Review
Immunology
Yihao Chen, Shengpan Chen, Jianbo Chang, Junji Wei, Ming Feng, Renzhi Wang
Summary: PHE is considered a promising therapeutic target for ICH, but existing research results are conflicting. Therefore, it is necessary to classify, compare, and summarize existing studies on PHE.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, General & Internal
Jawed Nawabi, Sarah Elsayed, Andrea Morotti, Anna Speth, Melanie Liu, Helge Kniep, Rosalie McDonough, Gabriel Broocks, Tobias Faizy, Elif Can, Peter B. Sporns, Jens Fiehler, Bernd Hamm, Tobias Penzkofer, Georg Bohner, Frieder Schlunk, Uta Hanning
Summary: This study found that patients with oral anticoagulant-associated intracerebral hemorrhage (OAC-ICH) had lower levels of perihematomal edema (PHE) in the early stages compared to those with non-oral anticoagulant-associated intracerebral hemorrhage (NON-OAC-ICH), with NOAC patients also exhibiting significantly lower levels of edema expansion distance compared to NON-OAC-ICH patients. The increase in early PHE volume did not increase the likelihood of poor outcomes in OAC-ICH, but was independently associated with poor outcomes in NON-OAC-ICH.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yihao Chen, Chenchen Qin, Jianbo Chang, Yan Lyu, Qinghua Zhang, Zeju Ye, Zhaojian Li, Fengxuan Tian, Wenbin Ma, Junji Wei, Ming Feng, Jianhua Yao, Renzhi Wang
Summary: This study aimed to predict early and delayed perihematomal edema (PHE) expansion in intracerebral hemorrhage (ICH) patients using a machine learning approach. The results showed that the combined ML model performed the best in predicting both early and delayed PHE expansion, suggesting its potential for assisting in the management of neurocritical ICH patients.
EUROPEAN RADIOLOGY
(2023)
Article
Clinical Neurology
Laurent Puy, Antoine Rauch, Vincent Deramecourt, Charlotte Cordonnier, Vincent Berezowski
Summary: This study conducted a postmortem examination to investigate acute microvascular lesions (microbleeds and microinfarcts) in the perihematomal area of patients with spontaneous intracerebral hemorrhage (ICH). It was found that these lesions may contribute to secondary brain tissue damage.
Article
Radiology, Nuclear Medicine & Medical Imaging
Wenliang Guo, Lanxi Meng, Aiyu Lin, Yi Lin, Ying Fu, WanJin Chen, Shaowu Li
Summary: This study found that severe chronic-ischemia cerebral small vessel changes (sciSVC) are associated with progression of perihematomal edema (PHE) and hematoma absorption in hypertensive intracerebral hemorrhage (ICH) patients.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Immunology
Yihao Chen, Chenchen Qin, Jianbo Chang, Yixun Liu, Qinghua Zhang, Zeju Ye, Zhaojian Li, Fengxuan Tian, Wenbin Ma, Junji Wei, Ming Feng, Shengpan Chen, Jianhua Yao, Renzhi Wang
Summary: A deep learning model was used to automatically segment hematoma and perihematomal edema (PHE), and a new definition of delayed perihematomal edema expansion (DPE) was generated. The time course, risk factors, and clinical outcomes of DPE were analyzed. The study found that DPE was associated with worse outcomes, and larger initial hematoma volume was a significant risk factor for DPE formation.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Clinical Neurology
Hanwool Jeon, Moinay Kim, Wonhyoung Park, Joon Seo Lim, Eunyeup Lee, Hyeuk Cha, Jae Sung Ahn, Jeong Hoon Kim, Seok Ho Hong, Ji Eun Park, Eun-Jae Lee, Chul-Woong Woo, Seungjoo Lee
Summary: Intracerebral hemorrhage (ICH) can lead to delayed cerebral edema due to disruption of the blood-brain barrier (BBB), with perihematomal edema (PHE) considered a major factor in morbidity and mortality. The water channel AQP4 on astrocytes plays a crucial role in PHE formation, influenced by reactive oxygen species (ROS) from the hemorrhage. Modulating AQP4 may present a potential therapeutic target for alleviating delayed cerebral edema in ICH.
