Article
Immunology
Junquan Song, Rongyuan Wei, Shiying Huo, Jianpeng Gao, Xiaowen Liu
Summary: Through the analysis of differentially expressed genes between metastatic gastric cancer and primary gastric cancer, a metastasis-related epithelial-mesenchymal transition signature (MEMTS) was constructed. High MEMTS indicates a poor prognosis in patients with gastric cancer, and patients with low MEMTS may benefit more from adjuvant chemoradiotherapy. MEMTS reliably predicts the response to immunotherapy in gastric cancer and is significantly associated with cancer-associated fibroblasts and stromal score in the tumor microenvironment.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, Research & Experimental
Tong Zhu, Xiaoming Zou, Chunfa Yang, Liangliang Li, Bing Wang, Rong Li, Hongxuan Li, Zhangxuan Xu, Di Huang, Qingyun Wu
Summary: Neutrophil extracellular traps (NETs) in gastric cancer (GC) are associated with tumor progression, metastasis risk, and tumor microenvironment. The study found that NETs formation is affected by the tumor microenvironment and may exacerbate GC progression through promoting epithelial-mesenchymal transition (EMT). Hence, targeting NETs may be therapeutically beneficial in GC treatment.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2021)
Article
Biotechnology & Applied Microbiology
Yi Sun, Rui Du, Yulong Shang, Changhao Liu, Linhua Zheng, Ruiqing Sun, Yuanyong Wang, Guofang Lu
Summary: This study reveals the significant role of ARHGAP35 in gastric cancer, specifically in regulating cell morphology and motility through cytoskeletal reorganization and EMT, respectively. Targeting the ARHGAP35/RhoA/E-cadherin pathway could be a potential therapeutic approach for treating gastric cancer.
Article
Cell Biology
Dan Dong, Lei Na, Kailing Zhou, Zhuo Wang, Yu Sun, Qianqian Zheng, Jian Gao, Chenghai Zhao, Wei Wang
Summary: The research revealed that FZD5 prevents EMT in gastric cancer and is associated with longer survival. ELF3 acts as a downstream effector of FZD5, repressing ZEB1 expression and guarding against EMT.
CELL COMMUNICATION AND SIGNALING
(2021)
Article
Biotechnology & Applied Microbiology
Cheng Zhang, Yu Liang, Chun-Dong Zhang, Jun-Peng Pei, Kun-Zhe Wu, Yong-Zhi Li, Dong-Qiu Dai
Summary: LINC01235 is significantly over-expressed in gastric cancer cells and tissues, and its high expression is positively correlated with poor prognosis. It can promote cancer cell metastasis through the EMT pathway.
Review
Oncology
Xiaobo Zheng, Fuzhen Dai, Lei Feng, Hong Zou, Li Feng, Mingqing Xu
Summary: The interplay between epithelial-mesenchymal plasticity and cancer stem cells plays a crucial role in cancer progression, affecting the aggressiveness of tumor cells and their response to treatment. Understanding the dynamic nature of EMT as a hybrid state rather than a binary model is important for unraveling the complexities of cancer biology and developing targeted therapeutic interventions.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Fatima Junaid, Goran Tomic, Richard Kemp, Doug J. Winton
Summary: Using human colon cancer DLD-1 cells, the study engineered a cell line with inducible Snail expression and found that partial EMT induced by Snail overexpression in DLD-1 cells leads to chemoresistance, increased tumor growth, and decreased apoptosis, highlighting the importance of bioavailable Snail in determining the phenotypic outcome.
Review
Oncology
Barbora Kvokackova, Jan Remsik, Mohit Kumar Jolly, Karel Soucek
Summary: Epithelial-mesenchymal transition (EMT) and mesenchymal-epithelial transition (MET) play critical roles in the development of TNBC, shaping aggressive and heterogeneous biological features, but may also contribute to the progression of metastatic disease.
Article
Medicine, General & Internal
Jibin Yao, Yongbin Zhang, Yu Xia, Chenglou Zhu, Xiaoxiong Wen, Tianxiang Liu, Mingxu Da
Summary: Bioinformatics analysis revealed the correlation between PRRX1 gene and lymph node metastasis in gastric cancer. Experimental results showed significantly elevated expression of PRRX1 in gastric cancer tissues, suggesting its role in promoting lymph node metastasis through regulating EMT. Therefore, PRRX1 could potentially serve as a novel biological indicator for predicting or preventing lymph node metastasis in gastric cancer.
Article
Oncology
Chuan-Hong Li, Zhang-Ming Chen, Pei-Feng Chen, Lei Meng, Wan-Nian Sui, Song-Cheng Ying, A-Man Xu, Wen-Xiu Han
Summary: This study suggests that IL-34 expression is increased in gastric cancer tissues and cell lines. IL-34 affects the proliferation, clone formation, migration, and invasion of gastric cancer cells by regulating the expression of EMT-related proteins. Therefore, interference with IL-34 may represent a novel strategy for the diagnosis and targeted therapy of gastric cancer.
WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Joanna Kozak, Alicja Forma, Marcin Czeczelewski, Pawel Kozyra, Elzbieta Sitarz, Elzbieta Radzikowska-Buchner, Monika Sitarz, Jacek Baj
Summary: Epithelial-mesenchymal transition (EMT) is a key process in the development of gastric cancer, affecting patient outcomes. There is an urgent need for research on pharmacological agents targeting EMT to prevent progression and potential metastasis of gastric cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Ningxin Dong, Xiaolong Ma, Jing Shen, Yunlu Zheng, Guiyuan Li, Shaoqiang Zheng, Xiaoyi Huang
Summary: A four-gene prognostic model was constructed to stratify GC patients into different prognosis score groups, with high-prognosis score groups showing significantly poorer survival rates. MYL9 was found to be associated with migration and metastasis of GC cells.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Anda Huna, Beatrice Nawrocki-Raby, Teresita Padilla-Benavides, Julie Gavard, Sylvie Coscoy, David Bernard, Mathieu Boissan
Summary: NME1, not NME2, acts specifically to inhibit EMT and prevent the earliest stages of metastasis. Loss of NME1 leads to a hybrid phenotype associated with higher metastatic potential, while overexpression of NME1 results in a more epithelial phenotype. Additionally, NME1 inhibits key intracellular signaling pathways involved in inducing EMT, such as AKT and MAPK pathways, and affects the distribution and cell-cell adhesion of E-cadherin.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Dong Ik Cha, Jeeyun Lee, Woo Kyoung Jeong, Seung Tae Kim, Jae-Hun Kim, Jung Yong Hong, Won Ki Kang, Kyoung-Mee Kim, Seon Woo Kim, DongilW Choi
Summary: The study developed a predictive model for the epithelial-to-mesenchymal transition (EMT) subtype of gastric cancer using computed tomography (CT) images and known clinicopathologic variables. A nomogram was constructed for individualized estimation of EMT subtype, providing a useful screening tool for personalized medicine.
EUROPEAN RADIOLOGY
(2022)
Article
Oncology
Fu-Chun Huo, Wen-Tao Zhu, Xu Liu, Yun Zhou, Lan-Sheng Zhang, Jie Mou
Summary: EGFL6 is overexpressed in gastric cancer and associated with poor prognostic factors. It enhances cancer cell proliferation, migration, and invasion through regulating multiple signaling pathways. EGFL6 may serve as a potential therapeutic target for gastric cancer.
INVESTIGATIONAL NEW DRUGS
(2021)