Article
Medicine, Research & Experimental
Ni Zeng, Yu-Qing Huang, Yu-Min Yan, Zhi-Qin Hu, Zhuo Zhang, Jia-Xin Feng, Ji-Shen Guo, Jie-Ning Zhu, Yong-Heng Fu, Xi-Pei Wang, Meng-Zhen Zhang, Jin-Zhu Duan, Xi-Long Zheng, Jin-Dong Xu, Zhi-Xin Shan
Summary: miR-199a-5p and -3p are co-upregulated in the myocardium during cardiac remodeling and can aggravate cardiac hypertrophy and fibrosis by targeting different genes. Inhibition of miR-199a-5p and -3p may present a new therapeutic strategy for cardiac remodeling.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2021)
Article
Multidisciplinary Sciences
Omayma O. Abdelaleem, Shereen Rashad Mohammed, Hassan S. El Sayed, Sherin Khamis Hussein, Doaa Y. Ali, Mostafa Y. Abdelwahed, Sylvana N. Gaber, Nada F. Hemeda, Rehab G. Abd El-Hmid
Summary: This study found that serum levels of miR-34a-5p and miR-199a-3p were significantly reduced in neonates with sepsis, and they were associated with the severity of sepsis.
Article
Biotechnology & Applied Microbiology
Wenjing Wu, Keke Liu, Zhongyu You, Jin Zhang
Summary: Using BGISEQ-500 sequencing technology, this study found that miR-196b-3p expression was 32-fold higher and miR-450b-3p expression was 8-fold lower in intramuscular adipocytes (IM) compared to subcutaneous adipocytes (SC) in pigs. Functional studies revealed that miR-196b-3p inhibits adipogenesis by targeting CD47 via the AMPK signaling pathway, while miR-450b-3p promotes adipogenesis by targeting SIRT1 via the Wnt/β-catenin signaling pathway.
Article
Pharmacology & Pharmacy
Li Yan, Xu Xie, Bing-Xuan Niu, Mei-Ting Wu, Wei-Qiang Tong, Shuang-Yi He, Chu-Yi Huang, Wei-Chen Zhao, Ge Li, Nian-Sheng Li, Jun-Lin Jiang
Summary: Endothelial cell dysfunction is a common complication of diabetes, and this study identified DDR1 as a key player in endothelial cell senescence under diabetic conditions. The miR-199a-3p/DDR1/p53/p21 signaling pathway was found to be involved in regulating endothelial senescence induced by high glucose, suggesting DDR1 as a potential therapeutic target for inhibiting endothelial senescence in diabetic patients.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Moamen Masalha, Tal Meningher, Adi Mizrahi, Aviv Barzilai, Hilla Tabibian-Keissar, Devorah Gur-Wahnon, Iddo Z. Ben-Dov, Joshua Kapenhas, Jasmine Jacob-Hirsch, Raya Leibowitz, Yechezkel Sidi, Dror Avni
Summary: Cutaneous squamous cell carcinoma (CSCC) is a skin cancer that evolves from normal epidermis and is characterized by the disruption of cell-cell contacts and acquisition of a mesenchymal motile phenotype. The decreased expression of miR-199a-3p plays a crucial role in this process by targeting RAP2B and inhibiting the epithelial-to-mesenchymal transition (EMT). Inhibitors of RAP2B or FAK may be potential therapeutic agents for CSCC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Health Care Sciences & Services
Paola Fuso, Mariantonietta Di Salvatore, Concetta Santonocito, Donatella Guarino, Chiara Autilio, Antonino Mule, Damiano Arciuolo, Antonina Rinninella, Flavio Mignone, Matteo Ramundo, Brunella Di Stefano, Armando Orlandi, Ettore Capoluongo, Nicola Nicolotti, Gianluca Franceschini, Alejandro Martin Sanchez, Giampaolo Tortora, Giovanni Scambia, Carlo Barone, Alessandra Cassano
Summary: The up-regulation of miRNAs let-7a-5p, mirR-100-5p, miR-101-3p, and miR-199a-3p is associated with better event-free survival and overall survival in breast cancer patients, regardless of breast cancer subtypes.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Xiaodong Gu, Ruiqiang Weng, Jingyuan Hou, Sudong Liu
Summary: In this study, miR-199a-3p was found to suppress endothelial inflammation and adhesion by targeting the mTOR signaling pathway and increasing autophagy. This miRNA plays an important role in the early stages of cardiovascular disease.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Elisa Callegari, Paola Guerriero, Cristian Bassi, Lucilla D. ' Abundo, Antonio Frassoldati, Edi Simoni, Laura Astol, Enrico Maria Silini, Silvia Sabbioni, Massimo Negrini
Summary: The combination of palbociclib with MK-2206 showed great efficacy but high toxicity, while the combination with miR-199a-3p mimics not only induced tumor regression but was also well tolerated.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2022)
Article
Nutrition & Dietetics
Noura B. Younes, Omnia Ahmed Mohamed, Nasser M. Rizk
Summary: This study demonstrates that DHA has the potential to mitigate obesity by reducing the secretion of inflammatory adipokines, oxidative stress, lipolysis, and apoptosis in adipocytes exposed to low O-2 tension-induced hypoxia.
