural responses to ketamine via corticotropin releasing factor

(2022) Polymnia Georgiou et al.   NATURE NEUROSCIENCE

Beyond the three-chamber test: toward a multimodal and objective assessment of social behavior in rodents

(2022) Renad Jabarin et al.   Molecular Autism

Distinct forms of regret linked to resilience versus susceptibility to stress are regulated by region-specific CREB function in mice

(2022) Romain Durand-de Cuttoli et al.   Science Advances

Identifying behavioral structure from deep variational embeddings of animal motion

(2022) Kevin Luxem et al.   Communications Biology

Neural circuits of social behaviors: innate yet flexible

(2021) Dongyu Wei et al.   NEURON

Male–Female Differences in the Effects of Age on Performance Measures Recorded for 23 Hours in Mice

(2021) Trang Tran et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

B-SOiD, an open-source unsupervised algorithm for identification and fast prediction of behaviors

(2021) Alexander I. Hsu et al.   Nature Communications

VTA dopamine neuron activity encodes social interaction and promotes reinforcement learning through social prediction error

(2021) Clément Solié et al.   NATURE NEUROSCIENCE

The Mouse Action Recognition System (MARS) software pipeline for automated analysis of social behaviors in mice

(2021) Cristina Segalin et al.   eLife

Individual history of winning and hierarchy landscape influence stress susceptibility in mice

(2021) Katherine B LeClair et al.   eLife

Ethanol intake in male mice exposed to social defeat: Environmental enrichment potentiates resilience

(2021) Marina D. Reguilón et al.   Neurobiology of Stress

Reversal of synaptic and behavioral deficits in a 16p11.2 duplication mouse model via restoration of the GABA synapse regulator Npas4

(2020) Benjamin Rein et al.   MOLECULAR PSYCHIATRY

A complete pupillometry toolbox for real-time monitoring of locus coeruleus activity in rodents

(2020) Mattia Privitera et al.   Nature Protocols

Reproducibility of animal research in light of biological variation

(2020) Bernhard Voelkl et al.   NATURE REVIEWS NEUROSCIENCE

Deep learning-based behavioral analysis reaches human accuracy and is capable of outperforming commercial solutions

(2020) Oliver Sturman et al.   NEUROPSYCHOPHARMACOLOGY

Big behavior: challenges and opportunities in a new era of deep behavior profiling

(2020) Lukas von Ziegler et al.   NEUROPSYCHOPHARMACOLOGY

Rage Against the Machine: Advancing the study of aggression ethology via machine learning.

(2020) Nastacia L. Goodwin et al.   PSYCHOPHARMACOLOGY

Computational Analysis of Multidimensional Behavioral Alterations After Chronic Social Defeat Stress

(2020) Zachary S. Lorsch et al.   BIOLOGICAL PSYCHIATRY

Revealing the structure of pharmacobehavioral space through motion sequencing

(2020) Alexander B. Wiltschko et al.   NATURE NEUROSCIENCE

A standardized social preference protocol for measuring social deficits in mouse models of autism

(2020) Benjamin Rein et al.   Nature Protocols

Social dominance mediates behavioral adaptation to chronic stress in a sex-specific manner

(2020) Stoyo Karamihalev et al.   eLife

The reverse translation of a quantitative neuropsychiatric framework into preclinical studies: Focus on social interaction and behavior

(2019) Tatiana Peleh et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Using the tube test to measure social hierarchy in mice

(2019) Zhengxiao Fan et al.   Nature Protocols

Real-time analysis of the behaviour of groups of mice via a depth-sensing camera and machine learning

(2019) Fabrice de Chaumont et al.   Nature Biomedical Engineering

RFID-supported video tracking for automated analysis of social behaviour in groups of mice

(2019) Tatiana Peleh et al.   JOURNAL OF NEUROSCIENCE METHODS

Behavioral, circuitry, and molecular aberrations by region-specific deficiency of the high-risk autism gene Cul3

(2019) Maximiliano Rapanelli et al.   MOLECULAR PSYCHIATRY

DeepPoseKit, a software toolkit for fast and robust animal pose estimation using deep learning

(2019) Jacob M Graving et al.   eLife

Identity domains capture individual differences from across the behavioral repertoire

(2019) Oren Forkosh et al.   NATURE NEUROSCIENCE

Neural Basis of Observational Fear Learning: A Potential Model of Affective Empathy

(2019) Sehoon Keum et al.   NEURON

Deep learning tools for the measurement of animal behavior in neuroscience

(2019) Mackenzie Weygandt Mathis et al.   CURRENT OPINION IN NEUROBIOLOGY

Effects of Early-Life Stress on Social and Anxiety-Like Behaviors in Adult Mice: Sex-Specific Effects

(2018) Natalya P. Bondar et al.   BEHAVIOURAL NEUROLOGY

Advances in understanding neural mechanisms of social dominance

(2018) Tingting Zhou et al.   CURRENT OPINION IN NEUROBIOLOGY

Social deficits in Shank3-deficient mouse models of autism are rescued by histone deacetylase (HDAC) inhibition

