Article
Surgery
Rohit Gaurav, Andrew J. Butler, Vasilis Kosmoliaptsis, Lisa Mumford, Corrina Fear, Lisa Swift, Arturs Fedotovs, Sara Upponi, Samir Khwaja, James Richards, Michael Allison, Christopher J. E. Watson
Summary: NRP and NMP were associated with better early liver function compared to SCS, whereas NRP was associated with superior preservation of the biliary system.
Article
Surgery
Jose Luis Campo-Canaveral de la Cruz, Eduardo Minambres, Elisabeth Coll, Maria Padilla, Gloria Sanchez Antolin, Gloria de la Rosa, Joel Rosado, Francisco Javier Gonzalez Garcia, Silvana Crowley Carrasco, Gabriel Sales Badia, Eva Maria Fieria Costa, Jose Alberto Garcia Salcedo, Victor Mora, Carlos de la Torre, Rafael Badenes, Lander Atutxa Bizkarguenaga, Beatriz Dominguez-Gil
Summary: This study aimed to investigate the outcomes of lung and liver transplantation using NRP in cDCD donors and compare them with transplants using DBD grafts. The results showed that simultaneous transplantation of lungs and livers from cDCD donors using NRP offers similar outcomes to transplants using DBD grafts.
AMERICAN JOURNAL OF TRANSPLANTATION
(2023)
Review
Biotechnology & Applied Microbiology
Chuanyan Shen, Hongwei Cheng, Tingting Zong, Hongli Zhu
Summary: The gap between the number of liver transplant patients and available donors is a significant issue in the field of transplantation. Limited access to liver transplantation has led to the use of extended criteria donors to address the growing demand. Preservation before transplantation plays a crucial role in determining patient outcomes, and the use of normothermic machine perfusion shows promise in improving graft viability and assessing viability before transplantation. This review provides an overview of normothermic machine perfusion and its application in liver preservation and pre-transplantation, as well as data from current clinical trials.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Pierre-Alain Clavien, Philipp Dutkowski, Matteo Mueller, Dilmurodjon Eshmuminov, Lucia Bautista Borrego, Achim Weber, Beat Muellhaupt, Richard X. Sousa Da Silva, Brian R. Burg, Philipp Rudolf von Rohr, Martin J. Schuler, Dustin Becker, Max Hefti, Mark W. Tibbitt
Summary: A human liver has been successfully transplanted using ex situ normothermic machine perfusion, which extends the time window for evaluating the viability of donor organs and transforms the urgency of the surgery to an elective procedure.
NATURE BIOTECHNOLOGY
(2022)
Article
Immunology
Zhiyong Guo, Liqiang Zhan, Ningxin Gao, Zhiheng Zhang, Shanzhou Huang, Linhe Wang, Caihui Zhu, Zehua Jia, Meixian Yin, Fangcong Li, Shirui Chen, Tao Luo, Yao Liu, Yu Jia, Tielong Wang, Jinghong Xu, Yuexin Li, Yifan Zhu, Yichao Chen, Chuhan Yu, Yunhua Tang, Qiang Zhao, Dongping Wang, Xiaoshun He
Summary: This study compared the metabolism activities of donor livers between in situ and ex situ conditions during ischemia-free liver transplantation. Common and distinct metabolites were identified, indicating suppressed urea cycle pathway and more active metabolism in standard criteria donor group. These findings provide insights for improving perfusion device design, perfusate components, and graft viability criteria.
Article
Surgery
Takayuki Yamamoto, Srilakshmi Atthota, Divyansh Agarwal, Kerry Crisalli, Malcolm Macconmara, Tsukasa Nakamura, Richard Teo, Leigh Anne Dageforde, Shoko Kimura, Nahel Elias, Heidi Yeh, Adel Bozorgzadeh, Tatsuo Kawai, James F. Markmann
Summary: This study compares the outcomes of liver allografts preserved using portable normothermic machine perfusion (NMP) and ischemic cold storage (ICS) in liver transplantation procedures. It concludes that NMP can significantly reduce the incidence of early allograft dysfunction, reperfusion syndrome, and ischemic cholangiopathy after donation after circulatory death (DCD) liver transplantation.
Review
Surgery
Belle Liew, David Nasralla, Satheesh Iype, Joerg-Matthias Pollok, Brian Davidson, Dimitri A. Raptis
Summary: Machine perfusion, especially hypothermic machine perfusion, showed advantages in reducing early allograft dysfunction and improving recipient outcomes in liver transplant surgeries. Normothermic machine perfusion was associated with reduced graft injury and major complication risks. Both techniques have the potential to lead to cost savings.
