CRISPR-Cas9 induced mutations along de novo purine synthesis in HeLa cells result in accumulation of individual enzyme substrates and affect purinosome formation
CRISPR-Cas9 induced mutations along de novo purine synthesis in HeLa cells result in accumulation of individual enzyme substrates and affect purinosome formation
作者
关键词
De novo purine synthesis, Adenylosuccinate lyase deficiency, AICA-ribosiduria, CRISPR, Human cellular model, Purinosome
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