Trimodal single-cell profiling reveals a novel pediatric CD8αα+ T cell subset and broad age-related molecular reprogramming across the T cell compartment

Chronic inflammation and the hallmarks of aging

(2023) Jordan J. Baechle et al.   Molecular Metabolism

BarWare: efficient software tools for barcoded single-cell genomics

(2022) Elliott Swanson et al.   BMC BIOINFORMATICS

Human epigenetic and transcriptional T cell differentiation atlas for identifying functional T cell-specific enhancers

(2022) Josephine R. Giles et al.   IMMUNITY

KIR + CD8 + T cells suppress pathogenic T cells and are active in autoimmune diseases and COVID-19

(2022) Jing Li et al.   SCIENCE

Aging-associated HELIOS deficiency in naive CD4+ T cells alters chromatin remodeling and promotes effector cell responses

(2022) Huimin Zhang et al.   NATURE IMMUNOLOGY

Understanding Early-Life Adaptive Immunity to Guide Interventions for Pediatric Health

(2021) Eleanor C. Semmes et al.   Frontiers in Immunology

ArchR is a scalable software package for integrative single-cell chromatin accessibility analysis

(2021) Jeffrey M. Granja et al.   NATURE GENETICS

Immune dysregulation and autoreactivity correlate with disease severity in SARS-CoV-2-associated multisystem inflammatory syndrome in children

(2021) Anjali Ramaswamy et al.   IMMUNITY

Simultaneous trimodal single-cell measurement of transcripts, epitopes, and chromatin accessibility using TEA-seq

(2021) Elliott Swanson et al.   eLife

Integrated analysis of multimodal single-cell data

(2021) Yuhan Hao et al.   CELL

A cell atlas of human thymic development defines T cell repertoire formation

(2020) Jong-Eun Park et al.   SCIENCE

COVID‐19 is an emergent disease of aging

(2020) Didac Santesmasses et al.   AGING CELL

Comprehensive Profiling of an Aging Immune System Reveals Clonal GZMK+ CD8+ T Cells as Conserved Hallmark of Inflammaging

(2020) Denis A. Mogilenko et al.   IMMUNITY

Fate mapping reveals the age structure of the peripheral T cell compartment

(2019) Arnold Reynaldi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stem Cell Quiescence: Dynamism, Restraint, and Cellular Idling

(2019) Cindy T.J. van Velthoven et al.   Cell Stem Cell

Similar but different: Virtual memory CD 8 T cells as a memory‐like cell population

(2019) Tabinda Hussain et al.   IMMUNOLOGY AND CELL BIOLOGY

Aging promotes reorganization of the CD4 T cell landscape toward extreme regulatory and effector phenotypes

(2019) Yehezqel Elyahu et al.   Science Advances

Fast, sensitive and accurate integration of single-cell data with Harmony

(2019) Ilya Korsunsky et al.   NATURE METHODS

Developmental Origin Governs CD8 + T Cell Fate Decisions during Infection

(2018) Norah L. Smith et al.   CELL

Clustering trees: a visualisation for evaluating clusterings at multiple resolutions

(2018) Luke Zappia et al.   GigaScience

Lack of Sprouty 1 and 2 enhances survival of effector CD8+ T cells and yields more protective memory cells

(2018) Hesham M. Shehata et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activation of miR-21-Regulated Pathways in Immune Aging Selects against Signatures Characteristic of Memory T Cells

(2018) Chulwoo Kim et al.   Cell Reports

Origin and differentiation of human memory CD8 T cells after vaccination

(2017) Rama S. Akondy et al.   NATURE

T memory stem cells in health and disease

(2017) Luca Gattinoni et al.   NATURE MEDICINE

Key Features of Gamma-Delta T-Cell Subsets in Human Diseases and Their Immunotherapeutic Implications

(2017) Myriam Lawand et al.   Frontiers in Immunology

Human memory T cells with a naive phenotype accumulate with aging and respond to persistent viruses

(2016) Vesna Pulko et al.   NATURE IMMUNOLOGY

Virtual memory T cells develop and mediate bystander protective immunity in an IL-15-dependent manner

(2016) Jason T. White et al.   Nature Communications

Long-lasting stem cell–like memory CD8 + T cells with a naïve-like profile upon yellow fever vaccination

(2015) Silvia A. Fuertes Marraco et al.   Science Translational Medicine

CD4+ T Cells from Human Neonates and Infants Are Poised Spontaneously To Run a Nonclassical IL-4 Program

(2014) K. Hebel et al.   JOURNAL OF IMMUNOLOGY

CD8αα Expression Marks Terminally Differentiated Human CD8+ T Cells Expanded in Chronic Viral Infection

(2013) L. J. Walker et al.   Frontiers in Immunology

A human memory T cell subset with stem cell–like properties

(2011) Luca Gattinoni et al.   NATURE MEDICINE