Improved Radiosynthesis and Biological Evaluations of L- and D-1-[18F]Fluoroethyl-Tryptophan for PET Imaging of IDO-Mediated Kynurenine Pathway of Tryptophan Metabolism

Fully automated radiosynthesis of N1-[18F]fluoroethyl-tryptophan and study of its biological activity as a new potential substrate for indoleamine 2,3-dioxygenase PET imaging

(2016) Jean Henrottin et al.   NUCLEAR MEDICINE AND BIOLOGY

Design and automated production of 11C-alpha-methyl-l-tryptophan (11C-AMT)

(2016) Xuan Huang et al.   NUCLEAR MEDICINE AND BIOLOGY

IDO in the Tumor Microenvironment: Inflammation, Counter-Regulation, and Tolerance

(2016) David H. Munn et al.   TRENDS IN IMMUNOLOGY

Big opportunities for small molecules in immuno-oncology

(2015) Jerry L. Adams et al.   NATURE REVIEWS DRUG DISCOVERY

N1-Fluoroalkyltryptophan Analogues: Synthesis and in vitro Study as Potential Substrates for Indoleamine 2,3-Dioxygenase

(2015) Jean Henrottin et al.   ACS Medicinal Chemistry Letters

First Clinical Results of (D)-18F-Fluoromethyltyrosine (BAY 86-9596) PET/CT in Patients with Non-Small Cell Lung Cancer and Head and Neck Squamous Cell Carcinoma

(2014) I. A. Burger et al.   JOURNAL OF NUCLEAR MEDICINE

Synthesis and biological evaluation of 18F-labeled fluoropropyl tryptophan analogs as potential PET probes for tumor imaging

(2013) Aristeidis Chiotellis et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Up-regulated expression of indoleamine 2,3-dioxygenase 1 in non-Hodgkin lymphoma correlates with increased regulatory T-cell infiltration

(2013) Xiao-Qian Liu et al.   LEUKEMIA & LYMPHOMA

5-(2-18F-Fluoroethoxy)-L-Tryptophan as a Substrate of System L Transport for Tumor Imaging by PET

(2012) S. D. Kramer et al.   JOURNAL OF NUCLEAR MEDICINE

Kynurenines in the CNS: recent advances and new questions

(2012) László Vécsei et al.   NATURE REVIEWS DRUG DISCOVERY

Tryptophan metabolism in breast cancers: molecular imaging and immunohistochemistry studies

(2012) Csaba Juhász et al.   NUCLEAR MEDICINE AND BIOLOGY

Radiosynthesis of 1-[18F]fluoroethyl-L-tryptophan as a novel potential amino acid PET tracer

(2011) Ting Sun et al.   APPLIED RADIATION AND ISOTOPES

Indoleamine 2,3-Dioxygenase Expression in Human Cancers: Clinical and Immunologic Perspectives

(2011) J. Godin-Ethier et al.   CLINICAL CANCER RESEARCH

Next-generation mTOR inhibitors in clinical oncology: how pathway complexity informs therapeutic strategy

(2011) Seth A. Wander et al.   JOURNAL OF CLINICAL INVESTIGATION

Serum concentration of L-kynurenine predicts the clinical outcome of patients with diffuse large B-cell lymphoma treated with R-CHOP

(2009) Takeshi Yoshikawa et al.   EUROPEAN JOURNAL OF HAEMATOLOGY

Imaging Correlates of Differential Expression of Indoleamine 2,3-Dioxygenase in Human Brain Tumors

(2009) Carlos E. A. Batista et al.   MOLECULAR IMAGING AND BIOLOGY

Non-natural amino acids for tumor imaging using positron emission tomography and single photon emission computed tomography

(2008) Jonathan McConathy et al.   CANCER AND METASTASIS REVIEWS