BRITISH JOURNAL OF SURGERY
(2021)
Article
Surgery
Suk Kyun Hong, Sunho Choe, Nam-Joon Yi, Aesun Shin, Eun Kyung Choe, Kyung Chul Yoon, Kwang-Woong Lee, Kyung-Suk Suh
Summary: The study evaluated the long-term mortality of Korean live liver donors by comparing it with the mortality of the general population, finding that liver donors have slightly higher long-term mortality rates. The most common causes of death were suicide, cancer, and traffic accidents.
Article
Gastroenterology & Hepatology
Margarita Fernandez-de la Varga, Pablo del Pozo-del Valle, Sergio Bejar-Serrano, Rafael Lopez-Andujar, Marina Berenguer, Martin Prieto, Eva Montalva, Victoria Aguilera
Summary: This study compared the incidence of complications between liver transplant recipients receiving donors after circulatory death (DCD) and those receiving donors after brain death (DBD). The results showed that DCD recipients had a higher rate of biliary complications, postoperative bleeding, and reinterventions. However, there were no significant differences in graft and patient survival rates between the two groups at 1, 2, 3, and 4 years.
ANNALS OF HEPATOLOGY
(2022)
Article
Medicine, General & Internal
Janina Eden, Eva Breuer, Dominique Birrer, Matteo Mueller, Matthias Pfister, Hemma Mayr, Keyue Sun, Jeannette Widmer, Florian Huwyler, Udo Ungethuem, Bostjan Humar, Anurag Gupta, Stefanie Schiess, Martin Wendt, Franz Immer, Andreas Elmer, David Meierhofer, Andrea Schlegel, Philipp Dutkowski
Summary: This study reports on the concept of liver assessment during ex situ hypothermic oxygenated perfusion (HOPE) and emphasizes its significant impact on liver utilization. The findings show that HOPE treatment combined with viability assessment is highly suitable for evaluating liver grafts, enabling surgeons to make informed decisions on whether to proceed with the transplant.
Article
Medicine, General & Internal
Hiroyoshi Iwata, Hiromichi Obara, Tetsuya Nakajo, Hiroki Kaneko, Yuga Okazawa, Nur Khatijah Mohd Zin, Hiroki Bochimoto, Makito Ohashi, Yoko Kawada, Mizuho Ohara, Hideki Yokoo, Naoto Matsuno
Summary: This study investigated the benefits of using subnormothermic extracorporeal membrane oxygenation (ECMO) and hypothermic machine perfusion (HMP) in a porcine model of liver transplantation from donors after cardiac death (DCD). The results suggested that the combination of ECMO and HMP could improve the functional outcome of DCD liver grafts.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Multidisciplinary Sciences
Nicolas Sauthier, Rima Bouchakri, Francois Martin Carrier, Michael Sauthier, Louis-Antoine Mullie, Heloise Cardinal, Marie-Chantal Fortin, Nadia Lahrichi, Michael Chasse
Summary: Organ donation cannot meet the demand, and a large percentage of potential donors are not identified. We developed an automated screening system based on machine learning to reduce missed eligible organ donors. The neural network model we developed showed high accuracy and stability in identifying potential organ donors.
SCIENTIFIC REPORTS
(2023)
Article
Medicine, General & Internal
Stefano Mastrobuoni, Manuel Johanns, Martial Vergauwen, Gwen Beaurin, Mark Rider, Pierre Gianello, Alain Poncelet, Olivier Van Caenegem
Summary: Transplantation of heart following donation after circulatory death (DCD) has been introduced into clinical practice. In a porcine model of DCD heart, we tested the effect of different temperatures on cardiac metabolism during ex vivo reperfusion. We observed a steep fall in ATP concentrations at the end of warm ischemic time, limited regeneration during reperfusion, and an increase in lactate concentration. However, the temperature did not have an effect on ATP or lactate concentration. Additionally, all cardiac allografts experienced significant weight increase due to cardiac edema, regardless of the temperature.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Surgery
Laura DiChiacchio, Matthew L. Goodwin, Hiroshi Kagawa, Eric Griffiths, Ian C. Nickel, Josef Stehlik, Craig H. Selzman
Summary: Heart transplantation is the preferred treatment for end-stage heart failure, but there is a lack of available donor hearts. Donating hearts following circulatory death is a potential solution to increase the donor pool.
