Changes in the Activities and Contents of Individual Forms of Proteasomes in Samples of the Cerebral Cortex during Pathology Development in 5xFAD Mice

Neuroinflammation, not amyloid-β deposition, associated with brain network dysfunction in AD

(2023) Sarah Lemprière   Nature Reviews Neurology

Ubiquitin signalling in neurodegeneration: mechanisms and therapeutic opportunities

(2021) Marlene F. Schmidt et al.   CELL DEATH AND DIFFERENTIATION

Macrocyclic Immunoproteasome Inhibitors as a Potential Therapy for Alzheimer’s Disease

(2021) Min Jae Lee et al.   JOURNAL OF MEDICINAL CHEMISTRY

Deficient immunoproteasome assembly drives gain of α-synuclein pathology in Parkinson's disease

(2021) Mingxia Bi et al.   Redox Biology

Proteasome Subunits Involved in Neurodegenerative Diseases

(2020) Iván Fernández-Cruz et al.   ARCHIVES OF MEDICAL RESEARCH

Mechanisms of Pathogenic Tau and Aβ Protein Spreading in Alzheimer’s Disease

(2020) Paolo d‘Errico et al.   Frontiers in Aging Neuroscience

A dual inhibitor of the proteasome catalytic subunits LMP2 and Y attenuates disease progression in mouse models of Alzheimer’s disease

(2019) In Jun Yeo et al.   Scientific Reports

Perturbations of Ubiquitin-Proteasome-Mediated Proteolysis in Aging and Alzheimer’s Disease

(2019) Ashok N. Hegde et al.   Frontiers in Aging Neuroscience

In Situ Structure of Neuronal C9orf72 Poly-GA Aggregates Reveals Proteasome Recruitment

(2018) Qiang Guo et al.   CELL

A common mechanism of proteasome impairment by neurodegenerative disease-associated oligomers

(2018) Tiffany A. Thibaudeau et al.   Nature Communications

Amyloid-β Toxicity and Tau Hyperphosphorylation are Linked Via RCAN1 in Alzheimer's Disease

(2018) Ana Lloret et al.   JOURNAL OF ALZHEIMERS DISEASE

Oxidative Stress, Synaptic Dysfunction, and Alzheimer’s Disease

(2017) Eric Tönnies et al.   JOURNAL OF ALZHEIMERS DISEASE

Detection of active proteasome structures in brain extracts: proteasome features of August rat brain with violations in monoamine metabolism

(2017) Pavel A. Erokhov et al.   Oncotarget

The Decrease of Uch-L1 Activity Is a Common Mechanism Responsible for Aβ 42 Accumulation in Alzheimer’s and Vascular Disease

(2017) Michela Guglielmotto et al.   Frontiers in Aging Neuroscience

Immunoproteasome deficiency alters microglial cytokine response and improves cognitive deficits in Alzheimer’s disease-like APPPS1 mice

(2017) Lisa K. Wagner et al.   Acta Neuropathologica Communications

The Proteasome and Oxidative Stress in Alzheimer's Disease

(2016) Vicent Bonet-Costa et al.   ANTIOXIDANTS & REDOX SIGNALING

Amyloid-β Increases Activity of Proteasomes Capped with 19S and 11S Regulators

(2016) Alexey V. Morozov et al.   JOURNAL OF ALZHEIMERS DISEASE

Biological significance of co- and post-translational modifications of the yeast 26S proteasome

(2016) Hisashi Hirano et al.   Journal of Proteomics

Ubp6 deubiquitinase controls conformational dynamics and substrate degradation of the 26S proteasome

(2015) Charlene Bashore et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Ubp6 deubiquitinase controls conformational dynamics and substrate degradation of the 26S proteasome

(2015) Charlene Bashore et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The ubiquitin-proteasome system in neurodegenerative diseases: precipitating factor, yet part of the solution

(2014) Nico P. Dantuma et al.   Frontiers in Molecular Neuroscience

Reactive glia show increased immunoproteasome activity in Alzheimer’s disease

(2013) Marie Orre et al.   BRAIN

The Proteasome Function Reporter GFPu Accumulates in Young Brains of the APPswe/PS1dE9 Alzheimer’s Disease Mouse Model

(2013) Yanying Liu et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Amyloid Generation and Dysfunctional Immunoproteasome Activation with Disease Progression in Animal Model of Familial Alzheimer's Disease

(2011) Ester Aso et al.   BRAIN PATHOLOGY

Amyloid-β Peptide Is a Substrate of the Human 20S Proteasome

(2010) Xiaobei Zhao et al.   ACS Chemical Neuroscience

The immunoproteasome, the 20S proteasome and the PA28αβ proteasome regulator are oxidative-stress-adaptive proteolytic complexes

(2010) Andrew M. Pickering et al.   BIOCHEMICAL JOURNAL

Loss of HRD1-Mediated Protein Degradation Causes Amyloid Precursor Protein Accumulation and Amyloid-  Generation

(2010) M. Kaneko et al.   JOURNAL OF NEUROSCIENCE

Motor deficits, neuron loss, and reduced anxiety coinciding with axonal degeneration and intraneuronal Aβ aggregation in the 5XFAD mouse model of Alzheimer's disease

(2010) Sadim Jawhar et al.   NEUROBIOLOGY OF AGING

Variably modulated gating of the 26S proteasome by ATP and polyubiquitin

(2009) Xiaohua Li et al.   BIOCHEMICAL JOURNAL

Ubiquitinated Proteins Activate the Proteasome by Binding to Usp14/Ubp6, which Causes 20S Gate Opening

(2009) Andreas Peth et al.   MOLECULAR CELL

Polyubiquitin substrates allosterically activate their own degradation by the 26S proteasome

(2009) Dawadschargal Bech-Otschir et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

E2-25K/Hip-2 regulates caspase-12 in ER stress–mediated Aβ neurotoxicity

(2008) Sungmin Song et al.   JOURNAL OF CELL BIOLOGY

Aβ inhibits the proteasome and enhances amyloid and tau accumulation

(2007) Bertrand P. Tseng et al.   NEUROBIOLOGY OF AGING