Review
Biochemistry & Molecular Biology
Thom M. Molenaar, Fred van Leeuwen
Summary: Histone modifying enzymes have important roles in cellular processes and disease. SETD2, for example, methylates histone H3 on lysine 36 (H3K36) during transcription and also methylates non-histone substrates. Understanding the multiple roles of SETD2 is crucial for understanding its role in disease, particularly in cancer where it is frequently inactivated.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Review
Medicine, Research & Experimental
Janice Jacson Mandumpala, Stephin Baby, Antriya Annie Tom, Chandraiah Godugu, Nagula Shankaraiah
Summary: Triple-negative breast cancer (TNBC) is a highly lethal subtype of breast cancer with limited treatment options due to its complexity, drug resistance, and lack of therapeutic targets. Recent studies have shown the importance of epigenetic regulation in TNBC development, with a focus on histone methyltransferases and histone demethylases as potential targets for new targeted therapies in TNBC treatment.
Review
Cell Biology
Aidan J. Levinsky, Gregor McEdwards, Nasha Sethna, Mark A. Currie
Summary: H3K9 methyltransferases play crucial roles in genome stability, cell type-specific gene expression, and non-histone methylation. They are involved in histone modification and regulate the methylation of various non-histone targets, contributing to genome regulation and cellular functions.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Joanna Szczepanek, Monika Skorupa, Joanna Jarkiewicz-Tretyn, Cezary Cybulski, Andrzej Tretyn
Summary: Breast cancer demonstrates diverse epigenetic abnormalities that impact gene expression and tumor characteristics. Epigenetic alterations are crucial in cancer development and progression, and drugs targeting epigenetic modifications show promise for cancer treatment, including DNA methyltransferase inhibitors, histone-modifying enzymes, and mRNA regulators. However, currently, there is no effective standalone epigenetic drug therapy for breast cancer. Combining epigenetic drugs with conventional therapies has shown positive results, and targeting specific epigenetic changes may lead to more effective monotherapy options in the future.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Melanie A. Whitmore, Hong Li, Wentao Lyu, Sharmily Khanam, Guolong Zhang
Summary: The combination of HDACi and DNMTi/HMTi showed a strong synergy in inducing HDP gene expression, and also regulated the expression of tight junction proteins.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Margarita E. Neganova, Sergey G. Klochkov, Yulia R. Aleksandrova, Gjumrakch Aliev
Summary: Epigenetic changes associated with histone modifications are important in the emergence and maintenance of various cancer types. Inhibitors of enzymes involved in these modifications are promising for anticancer drug development. This review explores the main features of common histone modifications and their role in malignant neoplasms, discussing strategies for inhibitor development and analyzing the use of multitarget drugs as the most promising strategy.
SEMINARS IN CANCER BIOLOGY
(2022)
Review
Urology & Nephrology
Anbarasu Kumaraswamy, Katherine R. Welker Leng, Thomas C. Westbrook, Joel A. Yates, Shuang G. Zhao, Christopher P. Evans, Felix Y. Feng, Todd M. Morgan, Joshi J. Alumkal
Summary: This study systematically reviewed the role of epigenetic factors in prostate cancer from 2015 to 2020, highlighting key preclinical and translational data. Findings from both preclinical and clinical studies were reviewed and summarized, along with a discussion on 12 ongoing clinical studies with epigenetic targeted therapies.
Review
Biochemistry & Molecular Biology
Lidia Borkiewicz
Summary: Cancer development and progression are governed by complex genetic and epigenetic changes, with histone 3 trimethylation of lysine 27 (H3K27me3) playing a significant role in silencing tumor suppressor genes in breast cancer. This review highlights the importance of H3K27me3 status in breast cancer biology and potential therapeutic implications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Haining Zhou, Chad B. Stein, Tiasha A. Shafiq, Gergana Shipkovenska, Marian Kalocsay, Joao A. Paulo, Jiuchun Zhang, Zhenhua Luo, Steven P. Gygi, Karen Adelman, Danesh Moazed
Summary: Polycomb repressive complexes (PRCs) and the RIX1 complex work together to silence Polycomb target genes in human cells, with the recruitment of the RIX1 complex to chromatin being essential for silencing.
Article
Multidisciplinary Sciences
Wendan Ren, Huitao Fan, Sara A. Grimm, Jae Jin Kim, Linhui Li, Yiran Guo, Christopher James Petell, Xiao-Feng Tan, Zhi-Min Zhang, John P. Coan, Jiekai Yin, Dae In Kim, Linfeng Gao, Ling Cai, Nelli Khudaverdyan, Burak Cetin, Dinshaw J. Patel, Yinsheng Wang, Qiang Cui, Brian D. Strahl, Or Gozani, Kyle M. Miller, Sean E. O'Leary, Paul A. Wade, Gang Greg Wang, Jikui Song
Summary: The study reveals that DNA methyltransferase DNMT1 acts as a reader for histone H4K20 trimethylation through its BAH1 domain, ensuring optimal maintenance of DNA methylation at repetitive LINE-1 elements.
