Comprehensive genomic profiling reveals molecular subsets of ASXL1 -mutated myeloid neoplasms

A reappraisal of ASXL1 mutation sites and the cohesin-binding motif in myeloid disease

(2023) Steven M. Johnson et al.   Blood Cancer Journal

Therapeutic targeting of BAP1/ASXL3 sub-complex in ASCL1-dependent small cell lung cancer

(2022) Natsumi Tsuboyama et al.   ONCOGENE

Clinical, biological, and prognostic implications of SF3B1 co-occurrence mutations in very low/low- and intermediate-risk MDS patients

(2021) Kamila Janusz et al.   ANNALS OF HEMATOLOGY

Genomic characteristics and prognostic significance of co‐mutated ASXL1 / SRSF2 acute myeloid leukemia

(2021) Daniel R. Richardson et al.   AMERICAN JOURNAL OF HEMATOLOGY

Chromatin-Spliceosome Mutations in Acute Myeloid Leukemia

(2021) Yotaro Ochi et al.   Cancers

Impact of splicing mutations in acute myeloid leukemia treated with hypomethylating agents combined with venetoclax

(2021) Curtis A. Lachowiez et al.   Blood Advances

ASXL1 mutation as a surrogate marker in acute myeloid leukemia with myelodysplasia-related changes and normal karyotype

(2020) Concepción Prats-Martín et al.   Cancer Medicine

Molecular landscape and clonal architecture of adult myelodysplastic/myeloproliferative neoplasms

(2020) Laura Palomo et al.   BLOOD

Clinical significance of chromatin-spliceosome acute myeloid leukemia: a report from the Northern Italy Leukemia Group (NILG) randomized trial 02/06

(2020) Chiara Caprioli et al.   HAEMATOLOGICA

Spectrum of ASXL1 mutations in primary myelofibrosis: prognostic impact of the ASXL1 p.G646Wfs*12 mutation

(2019) Giada Rotunno et al.   BLOOD

Prognostic significance of mutation profile at diagnosis and mutation persistence during disease remission in adult acute myeloid leukaemia patients

(2019) Adam Folta et al.   BRITISH JOURNAL OF HAEMATOLOGY

EZH2 mutations and impact on clinical outcome - an analysis in 1604 patients with newly diagnosed acute myeloid leukemia

(2019) Sebastian Stasik et al.   HAEMATOLOGICA

Reduced BAP1 activity prevents ASXL1 truncation-driven myeloid malignancy in vivo

(2018) Ying Guo et al.   LEUKEMIA

Mutant ASXL1 cooperates with BAP1 to promote myeloid leukaemogenesis

(2018) Shuhei Asada et al.   Nature Communications

EZH2 mutations in chronic myelomonocytic leukemia cluster with ASXL1 mutations and their co-occurrence is prognostically detrimental

(2018) Mrinal M. Patnaik et al.   Blood Cancer Journal

Distinct age-associated molecular profiles in acute myeloid leukemia defined by comprehensive clinical genomic profiling

(2018) Katherine Tarlock et al.   Oncotarget

Mutations and karyotype predict treatment response in myelodysplastic syndromes

(2018) Dame Idossa et al.   AMERICAN JOURNAL OF HEMATOLOGY

Clinical molecular testing for ASXL1 c.1934dupG p.Gly646fs mutation in hematologic neoplasms in the NGS era

(2018) Santiago Montes-Moreno et al.   PLoS One

The distinct biological implications of Asxl1 mutation and its roles in leukemogenesis revealed by a knock-in mouse model

(2017) Yueh-Chwen Hsu et al.   Journal of Hematology & Oncology

Standards and Guidelines for the Interpretation and Reporting of Sequence Variants in Cancer

(2017) Marilyn M. Li et al.   JOURNAL OF MOLECULAR DIAGNOSTICS

Prognostic significance of ASXL1 mutation types and allele burden in myelofibrosis

(2017) A Tefferi et al.   LEUKEMIA

ASXL1 c.1934dup;p.Gly646Trpfs*12—a true somatic alteration requiring a new approach

(2017) Costas K. Yannakou et al.   Blood Cancer Journal

Integrated genomic DNA/RNA profiling of hematologic malignancies in the clinical setting

(2016) J. He et al.   BLOOD

Diagnosis and management of AML in adults: 2017 ELN recommendations from an international expert panel

(2016) Hartmut Döhner et al.   BLOOD

Genomic Classification and Prognosis in Acute Myeloid Leukemia

(2016) Elli Papaemmanuil et al.   NEW ENGLAND JOURNAL OF MEDICINE

ASXL1 mutations in younger adult patients with acute myeloid leukemia: a study by the German-Austrian Acute Myeloid Leukemia Study Group

(2015) P. Paschka et al.   HAEMATOLOGICA

Systematic identification of cancer driving signaling pathways based on mutual exclusivity of genomic alterations

(2015) Özgün Babur et al.   GENOME BIOLOGY

ASXL1 mutations in younger adult patients with acute myeloid leukemia: a study by the German-Austrian Acute Myeloid Leukemia Study Group

(2015) P. Paschka et al.   HAEMATOLOGICA

Acute myeloid leukemia ontogeny is defined by distinct somatic mutations

(2014) R. C. Lindsley et al.   BLOOD

Preleukemic mutations in human acute myeloid leukemia affect epigenetic regulators and persist in remission

(2014) M. R. Corces-Zimmerman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Loss of Asxl1 leads to myelodysplastic syndrome-like disease in mice

(2013) J. Wang et al.   BLOOD

Landscape of genetic lesions in 944 patients with myelodysplastic syndromes

(2013) T Haferlach et al.   LEUKEMIA

Development and validation of a clinical cancer genomic profiling test based on massively parallel DNA sequencing

(2013) Garrett M Frampton et al.   NATURE BIOTECHNOLOGY

ASXL1 mutations identify a high-risk subgroup of older patients with primary cytogenetically normal AML within the ELN Favorable genetic category

(2011) K. H. Metzeler et al.   BLOOD

Clinical Effect of Point Mutations in Myelodysplastic Syndromes

(2011) Rafael Bejar et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mutual exclusion of ASXL1 and NPM1 mutations in a series of acute myeloid leukemias

(2009) N Carbuccia et al.   LEUKEMIA