Article
Cell Biology
Jidong Sun, Chen Pu, ErWan Yang, Hongchen Zhang, Yuan Feng, Peng Luo, Yuefan Yang, Lei Zhang, Xia Li, Xiaofan Jiang, Shuhui Dai
Summary: Intracerebral hemorrhage (ICH) is a deadly stroke type, and inflammation caused by macrophages/microglia (M/Ms) activation is a leading cause of brain damage after ICH. Resveratrol (RSV) has anti-inflammatory effects and has been evaluated in various central nervous system disease models. This study aimed to assess the role of RSV in ICH and investigate its downstream mechanism involving Sirt3.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2023)
Article
Clinical Neurology
Fenghui Ye, Jinting Yang, Ya Hua, Richard F. Keep, Guohua Xi
Summary: Using a Tmem119-EGFP transgenic mouse model, the study found that the number of perihematomal microglia significantly decreased on day 1 after ICH, but markedly increased by day 3 and day 7. Injection of iron or thrombin induced microglia death or proliferation, respectively.
Review
Neurosciences
Rentang Bi, Zhi Fang, Mingfeng You, Quanwei He, Bo Hu
Summary: Small glial cells play a crucial role in both tissue damage and repair processes after ICH, with the proportion of glial cell phenotypes determining the progression of brain tissue damage or repair.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Pharmacology & Pharmacy
Jingwei Zheng, Haijian Wu, Xiaoyu Wang, Guoqiang Zhang, Jia'nan Lu, Weilin Xu, Shenbin Xu, Yuanjian Fang, Anke Zhang, Anwen Shao, Sheng Chen, Zhen Zhao, Jianmin Zhang, Jun Yu
Summary: This study aimed to investigate the role of microglia-astrocyte interaction in glial scar formation after intracerebral hemorrhage (ICH). The findings suggest that sustained microglial depletion during the early stage of ICH leads to disorganized astrocytic scar, enhanced neutrophil infiltration, and impaired tissue repair. Mechanistically, microglia-derived insulin like growth factor 1 (IGF1) modulates astrocytic scar formation via mechanistic target of rapamycin (mTOR) signaling activation. Additionally, repopulating microglia more strongly activate mTOR signaling, facilitating a more protective scar formation. At the chronic stage of ICH, the overall net effect of astrocytic scar changes from protective to destructive. Early-stage IGF1/OPN treatment combined with late-stage PLX3397 treatment is proposed as a promising therapeutic strategy.
JOURNAL OF PHARMACEUTICAL ANALYSIS
(2023)
Article
Clinical Neurology
Anan Shtaya, Leslie R. Bridges, Rebecca Williams, Sarah Trippier, Liqun Zhang, Anthony C. Pereira, James A. R. Nicoll, Delphine Boche, Atticus H. Hainsworth
Summary: The study identified an anti-inflammatory process occurring alongside neuroinflammation post-sICH in clinical patients, involving native microglia and blood monocytes. This novel pathway offers therapeutic targets and a treatment opportunity window for delivering therapeutics through invading monocytes during 3-5 days post-sICH.
Review
Immunology
Jiachen Liu, Lirong Liu, Xiaoyu Wang, Rundong Jiang, Qinqin Bai, Gaiqing Wang
Summary: Research suggests that microglia may shift towards a pro-inflammatory phenotype following intracerebral hemorrhage, while anti-inflammatory microglia with neuroprotective effects are suppressed. Driving microglia towards an anti-inflammatory phenotype could potentially restrict inflammation and engulf cellular debris.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Geriatrics & Gerontology
Noah Watson, Frederick Bonsack, Sangeetha Sukumari-Ramesh
Summary: Intracerebral hemorrhage (ICH) is a severe type of stroke with high mortality and morbidity rates. Advanced age is a major risk factor for ICH, but the molecular changes in the aging brain after ICH are largely unknown. This limits the translation of preclinical studies into potential human treatments.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Immunology
Yang Wu, Qing Hu, Xiaoliang Wang, Hongbo Cheng, Jiegang Yu, Yang Li, Jianing Luo, Qingjiu Zhang, Jianliang Wu, Gengshen Zhang
Summary: Pterostilbene attenuates neuroinflammation and brain injury after intracerebral hemorrhage (ICH) in mice, potentially through regulating microglial mitochondrial dynamics.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Honglei Ren, Yan Pan, Danni Wang, Hongying Hao, Ranran Han, Caiyun Qi, Wenjun Zhang, Wenyan He, Fu-Dong Shi, Qiang Liu
Summary: The upregulation of CD22 in microglia plays a crucial role in intracerebral hemorrhage (ICH) and its blockade leads to reduced neurological deficits, brain lesion, and hematoma volume. CD22 blockade enhances the phagocytosis activity and alternative activation markers in microglia after ICH. Its protective effects are dependent on microglial activity and the involvement of SYK pathway.