NATURE COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Lucie Malbeteau, Julien Jacquemetton, Cecile Languilaire, Laura Corbo, Muriel Le Romancer, Coralie Poulard
Summary: The progesterone receptor (PR) plays a crucial role in women's physiological and pathological responses, especially in breast cancer development. It has been found that the hormone-free form of PR is involved in maintaining the stability of breast cancer cells under hormone-depleted conditions. In this study, the researchers identified PRMT1 as a novel player in the signaling of unliganded PR.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Oncology
Richard Sean Lee, Kirti Sad, Dorelle V. Fawwal, Jennifer Marie Spangle
Summary: Breast cancer is a frequent and deadly disease in women, with histone-modifying enzymes playing a role in treatment response and patient outcomes. Epigenetic changes to chromatin affect the tumor environment and can be targeted for breast cancer treatment. Understanding these mechanisms may improve therapeutic interventions and patient outcomes.
Review
Gastroenterology & Hepatology
Eid Alshammari, Ying-Xue Zhang, Zhe Yang
Summary: This article reviews the role of SMYD2 in initiating and sustaining PDAC development through methylation of multiple tumor suppressors and oncogenic proteins. The mechanistic extrapolation of SMYD2 from other cancers may provide insights into the mechanisms driving PDAC tumor growth and metastasis, suggesting that targeting SMYD2 could be a powerful strategy for preventing and treating PDAC.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Biology
Abigail R. R. Guillermo, Karolina Chocian, Gavriil Gavriilidis, Julien Vandamme, Anna Elisabetta Salcini, Jane Mellor, Alison Woollard
Summary: This study identifies chromatin modifiers as key regulators of longevity, with interactions between different factors such as expression levels and tissue specificity influencing lifespan outcomes. When considering molecular and tissue-specific effects, the heterochromatin loss model of ageing may be too simplistic to fully explain organismal ageing.
Article
Biology
Bhagyshree Jamge, Zdravko J. Lorkovic, Elin Axelsson, Akihisa Osakabe, Vikas Shukla, Ramesh Yelagandula, Svetlana Akimcheva, Annika Luisa Kuehn, Frederic Berger
Summary: This study investigates the assembly of histone variants and histone modifications in Arabidopsis thaliana genome and finds that both histone variants and modifications play significant roles in determining chromatin states. Particularly, there are strong associations between H2A variants and specific combinations of histone modifications. The loss of the chromatin remodeler DDM1 affects the exchange of histone variant H2A.Z, resulting in significant effects on the definition and distribution of chromatin states.
Article
Biochemical Research Methods
Ivo J. Huijbers, Jessica Del Bravo, Rahmen Bin Ali, Colin Pritchard, Tanya M. Braumuller, Martine H. van Miltenburg, Linda Henneman, Ewa M. Michalak, Anton Berns, Jos Jonkers
Article
Multidisciplinary Sciences
Linda Henneman, Martine H. van Miltenburg, Ewa M. Michalak, Tanya M. Braumuller, Janneke E. Jaspers, Anne Paulien Drenth, Renske de Korte-Grimmerink, Ewa Gogola, Karoly Szuhai, Andreas Schlicker, Rahmen Bin Ali, Colin Pritchard, Ivo J. Huijbers, Anton Berns, Sven Rottenberg, Jos Jonkers
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2015)
Article
Hematology
Lina Happo, Mark S. Cragg, Belinda Phipson, Jon M. Haga, Elisa S. Jansen, Marco J. Herold, Grant Dewson, Ewa M. Michalak, Cassandra J. Vandenberg, Gordon K. Smyth, Andreas Strasser, Suzanne Cory, Clare L. Scott
Article
Hematology
Ophelie Meynet, Barbara Zunino, Lina Happo, Ludivine A. Pradelli, Johanna Chiche, Marie A. Jacquin, Laura Mondragon, Jean-Francois Tanti, Bruno Taillan, Georges Garnier, Julie Reverso-Meinietti, Nicolas Mounier, Jean-Francois Michiels, Ewa M. Michalak, Michel Carles, Clare L. Scott, Jean-Ehrland Ricci
Article
Medicine, Research & Experimental
Ivo J. Huijbers, Rahmen Bin Ali, Colin Pritchard, Miranda Cozijnsen, Min-Chul Kwon, Natalie Proost, Ji-Ying Song, Hilda de Vries, Jitendra Badhai, Kate Sutherland, Paul Krimpenfort, Ewa M. Michalak, Jos Jonkers, Anton Berns
