Central role of Tim17 in mitochondrial presequence protein translocation

Structural basis of mitochondrial protein import by the TIM23 complex

(2023) Sue Im Sim et al.   NATURE

PAE viewer: a webserver for the interactive visualization of the predicted aligned error for multimer structure predictions and crosslinks

(2023) Christoph Elfmann et al.   NUCLEIC ACIDS RESEARCH

ColabFold: making protein folding accessible to all

(2022) Milot Mirdita et al.   NATURE METHODS

Highly accurate protein structure prediction with AlphaFold

(2021) John Jumper et al.   NATURE

Translocation of Proteins through a Distorted Lipid Bilayer

(2021) Xudong Wu et al.   TRENDS IN CELL BIOLOGY

Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context

(2021) Marcel Morgenstern et al.   Cell Metabolism

Computed structures of core eukaryotic protein complexes

(2021) Ian R. Humphreys et al.   SCIENCE

Mapping protein interactions in the active TOM-TIM23 supercomplex

(2021) Ridhima Gomkale et al.   Nature Communications

How to get to the other side of the mitochondrial inner membrane – the protein import motor

(2020) Dejana Mokranjac   BIOLOGICAL CHEMISTRY

In Vivo Dissection of the Intrinsically Disordered Receptor Domain of Tim23

(2020) Umut Günsel et al.   JOURNAL OF MOLECULAR BIOLOGY

Structure of the mitochondrial TIM22 complex from yeast

(2020) Yutong Zhang et al.   CELL RESEARCH

Cryo-EM structure of the human mitochondrial translocase TIM22 complex

(2020) Liangbo Qi et al.   CELL RESEARCH

UCSF ChimeraX : Structure visualization for researchers, educators, and developers

(2020) Eric F. Pettersen et al.   PROTEIN SCIENCE

Deletion of Mgr2p Affects the Gating Behavior of the TIM23 Complex

(2019) Oygul Mirzalieva et al.   Frontiers in Physiology

Structure of the mitochondrial import gate reveals distinct preprotein paths

(2019) Yuhei Araiso et al.   NATURE

The Mgr2 subunit of the TIM23 complex regulates membrane insertion of marginal stop‐transfer signals in the mitochondrial inner membrane

(2019) Seoeun Lee et al.   FEBS LETTERS

Role of Tim17 in coupling the import motor to the translocation channel of the mitochondrial presequence translocase

(2017) Keren Demishtein-Zohary et al.   eLife

Cation selectivity of the presequence translocase channel Tim23 is crucial for efficient protein import

(2017) Niels Denkert et al.   eLife

Evolution of the Tim17 protein family

(2016) Vojtěch Žárský et al.   Biology Direct

A disulfide bond in the TIM23 complex is crucial for voltage gating and mitochondrial protein import

(2016) Ajay Ramesh et al.   JOURNAL OF CELL BIOLOGY

Role of Tim17 Transmembrane Regions in Regulating the Architecture of Presequence Translocase and Mitochondrial DNA Stability

(2016) Srujan Kumar Matta et al.   MOLECULAR AND CELLULAR BIOLOGY

The presence of disulfide bonds reveals an evolutionarily conserved mechanism involved in mitochondrial protein translocase assembly

(2016) Lidia Wrobel et al.   Scientific Reports

GxxxG motifs hold the TIM23 complex together

(2015) Keren Demishtein-Zohary et al.   FEBS Journal

Unlocking the presequence import pathway

(2015) Christian Schulz et al.   TRENDS IN CELL BIOLOGY

Mgr2 Functions as Lateral Gatekeeper for Preprotein Sorting in the Mitochondrial Inner Membrane

(2014) Raffaele Ieva et al.   MOLECULAR CELL

Coupling of Mitochondrial Import and Export Translocases by Receptor-Mediated Supercomplex Formation

(2013) Jian Qiu et al.   CELL

Structural changes in the mitochondrial Tim23 channel are coupled to the proton-motive force

(2013) Ketan Malhotra et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Mitochondrial protein import: Common principles and physiological networks

(2012) Jan Dudek et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Accurate multiple sequence alignment of transmembrane proteins with PSI-Coffee

(2012) Jia-Ming Chang et al.   BMC BIOINFORMATICS

Mgr2 promotes coupling of the mitochondrial presequence translocase to partner complexes

(2012) Michael Gebert et al.   JOURNAL OF CELL BIOLOGY

Global Analysis of the Mitochondrial N-Proteome Identifies a Processing Peptidase Critical for Protein Stability

(2009) F.-Nora Vögtle et al.   CELL

Distinct Forms of Mitochondrial TOM-TIM Supercomplexes Define Signal-Dependent States of Preprotein Sorting

(2009) A. Chacinska et al.   MOLECULAR AND CELLULAR BIOLOGY

Fluorescence Mapping of Mitochondrial TIM23 Complex Reveals a Water-Facing, Substrate-Interacting Helix Surface

(2008) Nathan N. Alder et al.   CELL