PHARMACOLOGICAL RESEARCH
(2023)
Article
Immunology
Yonghe Zheng, Linfeng Fan, Siqi Xia, Qiguo Yang, Zhihua Zhang, Huaijun Chen, Hanhai Zeng, Xiongjie Fu, Yucong Peng, Chaoran Xu, Kaibo Yu, Fuyi Liu, Shenglong Cao
Summary: The study shows that the complement C1q/C3-CR3 signaling is upregulated after ICH, and the activation of this signaling pathway aggravates brain injury following ICH. Additionally, minocycline exerts neuroprotective effects on brain injury partly due to inhibition of the C1q/C3-CR3 signaling pathway.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Shuhui Dai, Jialiang Wei, Hongchen Zhang, Peng Luo, Yuefan Yang, Xiaofan Jiang, Zhou Fei, Wenbin Liang, Jianli Jiang, Xia Li
Summary: Intermittent fasting (IF) protects against intracerebral hemorrhage (ICH) by suppressing inflammatory responses and cellular injuries through the Sirt3/Nrf2/HO-1 pathway.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Cell Biology
Jianfeng Zhuang, Yang Cao, Gengyin Guo, Maogui Li, Tongfu Zhang, Dong He, Jinyan Chen, Keke Zhang, Zhen Zhang
Summary: Hematoma-induced neuroinflammation is a major cause of poor prognosis in intracerebral hemorrhage (ICH). In this study, the role of BACE1 in microglial phagocytosis and inflammatory features in ICH was investigated. The results suggest that targeted inhibition of the BACE1/STAT3 pathway may be a promising strategy for the treatment of ICH-induced neurological injury.
Article
Neurosciences
Yating He, Haijie Liu, Ye Liu, Xiaowen Li, Mengmeng Fan, Kaibin Shi, Minshu Li
Summary: O-GlcNAcylation plays a crucial role in suppressing the inflammatory response, enhancing BBB integrity, and reducing edema after ICH. It can reduce cerebral hematoma formation, improve neural function, and regulate immune cells in the central nervous system.
Article
Neurosciences
Demao Cao, Bing Li, Cheng Cao, Juyi Zhang, Xiang Li, Haiying Li, Zhengquan Yu, Haitao Shen, Ming Ye
Summary: In this study, the researchers investigated the role and molecular mechanism of Caveolin-1 (CAV1) in brain injury using a rat autologous whole blood injection model and an in vitro model of intracerebral hemorrhage (ICH). The results showed that CAV1 overexpression worsened neurological dysfunction and cellular apoptosis in ICH rats, while CAV1 knockdown ameliorated these effects. Additionally, CAV1 overexpression aggravated neuroinflammation, while CAV1 knockdown inhibited microglia activation and neuroinflammatory response. The in vitro experiments also revealed the involvement of CAV1 in regulating the C-Src, IKK-beta, and NF-kappa B signaling pathways.
EXPERIMENTAL NEUROLOGY
(2023)
Article
Immunology
Qian Li, Xi Lan, Xiaoning Han, Frederick Durham, Jieru Wan, Abigail Weiland, Raymond C. Koehler, Jian Wang
Summary: IL-10 regulates microglial phagocytosis and monocyte-derived macrophage infiltration after ICH, with CD36 identified as a key phagocytosis effector regulated by IL-10. Leveraging IL-10 signaling may provide a useful strategy for accelerating hematoma clearance and improving neurologic outcome.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Article
Neuroimaging
Johannes Kaesmacher, Adnan Mujanovic, Kilian Treurniet, Manon Kappelhof, Thomas R. Meinel, Pengfei Yang, Jianmin Liu, Yongwei Zhang, Wenjie Zi, Qingwu Yang, Raul G. Nogueira, Kazumi Kimura, Yuji Matsumaru, Kentaro Suzuki, Bernard Yan, Peter J. Mitchell, Zhongrong Miao, Yvo B. W. E. M. Roos, Charles B. L. M. Majoie, Jan Gralla, Jeffrey L. Saver, Urs Fischer
Summary: This study investigated the acceptable level of uncertainty for experienced stroke clinicians in deciding whether to administer intravenous thrombolysis (IVT) before endovascular treatment (EVT). The results showed that clinicians would generally feel comfortable skipping IVT if there was reasonable comparability between IVT+EVT and EVT alone, with no more than 3% of patients being unable to achieve functional independence at 90 days due to skipping IVT.
