Formation of templated inclusions in a forebrain α-synuclein mouse model is independent of LRRK2
出版年份 2023 全文链接
标题
Formation of templated inclusions in a forebrain α-synuclein mouse model is independent of LRRK2
作者
关键词
-
出版物
NEUROBIOLOGY OF DISEASE
Volume 188, Issue -, Pages 106338
出版商
Elsevier BV
发表日期
2023-10-30
DOI
10.1016/j.nbd.2023.106338
参考文献
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Pathological α-synuclein recruits LRRK2 expressing pro-inflammatory monocytes to the brain
- (2022) Enquan Xu et al. Molecular Neurodegeneration
- Association of a common genetic variant with Parkinson’s disease is mediated by microglia
- (2022) Rebekah G. Langston et al. Science Translational Medicine
- Computational modeling of tau pathology spread reveals patterns of regional vulnerability and the impact of a genetic risk factor
- (2021) Eli J. Cornblath et al. Science Advances
- Inhibition of LRRK2 kinase activity promotes anterograde axonal transport and presynaptic targeting of α-synuclein
- (2021) Charlotte F. Brzozowski et al. Acta Neuropathologica Communications
- LRRK2 and Protein Aggregation in Parkinson’s Disease: Insights From Animal Models
- (2020) Dylan J. Dues et al. Frontiers in Neuroscience
- LRRK2 mediates microglial neurotoxicity via NFATc2 in rodent models of synucleinopathies
- (2020) Changyoun Kim et al. Science Translational Medicine
- LRRK2 inhibition does not impart protection from α-synuclein pathology and neuron death in non-transgenic mice
- (2019) Michael X. Henderson et al. Acta Neuropathologica Communications
- Pathogenic alpha-synuclein aggregates preferentially bind to mitochondria and affect cellular respiration
- (2019) Xinhe Wang et al. Acta Neuropathologica Communications
- LRRK2 modifies α-syn pathology and spread in mouse models and human neurons
- (2019) Gregor Bieri et al. ACTA NEUROPATHOLOGICA
- Spread of α-synuclein pathology through the brain connectome is modulated by selective vulnerability and predicted by network analysis
- (2019) Michael X. Henderson et al. NATURE NEUROSCIENCE
- Alzheimer’s disease tau is a prominent pathology in LRRK2 Parkinson’s disease
- (2019) Michael X. Henderson et al. Acta Neuropathologica Communications
- Identification of novel risk loci, causal insights, and heritable risk for Parkinson's disease: a meta-analysis of genome-wide association studies
- (2019) Mike A Nalls et al. LANCET NEUROLOGY
- Mutant LRRK2 mediates peripheral and central immune responses leading to neurodegeneration in vivo
- (2018) Elena Kozina et al. BRAIN
- Peripheral monocyte entry is required for alpha-Synuclein induced inflammation and Neurodegeneration in a model of Parkinson disease
- (2018) Ashley S. Harms et al. EXPERIMENTAL NEUROLOGY
- LRRK2 activity does not dramatically alter α-synuclein pathology in primary neurons
- (2018) Michael X. Henderson et al. Acta Neuropathologica Communications
- G2019S LRRK2 mutation facilitates α-synuclein neuropathology in aged mice
- (2018) Salvatore Novello et al. NEUROBIOLOGY OF DISEASE
- Quality Over Quantity: Advantages of Using Alpha-Synuclein Preformed Fibril Triggered Synucleinopathy to Model Idiopathic Parkinson’s Disease
- (2018) Megan F. Duffy et al. Frontiers in Neuroscience
- Isolated nigral degeneration without pathological protein aggregation in autopsied brains with LRRK2 p.R1441H homozygous and heterozygous mutations
- (2018) Masashi Takanashi et al. Acta Neuropathologica Communications
- G2019S LRRK2 enhances the neuronal transmission of tau in the mouse brain
- (2017) An Phu Tran Nguyen et al. HUMAN MOLECULAR GENETICS
- Neuropathology of genetic synucleinopathies with parkinsonism: Review of the literature
- (2017) Susanne A. Schneider et al. MOVEMENT DISORDERS
- The Role of Astrocyte Dysfunction in Parkinson’s Disease Pathogenesis
- (2017) Heather D.E. Booth et al. TRENDS IN NEUROSCIENCES
- LRRK2 Antisense Oligonucleotides Ameliorate α-Synuclein Inclusion Formation in a Parkinson’s Disease Mouse Model
- (2017) Hien Tran Zhao et al. Molecular Therapy-Nucleic Acids
- The G2019S LRRK2 mutation increases myeloid cell chemotactic responses and enhances LRRK2 binding to actin-regulatory proteins
- (2015) Mark S. Moehle et al. HUMAN MOLECULAR GENETICS
- Differential LRRK2 expression in the cortex, striatum, and substantia nigra in transgenic and nontransgenic rodents
- (2014) Andrew B. West et al. JOURNAL OF COMPARATIVE NEUROLOGY
- Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease
- (2014) Mike A Nalls et al. NATURE GENETICS
- Addition of exogenous α-synuclein preformed fibrils to primary neuronal cultures to seed recruitment of endogenous α-synuclein to Lewy body and Lewy neurite–like aggregates
- (2014) Laura A Volpicelli-Daley et al. Nature Protocols
- LRRK2 phosphorylates novel tau epitopes and promotes tauopathy
- (2013) Rachel M. Bailey et al. ACTA NEUROPATHOLOGICA
- Distinct α-Synuclein Strains Differentially Promote Tau Inclusions in Neurons
- (2013) Jing L. Guo et al. CELL
- Neurodegenerative phenotypes in an A53T -synuclein transgenic mouse model are independent of LRRK2
- (2012) J. P. L. Daher et al. HUMAN MOLECULAR GENETICS
- LRRK2 kinase inhibition prevents pathological microglial phagocytosis in response to HIV-1 Tat protein
- (2012) Daniel F Marker et al. Journal of Neuroinflammation
- LRRK2 Inhibition Attenuates Microglial Inflammatory Responses
- (2012) M. S. Moehle et al. JOURNAL OF NEUROSCIENCE
- Parkinson's disease-linked leucine-rich repeat kinase 2(R1441G) mutation increases proinflammatory cytokine release from activated primary microglial cells and resultant neurotoxicity
- (2012) F. Gillardon et al. NEUROSCIENCE
- High LRRK2 Levels Fail to Induce or Exacerbate Neuronal Alpha-Synucleinopathy in Mouse Brain
- (2012) Martin C. Herzig et al. PLoS One
- Incidental Lewy body disease: Clinical comparison to a control cohort
- (2010) Charles H. Adler et al. MOVEMENT DISORDERS
- Leucine-Rich Repeat Kinase 2 Gene-Associated Disease: Redefining Genotype-Phenotype Correlation
- (2010) Christian Wider et al. Neurodegenerative Diseases
- Leucine-Rich Repeat Kinase 2 Regulates the Progression of Neuropathology Induced by Parkinson's-Disease-Related Mutant α-synuclein
- (2009) Xian Lin et al. NEURON
- Worldwide frequency of G2019S LRRK2 mutation in Parkinson's disease: A systematic review
- (2009) L. Correia Guedes et al. PARKINSONISM & RELATED DISORDERS
- Zeroing in on LRRK2-linked pathogenic mechanisms in Parkinson's disease
- (2008) Saskia Biskup et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Phenotype, genotype, and worldwide genetic penetrance of LRRK2-associated Parkinson's disease: a case-control study
- (2008) Daniel G Healy et al. LANCET NEUROLOGY
- The Sydney multicenter study of Parkinson's disease: The inevitability of dementia at 20 years
- (2008) Mariese A. Hely et al. MOVEMENT DISORDERS
- Familial parkinsonism: Study of original Sagamihara PARK8 (I2020T) kindred with variable clinicopathologic outcomes
- (2008) Kazuko Hasegawa et al. PARKINSONISM & RELATED DISORDERS
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