Article
Biochemistry & Molecular Biology
Francisco J. Cimas, Miguel Angel De la Cruz-Morcillo, Carmen Cifuentes, Natalia Moratalla-Lopez, Gonzalo L. Alonso, Eduardo Nava, Silvia Llorens
Summary: CCT, a saffron-derived apocarotenoid, has anti-adipogenic, anti-inflammatory, and antioxidant activities. This study found that CCT decreased glycerol release and lipid accumulation, inhibited key lipolytic enzymes, and exhibited antioxidant and anti-inflammatory effects. These findings suggest that CCT may be a promising compound for improving lipid mobilisation in obesity.
Article
Pharmacology & Pharmacy
Chaiwat Monmai, Jin-Suk Kim, Hyun Bo Sim, Doh-Won Yun, Sung-Dug Oh, Eui-Shik Rha, Jong-Jin Kim, So-Hyeon Baek
Summary: This study evaluated the effects of extracts from transgenic rice on inhibiting adipogenesis and anti-inflammatory activity. The results showed that the extracts significantly reduced lipid accumulation in cells and inhibited the expression of adipogenesis-related mRNA and inflammation-related factors. Therefore, transgenic rice may have potential as an obesity-reducing and/or -preventing agent.
Article
Multidisciplinary Sciences
Sina Kavalakatt, Abdelkrim Khadir, Dhanya Madhu, Heikki A. Koistinen, Fahd Al-Mulla, Jaakko Tuomilehto, Jehad Abubaker, Ali Tiss
Summary: UCN3 has shown beneficial effects in adipocytes by improving cellular stress response and glucose uptake, as well as attenuating inflammation and apoptosis.
SCIENTIFIC REPORTS
(2021)
Article
Food Science & Technology
Jinhee Song, Hana Lee, Huijin Heo, Junsoo Lee, Younghwa Kim
Summary: We investigated the effects of chrysoeriol on fat cell formation and breakdown and identified the underlying mechanisms. Chrysoeriol inhibited fat accumulation in adipocytes and downregulated the expression of key genes involved in fat synthesis. Furthermore, chrysoeriol activated a protein kinase that promotes fat breakdown and increased the levels of free glycerol and fatty acids. Overexpression of specific enzymes for fat breakdown contributed to the enhanced lipolysis induced by chrysoeriol. Overall, chrysoeriol exhibited anti-adipogenic and lipolytic properties in fat cells.
Article
Biochemistry & Molecular Biology
Jennifer L. Bailey, Hardy Hang, Anik Boudreau, Carrie M. Elks
Summary: The study found that OSM induces adipocyte lipolysis via the p66Shc-ERK pathway, inhibiting the suppression of lipolysis by insulin, and inducing phosphorylation of inhibitory IRS1 residues.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Dahae Lee, Hee Jae Kwak, Byoung Ha Kim, Seung Hyun Kim, Dong-Wook Kim, Ki Sung Kang
Summary: The study investigated the anti-adipogenic effects of hispidulin and p-synephrine alone and in combination, with the combination showing greater inhibition of lipid droplet formation. It may be a potential alternative strategy for developing novel anti-obesity drugs.
Article
Biochemistry & Molecular Biology
Dahae Lee, Ji-Youn Kim, Hae-Won Kim, Jeong-Eun Yoo, Ki Sung Kang
Summary: The combination of genistein and atorvastatin significantly suppresses preadipocyte differentiation and downregulates adipogenic marker proteins, suggesting a potential alternative treatment for menopause-associated lipid metabolic disorders and obesity.
Article
Medicine, Research & Experimental
Farah Gulzar, Shadab Ahmad, Sushmita Singh, Pawan Kumar, Aditya Sharma, Akhilesh K. Tamrakar
Summary: This study demonstrates that activation of NOD1 in adipocytes can affect lipid metabolism in hepatocytes by promoting lipolysis and inflammatory responses. This effect is associated with enhanced transport of fatty acids and increased triglyceride synthesis rate in hepatocytes. Additionally, NOD1 activation induces inflammatory response and impairs insulin signaling in hepatocytes.
Article
Pharmacology & Pharmacy
Trang Thi Huyen Dang, Minji Choi, Huong Giang Pham, Jong Won Yun
Summary: Studies have shown that CYP2F2 can negatively regulate lipid metabolism and browning in adipocytes by inhibiting the activation of β-3 adrenergic receptor and its downstream regulators. Inhibitors of CYP2F2 could potentially be used as drugs for treating obesity by enhancing energy expenditure.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Nutrition & Dietetics
Tomohiko Nakao, Shiro Otaki, Yuri Kominami, Soichi Watanabe, Miho Ito, Teruki Aizawa, Yusuke Akahori, Hideki Ushio
Summary: L-fucose (Fuc) demonstrates potent anti-obesity effects in mice, however, the underlying mechanisms are not fully understood. This study investigates the effects of Fuc on lipid metabolism and insulin signaling in 3T3-L1 adipocytes. Fuc treatment suppresses lipid accumulation and activates the AMPK pathway, responsible for regulating fatty acid oxidation and lipolysis. Fuc also promotes glucose uptake via Akt activation in an insulin-resistant state. These findings provide insights into the mechanism of Fuc's anti-obesity effects and its potential as a therapeutic compound.
Article
Biochemistry & Molecular Biology
Yu-Kyoung Park, Byeong-Churl Jang
Summary: The study revealed that the receptor tyrosine kinase c-Met plays a crucial role in embryogenesis, morphogenesis, metabolism, cell growth, and differentiation. JNJ38877605 (JNJ), an inhibitor of c-Met, showed anti-tumor activity. In this research, the expression and phosphorylation of c-Met, as well as its effects on fat accumulation, were investigated in murine preadipocyte 3T3-L1 cells. The findings demonstrated that c-Met is a novel mediator of adipogenesis, regulating lipid accumulation in adipocytes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
You Chul Chung, Chang-Gu Hyun
Summary: Pinostilbene hydrate (PH) inhibits adipogenesis in 3T3-L1 cells by reducing lipid accumulation and triglyceride content without cytotoxicity. It works through multiple pathways, including activation of the AMPK signaling pathway and inhibition of MAPK and AKT insulin-dependent signaling pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Su Jin Lee, Ji Eun Kim, Yun Ju Choi, Jeong Eun Gong, You Jeong Jin, Da Woon Lee, Young Whan Choi, Dae Youn Hwang
Summary: Alpha-cubebenol isolated from Schisandra chinensis shows novel roles as a lipogenesis inhibitor, lipolysis and beta-oxidation stimulator, and inflammasome suppressor in MDI-stimulated 3T3-L1 adipocytes, without significant cytotoxic effects.
Article
Biotechnology & Applied Microbiology
Eleanor H. Oates, Maciek R. Antoniewicz
Summary: Hypoxia has a significant impact on the physiology and metabolism of adipocytes, leading to the suppression of adipogenesis, de novo lipogenesis, and metabolic reprogramming. It alters the patterns of cellular metabolism, redirects glucose metabolism, rewires glutamine metabolism, suppresses branched chain amino acid consumption, and reduces the biosynthesis of certain fatty acids.
METABOLIC ENGINEERING
(2023)
Article
Biotechnology & Applied Microbiology
Wanfeng Xu, Ling Hou, Ping Li, Ling Li
Summary: The interference of NNMT expression was found to reduce lipid accumulation and triglyceride content, as well as decrease the expression of certain genes and proteins related to lipid metabolism. This suggests that NNMT plays an important role in the function and metabolism of adipocytes.