Aberrant Axonal Arborization of PDF Neurons Induced by Aβ42-Mediated JNK Activation Underlies Sleep Disturbance in an Alzheimer’s Model

Self-reported sleep disturbance is associated with Alzheimer's disease risk in men

(2015) Christian Benedict et al.   Alzheimers & Dementia

TARANIS Functions with Cyclin A and Cdk1 in a Novel Arousal Center to Control Sleep in Drosophila

(2015) Dinis J.S. Afonso et al.   CURRENT BIOLOGY

Sleep Interacts with Aβ to Modulate Intrinsic Neuronal Excitability

(2015) Masashi Tabuchi et al.   CURRENT BIOLOGY

Sleep Restores Behavioral Plasticity to Drosophila Mutants

(2015) Stephane Dissel et al.   CURRENT BIOLOGY

Use of Drosophila in the investigation of sleep disorders

(2015) Nathan C. Donelson et al.   EXPERIMENTAL NEUROLOGY

Modeling the complex pathology of Alzheimer's disease in Drosophila

(2015) Pedro Fernandez-Funez et al.   EXPERIMENTAL NEUROLOGY

Tau-Dependent Kv4.2 Depletion and Dendritic Hyperexcitability in a Mouse Model of Alzheimer's Disease

(2015) Alicia M. Hall et al.   JOURNAL OF NEUROSCIENCE

Three dimensions of the amyloid hypothesis: time, space and 'wingmen'

(2015) Erik S Musiek et al.   NATURE NEUROSCIENCE

β-amyloid disrupts human NREM slow waves and related hippocampus-dependent memory consolidation

(2015) Bryce A Mander et al.   NATURE NEUROSCIENCE

Manipulations of amyloid precursor protein cleavage disrupt the circadian clock in aging Drosophila

(2015) Matthew R. Blake et al.   NEUROBIOLOGY OF DISEASE

Sleep- and wake-dependent changes in neuronal activity and reactivity demonstrated in fly neurons using in vivo calcium imaging

(2015) Daniel Bushey et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Linking Aβ42-Induced Hyperexcitability to Neurodegeneration, Learning and Motor Deficits, and a Shorter Lifespan in an Alzheimer’s Model

(2015) Yong Ping et al.   PLoS Genetics

Identification of a Circadian Output Circuit for Rest:Activity Rhythms in Drosophila

(2014) Daniel J. Cavanaugh et al.   CELL

The central molecular clock is robust in the face of behavioural arrhythmia in a Drosophila model of Alzheimer's disease

(2014) K.-F. Chen et al.   Disease Models & Mechanisms

'The clocks that time us'—circadian rhythms in neurodegenerative disorders

(2014) Aleksandar Videnovic et al.   Nature Reviews Neurology

Nuclear and cytosolic JNK signalling in neurons

(2014) Eleanor T. Coffey   NATURE REVIEWS NEUROSCIENCE

Relationships between the Circadian System and Alzheimer's Disease-Like Symptoms in Drosophila

(2014) Dani M. Long et al.   PLoS One

Orexinergic System Dysregulation, Sleep Impairment, and Cognitive Decline in Alzheimer Disease

(2014) Claudio Liguori et al.   JAMA Neurology

The therapeutics of Alzheimer's disease: Where we stand and where we are heading

(2013) Dennis J. Selkoe   ANNALS OF NEUROLOGY

Neuromodulatory control of sleep in Drosophila melanogaster: integration of competing and complementary behaviors

(2013) Leslie C Griffith   CURRENT OPINION IN NEUROBIOLOGY

Retrograde Bone Morphogenetic Protein Signaling Shapes a Key Circadian Pacemaker Circuit

(2013) E. A. Gorostiza et al.   JOURNAL OF NEUROSCIENCE

Short Neuropeptide F Is a Sleep-Promoting Inhibitory Modulator

(2013) Yuhua Shang et al.   NEURON

A Subset of Cholinergic Mushroom Body Neurons Requires Go Signaling to Regulate Sleep in Drosophila

