Article
Biochemistry & Molecular Biology
Waqas Azeem, Jan Roger Olsen, Margrete Reime Hellem, Yaping Hua, Kristo Marvyin, Xisong Ke, Anne Margrete oyan, Karl-Henning Kalland
Summary: This study investigated the role of GATA2 in prostate epithelial cells and found that exogenous GATA2 protein was rapidly degraded and its expression could be rescued by proteasome inhibitors. The inhibition of proteasome also induced the transcription of AR mRNA and luminal marker genes in prostate cells. Different intrinsic mechanisms restricted the expression of GATA2 in these cells. These findings suggest the existence of crucial cofactors for AR mRNA expression and luminal differentiation at the proteolytic level.
Article
Biochemistry & Molecular Biology
Isabel L. L. Woodman
Summary: The prostate is regulated by androgen and involves complex cellular and molecular interactions. This study proposes a conceptual framework that describes the androgen-dependent regulation of prostate epithelial dynamics. A mathematical model based on this framework fits experimental data well and provides insights into potential disease mechanisms. This simple model could serve as a foundation for more comprehensive modelling of the healthy and diseased prostate.
Review
Biochemistry & Molecular Biology
Rahul Advani, Sara Luzzi, Emma Scott, Caroline Dalgliesh, Joachim Weischenfeldt, Jennifer Munkley, David J. Elliott
Summary: This article discusses the expression of splicing regulators ESRP1 and ESRP2 in aggressively proliferating primary prostate tumors as markers of disease progression. It suggests that ESRP1 and ESRP2 act as lineage survival oncogenes in prostate cancer and highlights the need to identify the gene expression targets controlled by these regulators to develop targeted therapies.
Article
Multidisciplinary Sciences
Fabrizia Pipicelli, Natalia Baumann, Rossella Di Giaimo, Andrea Forero-Echeverry, Christina Kyrousi, Rebecca Bonrath, Giuseppina Maccarrone, Denis Jabaudon, Silvia Cappello
Summary: Disruption in neurogenesis and neuronal migration can disrupt cortical circuit assembly and lead to neurodevelopmental and neuropsychiatric disorders. Extracellular vesicles released in the external environment were found to regulate neuronal molecular differentiation and alter migratory dynamics. These findings suggest that extracellular vesicles may play a role in modulating neuronal development.
Article
Cell Biology
Yueli Liu, Jiawen Wang, Corrigan Horton, Chuan Yu, Beatrice Knudsen, Joshua Stefanson, Kevin Hu, Ofir Stefanson, Jonathan Green, Charlene Guo, Qing Xie, Zhu A. Wang
Summary: This study reveals that stromal AR inhibits prostate cancer progression by restraining secretory luminal cells, and deletion of stromal AR exacerbates tumor progression and leads to changes in the cellular state of secretory luminal cells.
Review
Oncology
Jianling Xie, Eric P. Kusnadi, Luc Furic, Luke A. Selth
Summary: Estrogen and androgen receptors are key drivers in breast and prostate cancer, regulating mRNA translation to influence cellular protein production and enhance cancer cell growth. Targeting mRNA translation could be a potential strategy for treating breast and prostate cancer.
Article
Oncology
Kumar Nikhil, Hanan S. Haymour, Mohini Kamra, Kavita Shah
Summary: This study identified that LIMK2 degrades SPOP by direct phosphorylation and creates a feedback loop to promote oncogenicity in prostate cancer. Understanding the relationship between LIMK2 and SPOP provides a powerful opportunity to inhibit LIMK2 and retain WT-SPOP, effectively halting disease progression.
BRITISH JOURNAL OF CANCER
(2021)
Article
Multidisciplinary Sciences
Mark D. Long, Vineet K. Dhiman, Hayley C. Affronti, Qiang Hu, Song Liu, Dominic J. Smiraglia
Summary: Understanding the epigenetic control of normal differentiation programs can provide valuable information about the disrupted regulatory states in cancer. By studying the luminal cell differentiation trajectory in prostate cancer cells exposed to androgens, and analyzing DNA methylation dynamics using whole genome bisulfite sequencing, researchers found that aberrant methylation patterns observed in prostate cancer are influenced by the normal dynamics of DNA methylation in the luminal differentiation program.
