CRISPR-Cas9-modifiedpfmdr1protectsPlasmodium falciparumasexual blood stages and gametocytes against a class of piperazine-containing compounds but potentiates artemisinin-based combination therapy partner drugs

Pharmacokinetic/pharmacodynamic modelling of the antimalarial effect of Actelion-451840 in an induced blood stage malaria study in healthy subjects

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Dihydroartemisinin–piperaquine resistance in Plasmodium falciparum malaria in Cambodia: a multisite prospective cohort study

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Combinatorial Genetic Modeling ofpfcrt-Mediated Drug Resistance Evolution inPlasmodium falciparum

(2016) Stanislaw J. Gabryszewski et al.   MOLECULAR BIOLOGY AND EVOLUTION

Globally prevalent PfMDR1 mutations modulate Plasmodium falciparum susceptibility to artemisinin-based combination therapies

(2016) M. Isabel Veiga et al.   Nature Communications

Evidence of Plasmodium falciparum Malaria Multidrug Resistance to Artemisinin and Piperaquine in Western Cambodia: Dihydroartemisinin-Piperaquine Open-Label Multicenter Clinical Assessment

(2015) Rithea Leang et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Spread of artemisinin-resistant Plasmodium falciparum in Myanmar: a cross-sectional survey of the K13 molecular marker

(2015) Kyaw M Tun et al.   LANCET INFECTIOUS DISEASES

Polymorphisms in Plasmodium falciparum Chloroquine Resistance Transporter and Multidrug Resistance 1 Genes: Parasite Risk Factors That Affect Treatment Outcomes for P. falciparum Malaria After Artemether-Lumefantrine and Artesunate-Amodiaquine

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First-in-Humans Study of the Safety, Tolerability, and Pharmacokinetics of ACT-451840, a New Chemical Entity with Antimalarial Activity

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Role ofPfmdr1inIn VitroPlasmodium falciparum Susceptibility to Chloroquine, Quinine, Monodesethylamodiaquine, Mefloquine, Lumefantrine, and Dihydroartemisinin

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Comparative Impacts Over 5 Years of Artemisinin-Based Combination Therapies on Plasmodium falciparum Polymorphisms That Modulate Drug Sensitivity in Ugandan Children

(2014) Melissa D. Conrad et al.   JOURNAL OF INFECTIOUS DISEASES

Genome editing in the human malaria parasite Plasmodium falciparum using the CRISPR-Cas9 system

(2014) Mehdi Ghorbal et al.   NATURE BIOTECHNOLOGY

Efficient CRISPR-Cas9–mediated genome editing in Plasmodium falciparum

(2014) Jeffrey C Wagner et al.   NATURE METHODS

Spread of Artemisinin Resistance in Plasmodium falciparum Malaria

(2014) Elizabeth A. Ashley et al.   NEW ENGLAND JOURNAL OF MEDICINE

Dihydroartemisinin–Piperaquine Failure in Cambodia

(2014) David L. Saunders et al.   NEW ENGLAND JOURNAL OF MEDICINE

K13-propeller mutations confer artemisinin resistance in Plasmodium falciparum clinical isolates

(2014) J. Straimer et al.   SCIENCE

Efficient Editing of Malaria Parasite Genome Using the CRISPR/Cas9 System

(2014) C. Zhang et al.   mBio

A Plasmodium falciparum screening assay for anti-gametocyte drugs based on parasite lactate dehydrogenase detection

(2013) Sarah D'Alessandro et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

UV-triggered Affinity Capture Identifies Interactions between thePlasmodium falciparumMultidrug Resistance Protein 1 (PfMDR1) and Antimalarial Agents in Live Parasitized Cells

(2013) Ralf Brunner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A molecular marker of artemisinin-resistant Plasmodium falciparum malaria

(2013) Frédéric Ariey et al.   NATURE

Quinine localizes to a non-acidic compartment within the food vacuole of the malaria parasite Plasmodium falciparum

(2012) Elaine B Bohórquez et al.   MALARIA JOURNAL

Piperaquine Resistance Is Associated with a Copy Number Variation on Chromosome 5 in Drug-PressuredPlasmodium falciparumParasites

(2011) Richard T. Eastman et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Directional gene expression and antisense transcripts in sexual and asexual stages of Plasmodium falciparum

(2011) María J López-Barragán et al.   BMC GENOMICS

Epidemiology and Infectivity of Plasmodium falciparum and Plasmodium vivax Gametocytes in Relation to Malaria Control and Elimination

(2011) T. Bousema et al.   CLINICAL MICROBIOLOGY REVIEWS

Identifying apicoplast-targeting antimalarials using high-throughput compatible approaches

(2011) Eric H. Ekland et al.   FASEB JOURNAL

Soft X-ray microscopy analysis of cell volume and hemoglobin content in erythrocytes infected with asexual and sexual stages of Plasmodium falciparum

(2011) Eric Hanssen et al.   JOURNAL OF STRUCTURAL BIOLOGY

Novel Polymorphisms in Plasmodium falciparum ABC Transporter Genes Are Associated with Major ACT Antimalarial Drug Resistance

(2011) Maria Isabel Veiga et al.   PLoS One

Quantitative assessment of Plasmodium falciparum sexual development reveals potent transmission-blocking activity by methylene blue

(2011) S. H. Adjalley et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Association Between the pfmdr1 Gene and In Vitro Artemether and Lumefantrine Sensitivity in Thai Isolates of Plasmodium falciparum

(2010) Mathirut Mungthin et al.   AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

Protein Export Marks the Early Phase of Gametocytogenesis of the Human Malaria ParasitePlasmodium falciparum

(2010) Francesco Silvestrini et al.   MOLECULAR & CELLULAR PROTEOMICS

Artemisinin Resistance inPlasmodium falciparumMalaria

(2009) Arjen M. Dondorp et al.   NEW ENGLAND JOURNAL OF MEDICINE

Use of high-density tiling microarrays to identify mutations globally and elucidate mechanisms of drug resistance in Plasmodium falciparum

(2009) Neekesh V Dharia et al.   GENOME BIOLOGY