Article
Biochemistry & Molecular Biology
Zhen Li, Yanhong Geng, Qingke Wu, Xin Jin, Vidya Devanathadesikan Seshadri, Hao Liu
Summary: The present study aimed to explore the beneficial effects of triptonide in inflammation, asthma, and nociceptive conditions. Triptonide exhibited anti-inflammation properties and was effective in reducing asthma symptoms. It also showed significant antinociceptive effects in mice. The study concluded that triptonide could be a promising compound for the management of asthma and related diseases.
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
(2023)
Article
Plant Sciences
Mariam Sharif, Irfan Anjum, Arham Shabbir, Muhammad Naveed Mushtaq
Summary: The study found that A. lanata herbal extract has immunomodulatory and anti-inflammatory effects on allergic asthmatic mice, reducing the number of inflammatory cells, lowering the level of inflammatory mediators, and increasing the expression levels of aquaporin.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Teodora-Irina Adam-Bonci, Eduard-Alexandru Bonci, Alina-Elena Parvu, Andrei-Ioan Herdean, Augustin Mot, Marian Taulescu, Andrei Ungur, Raluca-Maria Pop, Corina Bocsan, Alexandru Irimie
Summary: The study showed that oral vitamin D supplementation can reduce oxidative forces and increase antioxidant capacity, while also exhibiting anti-inflammatory effects to protect against acute airway inflammation related to oxidative stress processes induced by ovalbumin.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, Research & Experimental
So-Won Pak, A. Yeong Lee, Yun-Soo Seo, Se-Jin Lee, Woong-Il Kim, Dong-Ho Shin, Jong-Choon Kim, Joong-Sun Kim, Je-Oh Lim, In-Sik Shin
Summary: The extract of Phlomis umbrosa showed significant anti-inflammatory and anti-allergic effects in an asthma model, achieved by suppressing specific signaling pathways.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Pharmacology & Pharmacy
Jiajing Hong, Fuchun Wang, Dongyu Yang, Junming Kan
Summary: Fusarubin has anti-asthmatic effects in an ovalbumin-induced rat asthma model. It reduces airway hyperresponsiveness, inflammatory cell levels, and eosinophil levels, while also lowering pro-inflammatory cytokine levels.
TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH
(2022)
Article
Food Science & Technology
Yao Lu, Yutao Zhou, Yingying Lin, Wusun Li, Shousheng Tian, Xianghui Hao, Huiyuan Guo
Summary: The study found that oral administration of donkey milk powder can improve asthma symptoms, alleviate airway injury and fibrosis, reduce mucin accumulation, goblet cell hyperplasia, and airway inflammation.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Plant Sciences
Xin Han, Shaoqi Hu, Qiao Yang, Xianan Sang, Dongxin Tang, Gang Cao
Summary: This study found that TGP and PF can improve lung injury in a mouse model of asthma by inhibiting inflammation, regulating immune response, reducing oxidative stress and inhibiting autophagy.
Article
Biochemistry & Molecular Biology
Jeng-Chang Chen, Cheng-Chi Chan, Nai-Chun Ting, Ming-Ling Kuo
Summary: The study found that neonatal exposure to allergens can trigger asthma-related immune responses and exacerbate asthma symptoms in adulthood. Gender differences play a significant role in asthma development, with females being more susceptible to asthma-related stimuli.
Article
Respiratory System
Nguyen Phuong Khanh Le, Amanda Florentina do Nascimento, David Schneberger, Chi Cuong Quach, Xiaobei Zhang, Gurpreet K. Aulakh, Wojciech Dawicki, Lixin Liu, John R. Gordon, Baljit Singh
Summary: This study found that deficiency of LSP1 reduces airway hyper-responsiveness and lung inflammation in a mouse model of asthma. The levels of LSP1 were increased in the lungs of asthmatic mice and were associated with leukocyte recruitment. These findings suggest that LSP1 is involved in the pathogenesis of asthma.
RESPIRATORY RESEARCH
(2022)
Article
Plant Sciences
Qiong Wang, Yubao Cui, Xufeng Wu, Junfang Wang
Summary: Evodiamine from Evodia rutaecarpa possesses strong anti-inflammatory, immunomodulatory, and antibacterial properties. In this study, evodiamine demonstrated protective effects in asthma by reducing levels of inflammatory cytokines, IgE, and IFN-gamma, as well as inhibiting airway inflammation and remodelling in the lung tissue. Lower levels of TLR-4, MyD88, NF-kappa B, and HMGB1 mRNA were observed in lung tissue of evodiamine-treated rats compared to asthma rats.
PHARMACEUTICAL BIOLOGY
(2021)
Article
Immunology
Nandhine Rajasekar, Ayyanar Sivanantham, Amrita Kar, Sramana Mukhopadhyay, Santanu Kar Mahapatra, Sudhakar Gandhi Paramasivam, Subbiah Rajasekaran
Summary: Tannic acid was shown to effectively reduce airway hyperresponsiveness, alleviate inflammatory response, and inhibit airway remodeling in asthmatic mice challenged with ovalbumin. This study suggests that TA may be a potential therapeutic option for allergic asthma in clinical settings.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Respiratory System
Jingru Wang, Shengnan Gao, Jingyuan Zhang, Chunxiao Li, Hongwen Li, Jiangtao Lin
Summary: IL-22 can play a protective role in an OVA-induced asthma model by reducing airway hyperresponsiveness and inhibiting inflammatory cell infiltration around bronchi and their concomitant vessels, which may be associated with the expression of its heterodimer receptors.
BMC PULMONARY MEDICINE
(2021)
Article
Respiratory System
Yilan Song, Jingzhi Jiang, Qiaoyun Bai, Siqi Liu, Yalin Zhang, Chang Xu, Hongmei Piao, Liangchang Li, Guanghai Yan
Summary: This study explored the gene expression profiles in lung tissues from mice with ovalbumin (OVA)-induced asthma using microarray and bioinformatics analysis. The results showed that there were differentially expressed lncRNAs and mRNAs in lung tissues between control and asthmatic mice. By screening and analysis, core mRNAs and their related lncRNAs associated with asthma were identified.
BMC PULMONARY MEDICINE
(2023)
Article
Cell Biology
Saeideh Saadat, Mohammad Hossein Boskabady
Summary: The study reveals that rosuvastatin treatment can reduce inflammation response and oxidative stress levels in asthma patients, effectively improving asthma symptoms.
Article
Chemistry, Medicinal
Islam Ahmed Abdelmawgood, Noha Ahmed Mahana, Abeer Mahmoud Badr, Ayman Saber Mohamed, Abdeljalil Mohamed Al Shawoush, Tarek Atia, Amir Elhadi Abdelrazak, Hader I. Sakr
Summary: This research aimed to investigate the effects of Ech on asthma-induced inflammation, oxidative stress, and histopathological alterations in the spleen, liver, and kidney. The results demonstrated that Ech has antioxidant and anti-inflammatory activities, and it can lower the serum levels of IgE, IL-4, and IL-1β, attenuate oxidative stress, and ameliorate histopathological abnormalities.