Selective IL-27 production by intestinal regulatory T cells permits gut-specific regulation of TH17 cell immunity

Gut epithelial IL-27 confers intestinal immunity through the induction of intraepithelial lymphocytes

(2021) Chia-Hao Lin et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Insulin signaling establishes a developmental trajectory of adipose regulatory T cells

(2021) Yangyang Li et al.   NATURE IMMUNOLOGY

cGAS restricts colon cancer development by protecting intestinal barrier integrity

(2021) Shuiqing Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

BACH2 drives quiescence and maintenance of resting Treg cells to promote homeostasis and cancer immunosuppression

(2020) Francis M. Grant et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Single-Cell Transcriptomics of Regulatory T Cells Reveals Trajectories of Tissue Adaptation

(2019) Ricardo J. Miragaia et al.   IMMUNITY

FAM64A positively regulates STAT3 activity to promote Th17 differentiation and colitis-associated carcinogenesis

(2019) Zhi-Sheng Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TCF1 and LEF1 Control Treg Competitive Survival and Tfr Development to Prevent Autoimmune Diseases

(2019) Bi-Huei Yang et al.   Cell Reports

Design and application of single-cell RNA sequencing to study kidney immune cells in lupus nephritis

(2019) Deepak A. Rao et al.   Nature Reviews Nephrology

Brain regulatory T cells suppress astrogliosis and potentiate neurological recovery

(2018) Minako Ito et al.   NATURE

Reciprocal Expression of IL-35 and IL-10 Defines Two Distinct Effector Treg Subsets that Are Required for Maintenance of Immune Tolerance

(2017) Xundong Wei et al.   Cell Reports

Interleukin-27-Producing CD4 + T Cells Regulate Protective Immunity during Malaria Parasite Infection

(2016) Daisuke Kimura et al.   IMMUNITY

Interleukin-27 as a Novel Therapy for Inflammatory Bowel Disease

(2016) Caroline Andrews et al.   INFLAMMATORY BOWEL DISEASES

Citrobacter rodentium mouse model of bacterial infection

(2016) Valerie F Crepin et al.   Nature Protocols

The Immunobiology of Interleukin-27

(2015) Hiroki Yoshida et al.   Annual Review of Immunology

A Distinct Function of Regulatory T Cells in Tissue Protection

(2015) Nicholas Arpaia et al.   CELL

MyD88 Adaptor-Dependent Microbial Sensing by Regulatory T Cells Promotes Mucosal Tolerance and Enforces Commensalism

(2015) Sen Wang et al.   IMMUNITY

Murine CD83-positive T cells mediate suppressor functions in vitro and in vivo

(2015) Simon Kreiser et al.   IMMUNOBIOLOGY

The microbiota regulates type 2 immunity through ROR t+ T cells

(2015) C. Ohnmacht et al.   SCIENCE

Individual intestinal symbionts induce a distinct population of ROR + regulatory T cells

(2015) E. Sefik et al.   SCIENCE

IFNγ Signaling Endows DCs with the Capacity to Control Type I Inflammation during Parasitic Infection through Promoting T-bet+ Regulatory T Cells

(2015) Hyang-Mi Lee et al.   PLoS Pathogens

Transient Ablation of Regulatory T cells Improves Antitumor Immunity in Colitis-Associated Colon Cancer

(2014) E. Pastille et al.   CANCER RESEARCH

Continuous requirement for the TCR in regulatory T cell function

(2014) Andrew G Levine et al.   NATURE IMMUNOLOGY

A Special Population of Regulatory T Cells Potentiates Muscle Repair

(2013) Dalia Burzyn et al.   CELL

IL-27, targeting antigen-presenting cells, promotes Th17 differentiation and colitis in mice

(2013) A Visperas et al.   Mucosal Immunology

The Cytokines Interleukin 27 and Interferon-γ Promote Distinct Treg Cell Populations Required to Limit Infection-Induced Pathology

(2012) Aisling O’Hara Hall et al.   IMMUNITY

Immune response and immunopathology during toxoplasmosis

(2012) Christopher D. Dupont et al.   Seminars in Immunopathology

Differentiation and function of Foxp3+ effector regulatory T cells

(2012) Erika Cretney et al.   TRENDS IN IMMUNOLOGY

Control of TH17 cells occurs in the small intestine

(2011) Enric Esplugues et al.   NATURE

IL-27 promotes T cell–dependent colitis through multiple mechanisms

(2010) Jennifer H. Cox et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Differential Roles of Interleukin-17A and -17F in Host Defense against Mucoepithelial Bacterial Infection and Allergic Responses

(2009) Harumichi Ishigame et al.   IMMUNITY

Th17 cells at the crossroads of innate and adaptive immunity against infectious diseases at the mucosa

(2009) S A Khader et al.   Mucosal Immunology

Common variants at five new loci associated with early-onset inflammatory bowel disease

(2009) Marcin Imielinski et al.   NATURE GENETICS

Regulatory T Cell-Derived Interleukin-10 Limits Inflammation at Environmental Interfaces

(2008) Yuri P. Rubtsov et al.   IMMUNITY

Differentiation of regulatory Foxp3+ T cells in the thymic cortex

(2008) A. Liston et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulatory T Cells: Mechanisms of Differentiation and Function

(2007) Steven Z. Josefowicz et al.   Annual Review of Immunology