JOURNAL OF NEUROINTERVENTIONAL SURGERY
(2023)
Review
Cell Biology
Ruoyu Zhang, Chen Sun, Yunze Han, Leo Huang, Honghui Sheng, Jing Wang, Yuqing Zhang, Jonathan Lai, Jiahao Yuan, Xuemei Chen, Chao Jiang, Fuyuan Wu, Junmin Wang, Xiaochong Fan, Jian Wang
Summary: This review summarizes the latest research progress of autophagy and NETosis in COVID-19 and provides an in-depth explanation of their underlying mechanisms. The relationship between autophagy and NETosis is explored, and potential treatment targets and options are discussed.
Article
Clinical Neurology
Jiacheng Huang, Maolin Wang, Fengli Li, Weilin Kong, Da Liu, Huagang Li, Peiyang Zhou, Zhizhong Yan, Yan Wang, Jiaxing Song, Weidong Luo, Shuai Liu, Linyu Li, Jinrong Hu, Yan Tian, Zhongming Qiu, Rui Xu, Wouter J. Schonewille, Wenjie Zi, Qingwu Yang
Summary: This study identified potential modifiable risk factors for early mortality in patients with basilar artery occlusion, including recanalization failure, herniation, gastrointestinal hemorrhage, and pneumonia.
CEREBROVASCULAR DISEASES
(2023)
Article
Clinical Neurology
Wenjie Zi, Jiaxing Song, Zhongming Qiu, Weilin Kong, Jiacheng Huang, Weidong Luo, Shuai Liu, Hongfei Sang, Jie Yang, Linyu Li, Yan Tian, Jinrong Hu, Jeffrey L. Saver, Raul G. Nogueira, Fengli Li, Qingwu Yang
Summary: This study aims to compare the efficacy and safety of tirofiban with aspirin in patients with acute ischemic stroke. The study will be conducted in multiple stroke centers in China and will evaluate the functional outcomes and potential safety issues in patients after 90 days of treatment.
INTERNATIONAL JOURNAL OF STROKE
(2023)
Article
Immunology
Lexing Xie, Shuang Zhang, Li Huang, Zhouzhou Peng, Hui Lu, Qian He, Ru Chen, Linlin Hu, Bingqiao Wang, Baoliang Sun, Qingwu Yang, Qi Xie
Summary: Stroke is a leading cause of death and disability worldwide. Researchers have found that peripheral immune cells infiltrate the brain and cause inflammation after cerebral ischemia. However, it is still unclear how and when these immune cells affect the central inflammatory response, and whether interventions targeting these processes can reduce ischemia-reperfusion injury.
BRAIN BEHAVIOR AND IMMUNITY
(2023)
Article
Cell Biology
Li-Min Wang, Zhi-Hua Liu, Hong-Lei Ren, Xue-Mei Chen, Jun-Min Wang, Hui-Min Cai, Li-Ping Wei, Hui-Hong Tian, Jian Wang, Li-Juan Wang
Summary: This study successfully established a mouse model of recurrent ICH and found that mice with bilateral striatal hemorrhage showed worse neurological function, delayed recovery in locomotor function and cognitive dysfunction compared to mice with unilateral striatal hemorrhage, which could well simulate the clinical situation.
NEURAL REGENERATION RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Qiong Chen, Ting Zhou, Jun-jie Yuan, Xiao-yi Xiong, Xue-hui Liu, Zong-ming Qiu, Lin-lin Hu, Hui Lu, Qian He, Chang Liu, Qing-wu Yang
Summary: This study investigated the metabolic alterations during ischemia-reperfusion injury using metabolomic analysis. A total of 82 differentially expressed metabolites were identified, with some significantly elevated in the reperfusion group. Metabolomics pathway analysis revealed the importance of glycerophospholipid metabolism, linoleic acid metabolism, pyrimidine metabolism, and galactose metabolism in the response to cerebral ischemia-reperfusion. This study provides important insights into the metabolic changes induced by cerebral ischemia-reperfusion.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Neurosciences
Zhouzhou Peng, Jiaxing Song, Linyu Li, Changwei Guo, Jie Yang, Weilin Kong, Jiacheng Huang, Jinrong Hu, Shuai Liu, Yan Tian, Dahong Yang, Fengli Li, Wenjie Zi, Dongjing Xie, Qingwu Yang
Summary: This study aimed to evaluate the association between stress hyperglycemia ratio (SHR) and clinical outcomes at 90 days in acute ischemic stroke due to large vessel occlusion receiving endovascular treatment. The study found that SHR was negatively associated with the odds of achieving favorable functional outcomes at 90 days.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Immunology
Shaoshuai Wang, Xiuhua Ren, Junmin Wang, Qinfeng Peng, Xiaoyu Niu, Chunhua Song, Changsheng Li, Chao Jiang, Weidong Zang, Marietta Zille, Xiaochong Fan, Xuemei Chen, Jian Wang
Summary: This study aimed to characterize brain tissue autofluorescence in three models of acute brain injury and establish a simple and effective method to block autofluorescence. The results showed that pretreatment with SBB could significantly reduce brain tissue autofluorescence without affecting specific fluorescence signals, improving the signal-to-noise ratio of fluorescence imaging.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Medicine, General & Internal
Zhiyi Chen, Xuerong Liu, Qingwu Yang, Yan-Jiang Wang, Kuan Miao, Zheng Gong, Yang Yu, Artemiy Leonov, Chunlei Liu, Zhengzhi Feng, Hu Chuan-Peng
Summary: This study systematically evaluated the clinical applicability and reporting quality of neuroimaging-based AI models for psychiatric diagnosis. The results showed high risk of bias and poor reporting quality. The application of these models in clinical practice still faces challenges and needs to address the risk of bias and improve reporting quality.