(2018) Luye Qin et al.   NATURE NEUROSCIENCE

Neural Circuit Mechanisms of Social Behavior

(2018) Patrick Chen et al.   NEURON

DeepLabCut: markerless pose estimation of user-defined body parts with deep learning

(2018) Alexander Mathis et al.   NATURE NEUROSCIENCE

Role of VTA dopamine neurons and neuroligin 3 in sociability traits related to nonfamiliar conspecific interaction

(2018) Sebastiano Bariselli et al.   Nature Communications

Ethanol facilitates socially evoked memory recall in mice by recruiting pain-sensitive anterior cingulate cortical neurons

(2018) Tetsuya Sakaguchi et al.   Nature Communications

Social interactions impact on the dopaminergic system and drive individuality

(2018) N. Torquet et al.   Nature Communications

Stress-induced changes in social dominance are scaled by AMPA-type glutamate receptor phosphorylation in the medial prefrontal cortex

(2018) Min-Jung Park et al.   Scientific Reports

Fast animal pose estimation using deep neural networks

(2018) Talmo D. Pereira et al.   NATURE METHODS

Extinction of Fear Memory Attenuates Conditioned Cardiovascular Fear Reactivity

(2018) Adam P. Swiercz et al.   Frontiers in Behavioral Neuroscience

Pharmacological Modulation of the Psychiatric Risk Factor FKBP51 Alters Efficiency of Common Antidepressant Drugs

(2018) Max L. Pöhlmann et al.   Frontiers in Behavioral Neuroscience

Mice lacking a functional NMDA receptor exhibit social subordination in a group-housed environment

(2017) Waka Ujita et al.   FEBS Journal

Aggression in group-housed laboratory mice: why can't we solve the problem?

(2017) Elin M. Weber et al.   LAB ANIMAL

Systematic heterogenization for better reproducibility in animal experimentation

(2017) S Helene Richter   LAB ANIMAL

An Integrative Interdisciplinary Perspective on Social Dominance Hierarchies

(2017) Chen Qu et al.   TRENDS IN COGNITIVE SCIENCES

Oxytocin enhances observational fear in mice

(2017) Marc T. Pisansky et al.   Nature Communications

Dorsal Raphe Dopamine Neurons Represent the Experience of Social Isolation

(2016) Gillian A. Matthews et al.   CELL

Feeding Experimentation Device (FED): A flexible open-source device for measuring feeding behavior

(2016) Katrina P. Nguyen et al.   JOURNAL OF NEUROSCIENCE METHODS

CLK2 inhibition ameliorates autistic features associated with SHANK3 deficiency

(2016) Michael Bidinosti et al.   SCIENCE

Age-related changes in behavior in C57BL/6J mice from young adulthood to middle age

(2016) Hirotaka Shoji et al.   Molecular Brain

Social impairment in schizophrenia

(2015) David Dodell-Feder et al.   CURRENT OPINION IN PSYCHIATRY

Effects of Striatal ΔFosB Overexpression and Ketamine on Social Defeat Stress–Induced Anhedonia in Mice

(2014) Rachel J. Donahue et al.   BIOLOGICAL PSYCHIATRY

Olfactory exposure to males, including men, causes stress and related analgesia in rodents

(2014) Robert E Sorge et al.   NATURE METHODS

Early deprivation induces competitive subordinance in C57BL/6 male mice

(2014) Seico Benner et al.   PHYSIOLOGY & BEHAVIOR

The mouse that roared: neural mechanisms of social hierarchy

(2014) Fei Wang et al.   TRENDS IN NEUROSCIENCES

Animal models of social avoidance and social fear

(2013) Iulia Toth et al.   CELL AND TISSUE RESEARCH

High-order social interactions in groups of mice

(2013) Yair Shemesh et al.   eLife

Testing declarative memory in laboratory rats and mice using the nonconditioned social discrimination procedure

(2011) Mario Engelmann et al.   Nature Protocols

A standardized protocol for repeated social defeat stress in mice

(2011) Sam A Golden et al.   Nature Protocols

The Neuropeptide Oxytocin Facilitates Pro-Social Behavior and Prevents Social Avoidance in Rats and Mice

(2011) Michael Lukas et al.   NEUROPSYCHOPHARMACOLOGY

Bidirectional Control of Social Hierarchy by Synaptic Efficacy in Medial Prefrontal Cortex

(2011) F. Wang et al.   SCIENCE

C57BL/6J mice fail to exhibit preference for social novelty in the three-chamber apparatus

(2010) Brandon L. Pearson et al.   BEHAVIOURAL BRAIN RESEARCH

Darwin as a student of behavior

(2010) Bernard Thierry   COMPTES RENDUS BIOLOGIES

Towards an integrative understanding of social behavior: new models and new opportunities

(2010) Daniel T. Blumstein   Frontiers in Behavioral Neuroscience

Environmental standardization: cure or cause of poor reproducibility in animal experiments?

(2009) S Helene Richter et al.   NATURE METHODS

Behavioural battery testing: Evaluation and behavioural outcomes in 8 inbred mouse strains

(2009) Heena Vanmalibhai Lad et al.   PHYSIOLOGY & BEHAVIOR