The Origin of the Burst-Suppression Paradigm in Treatment of Status Epilepticus

After electroencephalography (EEG) was introduced in hospitals, early literature recognized burst-suppression pattern (BSP) as a distinctive EEG pattern characterized by intermittent high-power oscillations alternating with isoelectric periods in coma and epileptic encephalopathies of childhood or the pattern could be induced by general anesthesia and hypothermia. The term was introduced by Swank and Watson in 1949 but was initially described by Derbyshire et al. in 1936 in their study about the anesthetic effects of tribromoethanol. Once the EEG/BSP pattern emerged in the literature as therapeutic goal in refractory status epilepticus, researchers began exploring whether the depth of EEG suppression correlated with improved seizure control and clinical outcomes. We can conclude that, from a historical perspective, the evidence to suppress the brain to a BSP when treating status epilepticus is inconclusive.

Automated summary

Burst-suppression pattern (BSP) is a distinctive EEG pattern associated with coma, epileptic encephalopathies, and induced by general anesthesia and hypothermia. Research has explored the correlation between depth of EEG suppression and improved seizure control and clinical outcomes. From a historical perspective, the evidence for suppressing the brain to a BSP when treating status epilepticus is inconclusive.