Review
Geriatrics & Gerontology
Yinrou Huang, Mengke Zhao, Xuemei Chen, Ruoyu Zhang, Anh Le, Michael Hong, Yufei Zhang, Lin Jia, Weidong Zang, Chao Jiang, Junmin Wang, Xiaochong Fan, Jian Wang
Summary: In this review, the biological properties and pathogenic functions of key metabolites in 12 central nervous system disorders are summarized. The changes in the metabolic pathway of tryptophan and potential therapeutic strategies targeting this pathway are discussed. This comprehensive review provides valuable guidance for future research on neuropsychiatric disorders.
Article
Geriatrics & Gerontology
Zhiying Zhang, Yinuo Li, Juyuan Shi, Li Zhu, Yinming Dai, Peiji Fu, Simon Liu, Michael Hong, Jiewen Zhang, Jian Wang, Chao Jiang
Summary: Modulators of the S1PR have potential therapeutic effects on stroke, but their mechanisms and value for ICH therapy need further exploration. This study found that siponimod could reduce brain injury and improve neurological function, as well as inhibit immunoinflammatory responses. These results provide preclinical evidence for future investigation of immunomodulators.
Article
Clinical Neurology
Chenhao Zhao, Ting Hu, Weilin Kong, De Yang, Junfang Wan, Kefeng Lv, Jiasheng Liao, Zhao Chen, He Jiang, Deping Wu, Ping Yang, Wenjie Zi, Fengli Li, Qingwu Yang
Summary: This study aimed to evaluate the impact of FPE on efficacy and safety for patients with acute basilar artery occlusion (BAO). The results showed that achieving FPE was strongly associated with favorable clinical outcomes, lower mortality rate, and shorter time to recanalization. Compared with final successful reperfusion, FPE also independently contributed to favorable outcomes.
JOURNAL OF NEUROSURGERY
(2023)
Article
Clinical Neurology
Jie Yang, Fengli Li, Zhongming Qiu, Yan Wang, Jun Luo, Youlin Wu, Guoyong Zeng, Yue Wan, Shuai Liu, Chengsong Yue, Jiaxing Song, Weidong Luo, Chang Liu, Linyu Li, Ruidi Sun, Jiacheng Huang, Hongfei Sang, Chenhao Zhao, Qingwu Yang, Wenjie Zi
Summary: The study aimed to investigate the efficacy and safety of combining endovascular treatment (EVT) with standard medical treatment (SMT) in Chinese patients with acute basilar artery occlusion (BAO) within 6 hours of occlusion. Patients were divided into SMT-alone group or EVT+SMT group. Results showed that EVT was associated with a higher rate of favorable functional outcome and a lower proportion of deaths. Predictors of favorable outcome in the EVT+SMT group included younger age, lower baseline National Institutes of Health Stroke Scale score, higher baseline posterior circulation Alberta Stroke Program Early CT Score, absence of diabetes mellitus, and modified Thrombolysis in Cerebral Infarction scores 2b-3.
JOURNAL OF NEUROSURGERY
(2023)
Article
Biochemistry & Molecular Biology
Chengli Liu, Kun Yao, Qi Tian, Yujia Guo, Guijun Wang, Peibang He, Jianfeng Wang, Jian Wang, Zhan Zhang, Mingchang Li
Summary: This study revealed the impact of CXCR4 and P-BTK on NLRP3-mediated pyroptosis and lipid peroxidation in SAH, both in vivo and in vitro. Inhibition of the CXCR4-BTK axis can attenuate NLRP3-mediated pyroptosis and lipid peroxidation by regulating NF-kappa B activation in EBI after SAH.