Article
Clinical Neurology
Lindsey R. Kuohn, Jens Witsch, Thorsten Steiner, Kevin N. Sheth, Hooman Kamel, Babak B. Navi, Alexander E. Merkler, Santosh B. Murthy, Stephan A. Mayer
Summary: This study examined the relationship between different locations (deep versus lobar) of intracerebral hemorrhage (ICH) and early neurological deterioration, hematoma expansion (HE), and outcome. The results showed that lobar ICH location was associated with more common HE and early neurological deterioration, while deep ICH location was associated with smaller hematoma size. However, after adjusting for prognostic variables, deep ICH was associated with worse outcome.
Article
Clinical Neurology
Lotte Sondag, Axel Wolsink, Wilmar M. T. Jolink, Sabine Voigt, Marianne A. A. van Walderveen, Marieke J. H. Wermer, Catharina J. M. Klijn, Floris H. B. M. Schreuder
Summary: This study investigated the association between blood pressure variability and the development of perihematomal edema after intracerebral hemorrhage. The results suggest that blood pressure variability is not associated with edema development, indicating that other mechanisms such as inflammatory processes may play a more important role.
FRONTIERS IN NEUROLOGY
(2023)
Article
Clinical Neurology
Yu-Lun Li, Chu Chen, Li-Juan Zhang, Yi-Neng Zheng, Xin-Ni Lv, Li-Bo Zhao, Qi Li, Fa-Jin Lv
Summary: This study investigated the predictive value of nonradiomics features and machine learning for early perifrom 214 patients with spontaneous ICH. A total of 23 features were selected to establish models, and the MLP model seemed to be the best for prediction of PHE expansion. NCCT models based on radiomics features and machine learning could predict early PHE expansion and improve the discrimination of identifying spontaneous intracerebral hemorrhage patients at risk of early PHE expansion.
WORLD NEUROSURGERY
(2023)
Review
Critical Care Medicine
Sarah Marchina, Jorge A. Trevino-Calderon, Sara Hassani, Joseph M. Massaro, Vasileios-Arsenios Lioutas, Filipa Carvalho, Magdy Selim
Summary: This meta-analysis demonstrates that perihematomal edema (PHE) volume has a weak effect on functional outcome and mortality in patients with intracerebral hemorrhage (ICH), while PHE growth might have a slightly larger impact during the first 72 hours after ictus. Definitive conclusions are limited by the variability of PHE measures, heterogeneity of studies, and different evaluation time points.
NEUROCRITICAL CARE
(2022)
Article
Clinical Neurology
Renzheng Huan, Yi Li, Jiahe Tan, Jun Tang, Ning Huang, Yuan Cheng
Summary: The mean Hounsfield unit (HU) of perihématomal edema (PHE) at 72 hours after intracerebral hemorrhage (ICH) is negatively correlated with poor prognosis, and has a better predictive ability compared to other PHE measures.
WORLD NEUROSURGERY
(2021)
Article
Neurosciences
Jay B. Lusk, Jesse Troy, Nathaniel Nowacki, Peter G. Kranz, Maureen Maughan, Daniel T. Laskowitz, Michael L. James
Summary: This study provides initial insights into the longitudinal associations between neuroinflammatory biomarkers and the development of perihematomal edema and secondary tissue injury after ICH in humans. The identified biomarkers could potentially be used as surrogate markers for treatment effect in novel therapies targeting neuroinflammation after ICH.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2022)
Article
Clinical Neurology
Andrea Morotti, Giorgio Busto, Elisa Scola, Edoardo Carlesi, Francesca Di Pasquale, Ilaria Casetta, Enrico Fainardi
Summary: This study aimed to characterize the relationship between perihematomal perfusion and irregular ICH shape. The findings suggest that perihematomal hypoperfusion may contribute to the CT appearance of acute ICH, with CBF<20 mL/100 g/min independently associated with irregular shape.
Article
Critical Care Medicine
Neal S. Parikh, Arun Jesudian, Hooman Kamel, Daniel F. Hanley, Wendy C. Ziai, Santosh B. Murthy
Summary: This study found that a liver fibrosis score was not associated with perihematomal edema volume or growth in patients with primary intracerebral hemorrhage.
NEUROCRITICAL CARE
(2021)