Review
Pharmacology & Pharmacy
S. Korake, A. Shaikh, R. Salve, K. R. Gajbhiye, V Gajbhiye, A. Pawar
Summary: The family of Boltorn™ H40 dendrimers, as an imperative subclass of hyperbranched biodegradable polymers, has unique chemical, physical, and biodegradable properties that make it ideal for advanced drug delivery systems, especially in cancer therapy. Its three-dimensional dendrimeric nanoarchitecture, low toxicity, and natural biodegradation are key advantages for targeted cargo delivery carriers.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Review
Engineering, Multidisciplinary
Wei Yin, Feng Pan, Junjie Zhu, Junwu Xu, Diego Gonzalez-Rivas, Meinoshin Okumura, Zhiyong Tang, Yang Yang
Summary: Lung cancer, a leading cause of cancer-related deaths globally, has prompted the development of nanotechnology and nanomedicine approaches to improve early diagnosis and individualized treatment options. While successful in research, challenges remain in the clinical translation of nanomedicine due to limited understanding of interactions with biology and manufacturing challenges.
Review
Pharmacology & Pharmacy
Jieqiong You, Ying Wang, Haifeng Chen, Fang Jin
Summary: As an essential mediator of inflammation and innate immunity, RIPK2 plays a significant role in transducing signaling downstream of NOD-like receptors, leading to the activation of pro-inflammatory cytokines. Its involvement in tumorigenesis and malignant progression suggests its potential as an anti-tumor drug target. This article evaluates the feasibility of targeting RIPK2 and summarizes the research progress of RIPK2 inhibitors. Furthermore, it analyzes the possibility of applying small molecule RIPK2 inhibitors in anti-tumor therapy.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Chemistry, Medicinal
Elena F. Shevtsova, Andrey A. Maltsev, Darya V. Vinogradova, Pavel N. Shevtsov, Sergey O. Bachurin
Summary: Mitochondria-targeting drugs can be categorized into those compensating for energy deficit and inhibiting MPT, and neuroprotectors increasing mitochondrial resistance. However, monotherapy for patients with severe symptoms may not be effective, it is optimal to combine multiple targets for better outcomes.
MEDICINAL RESEARCH REVIEWS
(2021)
Article
Psychology, Multidisciplinary
Bin Yin, Ya-Xin Wang, Cheng-Yang Fei, Ke Jiang
Summary: Personality disorders are often treated through face-to-face sessions or digital mental health services. Schema therapy is a standout therapy that not only targets the symptoms of personality disorders, but also focuses on addressing their underlying causes by healing early maladaptive schemas. This therapy is particularly effective at soothing emotional disturbances before implementing cognitive restructuring, leading to long-term efficacy. However, according to Piaget's genetic epistemology, the formation of adaptive behavioral schemas can only occur through interaction with the real world and feedback from the environment. Therefore, to reshape a patient's schema modes and restore their emotional regulation capabilities, it may be necessary to reconstruct the patient's surroundings. Metaverse, the successor to the Internet with a sense of full presence, can be a powerful tool for this purpose, allowing therapists to transform schema therapy techniques into natural autobiographical experiences within a new virtual environment. This can gradually reshape the patient's schema modes, ultimately enabling more adaptive and inclusive interaction with the real world.
FRONTIERS IN PSYCHOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Jang Mi Han, Hye Jin Jung
Summary: The interaction between Cyclophilin A and CD147 plays a crucial role in multiple diseases, particularly in the progression of cancer. Their overexpression is associated with cancer cell growth, metastasis, therapeutic resistance, and stem cell-like properties, leading to poor prognosis in cancer patients. Therefore, targeting the Cyclophilin A/CD147 interaction may improve treatment outcomes for cancer patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cell Biology
Jiancheng Yang, Qinghua Tang, Yuhong Zeng
Summary: Iron overload is a common problem in chronic and common diseases, and melatonin has been found to have iron chelating and antioxidant properties, making it a potential therapy for iron overload-related disorders.
AGEING RESEARCH REVIEWS
(2022)
Review
Immunology
Hai Zhao, Shuangshuang Song, Junwei Ma, Zhiyong Yan, Hongwei Xie, Ying Feng, Shusheng Che
Summary: CD47 is a protein that is ubiquitously expressed on the surface of cells and plays a critical role in self-recognition. It modulates cellular phagocytosis, determines the lifespan of erythrocytes, regulates immune cell activation, and manipulates synaptic pruning during neuronal development. Recently, CD47 has been identified as a novel target for cancer immunotherapy. This review discusses the diverse functions of CD47, its role in immune system homeostasis, and its potential therapeutic roles against cancer.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Nils Kosiol, Stefan Juranek, Peter Brossart, Annkristin Heine, Katrin Paeschke
Summary: The importance of G4 structures in malignant cell characterization has been demonstrated, potentially enabling stratified treatment of breast cancer. G4 structures serve as therapeutic targets, with the development of targeted chemical molecules to disrupt cancer cell function.
Review
Neurosciences
Zhang Fan, Li Bin
Summary: Neuroinflammatory disorder refers to the progressive loss of neuronal structure or function. SIRT2, a member of the sirtuins, plays a crucial role in regulating immune homeostasis in neuroinflammatory disorders. Excessive neuroinflammation can damage the central nervous system, while appropriate neuroinflammatory response promotes brain homeostasis.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Review
Chemistry, Multidisciplinary
Yihui Gao, Mingzhe Ma, Wenyang Li, Xiaoguang Lei
Summary: Target deconvolution is a vital project in forward chemical genetic research, aiming to identify the molecular targets of active hit compounds. Chemoproteomics, employing either chemical probe-assisted target enrichment or probe-free methodologies, provides a straightforward and effective approach to profile the target landscape and unravel the mechanisms of action.
Review
Biochemistry & Molecular Biology
Amrutha Menon, Noraini Abd-Aziz, Kanwal Khalid, Chit Laa Poh, Rakesh Naidu
Summary: This review focuses on the role of miRNA in cancer, therapeutic approaches with miRNAs, and effective delivery into the system. Patents and ongoing clinical trials for miRNA therapy are also summarized.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Xiali Qin, Yu Gu, Tianyu Liu, Chen Wang, Weilong Zhong, Bangmao Wang, Hailong Cao
Summary: This review summarizes the current research progress on fungal dysbiosis in CRC, discusses the potential mechanisms of fungi in CRC development, and explores potential therapeutic strategies for CRC treatment. This contributes to a better understanding of the correlation between fungal community and CRC, with modulating fungal community being a promising target against CRC.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2021)
Review
Medicine, General & Internal
Yuhong Zhai, Jun Yang, Jing Zhang, Jian Yang, Qi Li, Tao Zheng
Summary: SFKs play a crucial role in the development of various cardiovascular diseases by regulating signaling pathways to maintain cardiovascular homeostasis. They have the potential to serve as diagnostic biomarkers and therapeutic targets, paving the way for further clinical applications.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2021)
Article
Medicine, Research & Experimental
Liu Ye, Beibei Liu, Jingling Huang, Xiaolin Zhao, Yuan Wang, Yungen Xu, Shuping Wang
Summary: Doublecortin-like kinase 1 (DCLK1) is a significant prooncogenic factor that is strongly associated with the malignant progression and clinical prognosis of various cancers. DCLK1 plays important roles in stem cell marker regulation, tumor cell reprogramming, and immune evasion. However, the exact biological functions of DCLK1, especially the disparities between its alpha- and beta-form transcripts in cancer progression, remain ambiguous.