EMBO MOLECULAR MEDICINE
(2014)
Article
Cell Biology
Ewa M. Michalak, Cassandra J. Vandenberg, Alex R. D. Delbridge, Li Wu, Clare L. Scott, Jerry M. Adams, Andreas Strasser
GENES & DEVELOPMENT
(2010)
Article
Biochemistry & Molecular Biology
Lindsay C. Spender, Matthew J. Carter, Darren I. O'Brien, Louise J. Clark, Jian Yu, Ewa M. Michalak, Lina Happo, Mark S. Cragg, Gareth J. Inman
JOURNAL OF BIOLOGICAL CHEMISTRY
(2013)
Article
Oncology
Ewa Malgorzata Michalak, Jos Jonkers
JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA
(2011)
Article
Oncology
Karin E. de Visser, Metamia Ciampricotti, Ewa M. Michalak, David Wei-Min Tan, Ewoud N. Speksnijder, Cheei-Sing Hau, Hans Clevers, Nick Barker, Jos Jonkers
JOURNAL OF PATHOLOGY
(2012)
Article
Biochemistry & Molecular Biology
Jeffrey B. Kerr, Karla J. Hutt, Ewa M. Michalak, Michele Cook, Cassandra J. Vandenberg, Seng H. Liew, Philippe Bouillet, Alea Mills, Clare L. Scott, Jock K. Findlay, Andreas Strasser
Article
Cell & Tissue Engineering
Ewa Malgorzata Michalak, Karim Nacerddine, Alexandra Pietersen, Vincent Beuger, Inka Pawlitzky, Paulien Cornelissen-Steijger, Ellen Wientjens, Ellen Tanger, Jost Seibler, Maarten van Lohuizen, Jos Jonkers
Article
Cell Biology
Liz J. Valente, Daniel H. D. Gray, Ewa M. Michalak, Josefina Pinon-Hofbauer, Alex Egle, Clare L. Scott, Ana Janic, Andreas Strasser
Article
Biochemistry & Molecular Biology
Ewa M. Michalak, Michael J. G. Milevskiy, Rachel M. Joyce, Johanna F. Dekkers, Paul R. Jamieson, Bhupinder Pal, Caleb A. Dawson, Yifang Hu, Stuart H. Orkin, Warren S. Alexander, Geoffrey J. Lindeman, Gordon K. Smyth, Jane E. Visvader
Review
Cell Biology
Ewa M. Michalak, Marian L. Burr, Andrew J. Bannister, Mark A. Dawson
NATURE REVIEWS MOLECULAR CELL BIOLOGY
(2019)
Article
Oncology
Andra S. Martinikova, Miroslav Stoyanov, Anna Oravetzova, Yannick P. Kok, Shibo Yu, Jana Dobrovolna, Pavel Janscak, Marcel van Vugt, Libor Macurek
Summary: Oncogene-induced replication stress is a major cause of genome instability in cancer cells. This study reveals that increased activity of PPM1D exacerbates replication stress caused by cyclin E1 overexpression, leading to abnormal cell cycle progression and accumulation of DNA copy number alterations. Pharmacological inhibition of PPM1D can alleviate replication stress-induced genome instability.
MOLECULAR ONCOLOGY
(2024)
Article
Oncology
Alamelu G. Bharadwaj, Meghan E. McLean, Margaret L. Dahn, Hannah F. Cahill, Marie-Claire D. Wasson, Raj Pranap Arun, Olivia L. Walker, Brianne M. Cruickshank, Wasundara Fernando, Jaganathan Venkatesh, Penelope J. Barnes, Gillian Bethune, Gregory Knapp, Lucy K. Helyer, Carman A. Giacomantonio, David M. Waisman, Paola Marcato
Summary: ALDH1A3 regulates the plasminogen activation pathway to promote breast cancer metastasis. Co-expression of ALDH1A3 and tPA is associated with TNBC subtype, high tumor grade, and recurrent metastatic disease.
MOLECULAR ONCOLOGY
(2024)
Article
Oncology
Nayela N. Chowdhury, Yi Yang, Ananya Dutta, Michelle Luo, Zimu Wei, Sara R. Abrahams, Alexey S. Revenko, Fenil Shah, Lindsey A. Miles, Robert J. Parmer, Bas de Laat, Alisa S. Wolberg, James P. Luyendyk, Melissa L. Fishel, Matthew J. Flick
Summary: Pancreatic ductal adenocarcinoma (PDAC) is a highly fatal metastatic disease associated with robust activation of the coagulation and fibrinolytic systems. Primary fibrinolytic protease plasminogen promotes PDAC tumor growth and metastatic potential through engaging plasminogen receptors on tumor cells.
MOLECULAR ONCOLOGY
(2024)
Article
Oncology
Nuria Gendrau-Sanclemente, Agnes Figueras, Kristina Gracova, Alvaro Lahiguera, Elisenda Alsina-Sanchis, Juan A. Marin-Jimenez, August Vidal, Xavier Matias-Guiu, Sergi Fernandez-Gonzalez, Marc Barahona, Lola Marti, Jordi Ponce, Francesc Vinals
Summary: High-grade serous ovarian cancer (HGSOC), the deadliest gynecological malignancy, spreads through transcoelomic dissemination. This study reveals that platelet-derived growth factor receptor beta (PDGFRβ) is essential for the formation of tumorspheres in HGSOC. Inhibition of PDGFRβ blocks the clustering of ovarian cancer cells and prevents peritoneal dissemination.
MOLECULAR ONCOLOGY
(2024)