JOURNAL OF SURGICAL RESEARCH
(2023)
Review
Gastroenterology & Hepatology
Marianna Maspero, Khaled Ali, Beatrice Cazzaniga, Sumeyye Yilmaz, Roma Raj, Qiang Liu, Cristiano Quintini, Charles Miller, Koji Hashimoto, Robert L. Fairchild, Andrea Schlegel
Summary: Dynamic organ perfusion techniques, such as hypothermic oxygenated perfusion, are associated with a reduction in acute cellular rejection after liver transplantation compared with static cold storage.
Article
Surgery
Kenji Okumura, Jeffrey Baum, Romeo Mateo, Ilya Shnaydman
Article
Immunology
Abhay Dhand, Kenji Okumura, Christopher Nabors, Seigo Nishida
Summary: This study analyzed the utilization of organs from donors with COVID-19 and their short-term outcomes using the UNOS database. The results showed that the short-term outcomes of non-lung solid organ transplantation from COVID+ donors were similar to those from COVID- donors, indicating that a positive COVID test should not preclude consideration of these donors for transplantation.
TRANSPLANT INFECTIOUS DISEASE
(2023)
Letter
Surgery
Kenji Okumura, Seigo Nishida, Abhay Dhand
CLINICAL TRANSPLANTATION
(2023)
Article
Cardiac & Cardiovascular Systems
Suguru Ohira, Kenji Okumura, Stephen Pan, Abhay Dhand, Elliot Levine, Corazon B. De La Pena, Seigo Nishida, David Spielvogel, Masashi Kai
Summary: The new heart allocation policy is associated with decreased overall survival and increased heart and kidney graft failure in combined heart and kidney transplantation recipients.
CIRCULATION-HEART FAILURE
(2023)
Article
Immunology
Kenji Okumura, Soma Jyothula, Thomas Kaleekal, Abhay Dhand
Summary: The characteristics and outcomes of lung transplant recipients with COVID-19-associated end-stage lung disease were analyzed. The study found that COVID-19 patients had longer hospital stays after transplant, but one-year patient survival was similar to non-COVID-19 recipients. However, COVID-19 remained one of the most common causes of death during the immediate post-transplant period.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Surgery
Kamil Hanna, Bardiya Zangbar, Jordan Kirsch, Matthew Bronstein, Kenji Okumura, Shekhar Gogna, Ilya Shnaydman, Kartik Prabhakaran, Jorge Con
Summary: This study compared the outcomes of cholecystectomy and nonoperative management in cirrhotic patients with acute calculous cholecystitis. The results showed a higher failure rate of nonoperative management, longer length of stay, and higher mortality in these patients.
AMERICAN JOURNAL OF SURGERY
(2023)
Letter
Surgery
Kenji Okumura, Suguru Ohira, Ryosuke Misawa, Abhay Dhand, Seigo Nishida
AMERICAN JOURNAL OF TRANSPLANTATION
(2023)
Article
Surgery
Ameesh Isath, Vasiliki Gregory, Suguru Ohira, Avi Levine, Abhay Dhand, Igor Laskowski, Romeo Mateo, Sateesh Babu, David Spielvogel, Masashi Kai
Summary: The management of groin complications in heart transplant recipients after perioperative femoral VA-ECMO is uncertain. Sartorius muscle flaps (SMF) may be a useful tool to prevent infection progression and improve local healing.
CLINICAL TRANSPLANTATION
(2023)
Article
Surgery
Rahim Hirani, Kenji Okumura, Ameesh Isath, Vasiliki Gregory, Shazli Khan, Abhay Dhand, Gregg M. Lanier, David Spielvogel, Masashi Kai, Suguru Ohira
Summary: The outcomes of heart transplantation using HCV+ (hepatitis C virus positive) donor organs in recipients with underlying liver disease are unclear. Comparison between recipients with elevated MELD-XI scores (excluding international normalized ratio) who received heart transplantations from HCV+ donors and HCV-negative donors showed that utilization of HCV+ hearts did not increase the risk of adverse outcomes.
CLINICAL TRANSPLANTATION
(2023)
Article
Surgery
Kenji Okumura, Abhay Dhand, Ryosuke Misawa, Hiroshi Sogawa, Gregory Veillette, Seigo Nishida
Summary: This study assessed the impact of the acuity circle policy on racial disparities in liver transplantation and found that it did not alter waitlist mortality or improve post-transplant outcomes for Black recipients.
