期刊
MOLECULAR MEDICINE REPORTS
卷 14, 期 6, 页码 4931-4941出版社
SPANDIDOS PUBL LTD
DOI: 10.3892/mmr.2016.5867
关键词
FOXO proteins; posttranslational modifications; activity; sites
The Forkhead box O (FOXO) protein family is predominantly involved in apoptosis, oxidative stress, DNA damage/repair, tumor angiogenesis, glycometabolism, regulating life span and other important biological processes. Its activity is affected by a variety of posttranslational modifications (PTMs), including phosphorylation, acetylation, ubiquitination, methylation and glycosylation. When cells are subjected to different environments, the corresponding PTMs act on the FOXO protein family, to change transcriptional activity or subcellular localization, and the expression of downstream target genes, will ultimately affect the biological behavior of the cells. In this review, we will discuss the biological characteristics of FOXO protein PTMs.
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