(2013) Wei Yi et al.   SLEEP

Sleep Quality and Preclinical Alzheimer Disease

(2013) Yo-El S. Ju et al.   JAMA Neurology

Inhibition of JNK/dFOXO pathway and caspases rescues neurological impairments in Drosophila Alzheimer’s disease model

(2012) Yoon Ki Hong et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Epigenetic Regulation of Axonal Growth of Drosophila Pacemaker Cells by Histone Acetyltransferase Tip60 Controls Sleep

(2012) Sheila K. Pirooznia et al.   GENETICS

Pigment-Dispersing Factor Is Involved in Age-Dependent Rhythm Changes in Drosophila melanogaster

(2012) Yujiro Umezaki et al.   JOURNAL OF BIOLOGICAL RHYTHMS

The toxic Aβ oligomer and Alzheimer's disease: an emperor in need of clothes

(2012) Iryna Benilova et al.   NATURE NEUROSCIENCE

Age-dependent alterations in the presynaptic active zone in a Drosophila model of Alzheimer's Disease

(2012) Jian-Kang Huang et al.   NEUROBIOLOGY OF DISEASE

Epidermal growth factor receptor is a preferred target for treating Amyloid- -induced memory loss

(2012) L. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phospho-dependent ubiquitination and degradation of PAR-1 regulates synaptic morphology and tau-mediated Aβ toxicity in Drosophila

(2012) Seongsoo Lee et al.   Nature Communications

The ER stress factor XBP1s prevents amyloid-β neurotoxicity

(2011) Sergio Casas-Tinto et al.   HUMAN MOLECULAR GENETICS

Imaging analysis of clock neurons reveals light buffers the wake-promoting effect of dopamine

(2011) Yuhua Shang et al.   NATURE NEUROSCIENCE

Activation of JNK Signaling Mediates Amyloid-ß-Dependent Cell Death

(2011) Meghana Tare et al.   PLoS One

JNK: A Stress-Activated Protein Kinase Therapeutic Strategies and Involvement in Alzheimer’s and Various Neurodegenerative Abnormalities

(2010) Sidharth Mehan et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Expression of  -Amyloid Induced Age-Dependent Presynaptic and Axonal Changes in Drosophila

(2010) X.-L. Zhao et al.   JOURNAL OF NEUROSCIENCE

Inhibition of c-Jun kinase provides neuroprotection in a model of Alzheimer's disease

(2010) Steven P. Braithwaite et al.   NEUROBIOLOGY OF DISEASE

Identification of a Neural Circuit that Underlies the Effects of Octopamine on Sleep:Wake Behavior

(2010) Amanda Crocker et al.   NEURON

PI3 kinase signaling is involved in A -induced memory loss in Drosophila

(2010) H.-C. Chiang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PDF receptor expression reveals direct interactions between circadian oscillators indrosophila

(2009) Seol Hee Im et al.   JOURNAL OF COMPARATIVE NEUROLOGY

APP binds DR6 to trigger axon pruning and neuron death via distinct caspases

(2009) Anatoly Nikolaev et al.   NATURE

The genetic and molecular regulation of sleep: from fruit flies to humans

(2009) Chiara Cirelli   NATURE REVIEWS NEUROSCIENCE

Amyloid-  Dynamics Are Regulated by Orexin and the Sleep-Wake Cycle

(2009) J.-E. Kang et al.   SCIENCE

DrosophilaModels of Neurodegenerative Diseases

(2008) Bingwei Lu et al.   Annual Review of Pathology-Mechanisms of Disease

Large Ventral Lateral Neurons Modulate Arousal and Sleep in Drosophila

(2008) Vasu Sheeba et al.   CURRENT BIOLOGY

Pigment-Dispersing Factor (PDF) Has Different Effects on Drosophila's Circadian Clocks in the Accessory Medulla and in the Dorsal Brain

(2008) Corinna Wülbeck et al.   JOURNAL OF BIOLOGICAL RHYTHMS

PDF Cells Are a GABA-Responsive Wake-Promoting Component of the Drosophila Sleep Circuit

(2008) Katherine M. Parisky et al.   NEURON

Light-arousal and circadian photoreception circuits intersect at the large PDF cells of the Drosophila brain

(2008) Y. Shang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA