Alzheimer’s disease-like APP processing in wild-type mice identifies synaptic defects as initial steps of disease progression

Reduction in Post-Synaptic Scaffolding PSD-95 and SAP-102 Protein Levels in the Alzheimer Inferior Temporal Cortex is Correlated with Disease Pathology

(2017) Dustin T. Proctor et al.   JOURNAL OF ALZHEIMERS DISEASE

Neuronal Circuits for Fear Expression and Recovery: Recent Advances and Potential Therapeutic Strategies

(2015) Cyril Dejean et al.   BIOLOGICAL PSYCHIATRY

Cerebrospinal Fluid Biomarkers of Neurovascular Dysfunction in Mild Dementia and Alzheimer'S Disease

(2015) Melanie D Sweeney et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Acute amnestic encephalopathy in amyloid-β oligomer–injected mice is due to their widespread diffusion in vivo

(2015) Stéphane Epelbaum et al.   NEUROBIOLOGY OF AGING

Mapping fear memory consolidation and extinction-specific expression of JunB

(2015) Kasia Radwanska et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Genomic mosaicism with increased amyloid precursor protein (APP) gene copy number in single neurons from sporadic Alzheimer's disease brains

(2015) Diane M Bushman et al.   eLife

Intracerebral Gene Therapy Using AAVrh.10-hARSA Recombinant Vector to Treat Patients with Early-Onset Forms of Metachromatic Leukodystrophy: Preclinical Feasibility and Safety Assessments in Nonhuman Primates

(2015) Michel Zerah et al.   Human Gene Therapy Clinical Development

Acute function of secreted amyloid precursor protein fragment APPsα in synaptic plasticity

(2014) Meike Hick et al.   ACTA NEUROPATHOLOGICA

Early Alzheimer's Disease Neuropathology Detected by Proton MR Spectroscopy

(2014) Melissa E. Murray et al.   JOURNAL OF NEUROSCIENCE

Single App knock-in mouse models of Alzheimer's disease

(2014) Takashi Saito et al.   NATURE NEUROSCIENCE

Two Phase 3 Trials of Bapineuzumab in Mild-to-Moderate Alzheimer's Disease

(2014) Stephen Salloway et al.   NEW ENGLAND JOURNAL OF MEDICINE

Encoding and storage of spatial information in the retrosplenial cortex

(2014) R. Czajkowski et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alzheimer’s disease drug-development pipeline: few candidates, frequent failures

(2014) Jeffrey L Cummings et al.   Alzheimers Research & Therapy

Comparative analysis of single and combined APP/APLP knockouts reveals reduced spine density in APP-KO mice that is prevented by APPsα expression

(2014) Sascha W Weyer et al.   Acta Neuropathologica Communications

Amyloid- 1-42 Slows Clearance of Synaptically Released Glutamate by Mislocalizing Astrocytic GLT-1

(2013) A. Scimemi et al.   JOURNAL OF NEUROSCIENCE

A  induces astrocytic glutamate release, extrasynaptic NMDA receptor activation, and synaptic loss

(2013) M. Talantova et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NMDA receptor subunit composition determines beta-amyloid-induced neurodegeneration and synaptic loss

(2013) C Tackenberg et al.   Cell Death & Disease

An Update of Animal Models of Alzheimer Disease with a Reevaluation of Plaque Depositions

(2013) Jung-Eun Lee et al.   Experimental Neurobiology

Hyperphosphorylation of Tau Induced by Naturally Secreted Amyloid-β at Nanomolar Concentrations Is Modulated by Insulin-dependent Akt-GSK3β Signaling Pathway

(2012) Takayoshi Tokutake et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Roles of the amyloid precursor protein family in the peripheral nervous system

(2012) John H. Caldwell et al.   MECHANISMS OF DEVELOPMENT

A mutation in APP protects against Alzheimer’s disease and age-related cognitive decline

(2012) Thorlakur Jonsson et al.   NATURE

Spatial learning and memory impairment and increased locomotion in a transgenic amyloid precursor protein mouse model of Alzheimer's disease

(2011) J.M. Walker et al.   BEHAVIOURAL BRAIN RESEARCH

Brain Oligomeric β-Amyloid but Not Total Amyloid Plaque Burden Correlates With Neuronal Loss and Astrocyte Inflammatory Response in Amyloid Precursor Protein/Tau Transgenic Mice

(2011) Bibiana DaRocha-Souto et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Soluble A  Oligomers Inhibit Long-Term Potentiation through a Mechanism Involving Excessive Activation of Extrasynaptic NR2B-Containing NMDA Receptors

(2011) S. Li et al.   JOURNAL OF NEUROSCIENCE

The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics

(2011) Eric Karran et al.   NATURE REVIEWS DRUG DISCOVERY

Roles of amyloid precursor protein family members in neuroprotection, stress signaling and aging

(2011) Donat Kögel et al.   EXPERIMENTAL BRAIN RESEARCH

The Large Hydrophilic Loop of Presenilin 1 Is Important for Regulating γ-Secretase Complex Assembly and Dictating the Amyloid β Peptide (Aβ) Profile without Affecting Notch Processing

(2010) Johanna Wanngren et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pittsburgh Compound B Imaging and Prediction of Progression From Cognitive Normality to Symptomatic Alzheimer Disease

(2009) John C. Morris et al.   ARCHIVES OF NEUROLOGY

Cognitive Decline and Brain Volume Loss as Signatures of Cerebral Amyloid-β Peptide Deposition Identified With Pittsburgh Compound B

(2009) Martha Storandt et al.   ARCHIVES OF NEUROLOGY

A new amyloid β variant favoring oligomerization in Alzheimer's-type dementia

(2008) Takami Tomiyama et al.   ANNALS OF NEUROLOGY

Episodic memory deficits are not related to altered glutamatergic synaptic transmission and plasticity in the CA1 hippocampus of the APPswe/PS1ΔE9-deleted transgenic mice model of β-amyloidosis

(2008) Arturas Volianskis et al.   NEUROBIOLOGY OF AGING