Article
Biochemistry & Molecular Biology
Xiaomin Liu, Xianyi Wang, Binshu Chai, Zong Wu, Zhitao Gu, Heng Zou, Hui Zhang, Yanli li, Qiangling Sun, Wentao Fang, Zhongliang Ma
Summary: This study found that miR-199a-3p/5p is down-regulated in non-small cell lung cancer (NSCLC), and overexpression of miR-199a-3p/5p can inhibit cell proliferation, migration, and promote apoptosis. Rheb is identified as a common target of miR-199a-3p and miR-199a-5p, participating in the regulation of the mTOR signaling pathway. Additionally, miR-199a significantly inhibits tumor growth and metastasis in NSCLC and enhances the sensitivity of gefitinib in EGFR-T790M mutation. MiR-199a-3p/5p has the potential to serve as an early diagnostic marker or therapeutic target for NSCLC.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Biotechnology & Applied Microbiology
Shuaipeng Zhu, Binbin Zhang, Tingqi Zhu, Dongxue Wang, Cong Liu, Yixuan Liu, Yuehua He, Wenjie Liang, Wenting Li, Ruili Han, Donghua Li, Fengbin Yan, Yadong Tian, Guoxi Li, Xiangtao Kang, Zhuanjian Li, Ruirui Jiang, Guirong Sun
Summary: miR-128-3p inhibits intramuscular adipocyte differentiation in chickens by downregulating FDPS. The study provides a theoretical basis for the study of lipid metabolism and identifies a potential target for molecular breeding to improve meat quality.
Article
Oncology
Li Li, Lei Wang, Jia-li Yang, Hui-Ju Wang, Yuan-yu Wang
Summary: Proximal gastrectomy is commonly recommended for early upper gastric cancer and Siewert II gastroesophageal junction cancer less than 4 cm. This procedure may disrupt the anatomical structure of the gastroesophageal junction and result in loss of anti-reflux function. With the development of various anti-reflux reconstructions, some gastric functions can be preserved, preventing the occurrence of severe reflux esophagitis after proximal gastrectomy. This article summarizes the indications, advantages, and disadvantages of various classic and latest improved reconstruction methods, including esophageal and residual stomach anastomosis, tubular gastroesophageal anastomosis, muscle flap anastomosis, jejunal interposition, and double-tract reconstruction.
Article
Biochemistry & Molecular Biology
Catherine Jane Messner, Saskia Schmidt, Dilek Ozkul, Carine Gaiser, Luigi Terracciano, Stephan Krahenbuhl, Laura Suter-Dick
Summary: Liver fibrosis is characterized by the accumulation of extracellular matrix, and miRNAs can serve as biomarkers for identifying this condition. In this study, miR-199a-5p, miR-214-3p, miRNA-125a-5p, and miR-99b-5p are identified as potential biomarkers associated with a fibrotic phenotype, with miR-199a-5p also being implicated in HSC activation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Bin Zhao, Cong Huang, Jie Pan, Hao Hu, Xiaojuan Liu, Kaoyuan Zhang, Fenli Zhou, Xin Shi, Jun Wu, Bo Yu, Xiaofan Chen, Wei Zhang
Summary: Recent evidence shows that circRNAs, particularly circPLIN2, play important regulatory roles in the development and progression of clear cell renal cell carcinoma (ccRCC) by increasing mRNA stability and competitively binding specific miRNA.
CELL DEATH & DISEASE
(2022)
Article
Oncology
Sofia Elena Tesolato, Daniel Gonzalez-Gamo, Ana Barabash, Paula Claver, Sofia Cristina de la Serna, Inmaculada Dominguez-Serrano, Jana Dziakova, Carmen de Juan, Antonio Jose Torres, Pilar Iniesta
Summary: This study aims to analyze and correlate the expression levels of four miRNAs associated with cancer and obesity in colorectal cancer (CRC) patients and a control group. The results indicate the significance of hsa-miR-143-3p and hsa-miR-181a-5p in the clinical management of CRC.