SCIENTIFIC REPORTS
(2021)
Article
Cell Biology
Yejin Kim, Dahae Lee, Hyejung Jo, Cheolhyeon Go, Jongwon Yang, Dongmin Kang, Jae Seung Kang
Summary: GV1001 effectively suppresses the proliferation of prostate cells, including stromal myofibroblasts and epithelial cells, by regulating cell growth and reducing hypertrophy. It also prevents prostatic fibrosis by inhibiting epithelial-mesenchymal transition through competing with testosterone for binding to androgen receptors, suggesting its potential as a therapeutic drug for BPH with fibrosis.
Article
Multidisciplinary Sciences
Katherin Patsch, Chao Liu, Grzegorz Zapotoczny, Yuanye Sun, Harish Sura, Nolan Ung, Ren X. Sun, Bethany Haliday, Chen Yu, Mayada Aljehani, Jerry S. H. Lee, Boris A. Kashemirov, David B. Agus, Charles E. McKenna, Daniel Ruderman
Summary: This study identified a new mechanism of drug resistance in lethal prostate cancer and discovered a structurally contradictory stereoisomer in a drug compound, suggesting new strategies to overcome drug resistance mechanisms.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Biochemistry & Molecular Biology
Versha Dahiya, Gargi Bagchi
Summary: Androgen signaling is crucial for the development of male organs, including the prostate. In addition to the classical pathways, there are non-canonical pathways that have a significant impact on androgen signaling and prostate cancer growth. Understanding these pathways can lead to important interventions for prostate cancer patients.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2022)
Article
Oncology
Jiapei Yuan, Kathleen E. Houlahan, Susmita G. Ramanand, Sora Lee, GuemHee Baek, Yang Yang, Yong Chen, Douglas W. Strand, Michael Q. Zhang, Paul C. Boutros, Ram S. Mani
Summary: Prostate cancer is highly heritable and researchers have identified multiple risk alleles associated with the disease. This study used three-dimensional spatial genomics to identify the target genes regulated by these risk alleles in prostate tumors. The findings revealed the complex regulation of these genes and their interactions with different tumor types.
Review
Endocrinology & Metabolism
Marisa A. A. Bickel, Boglarka Csik, Rafal Gulej, Anna Ungvari, Adam Nyul-Toth, Shannon M. M. Conley
Summary: Age-related cerebrovascular pathologies, including microvascular alterations and large vessel atherosclerosis, contribute to vascular cognitive impairment and dementia (VCID) and worsen Alzheimer's disease. Recent studies on heterochronic parabiosis models suggest that cell non-autonomous mechanisms are involved in regulating cerebrovascular aging processes. Decreased levels of growth hormone (GH) and insulin-like growth factor 1 (IGF-1) in aging individuals play a significant role in the development of cerebrovascular pathologies and VCID. Understanding the role of age-related GH/IGF-1 deficiency in cerebrovascular aging is crucial for identifying interventions to promote brain health in older adults.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Neurosciences
Elena G. Sergeeva, Paul A. Rosenberg, Larry Benowitz
Summary: The text describes the process of how visual information is transmitted from the eye to the brain through the optic nerve by retinal ganglion cells. It discusses the inability of retinal ganglion cells to regenerate axons and the mechanisms behind neurodegeneration and regenerative failure. Additionally, it mentions the role of retinal interneurons in the survival and axon regeneration of retinal ganglion cells.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Michele Iuliani, Sonia Simonetti, Giulia Ribelli, Silvia Cavaliere, Bruno Vincenzi, Giuseppe Tonini, Francesco Pantano, Daniele Santini
Summary: Abiraterone, a selective inhibitor of androgen biosynthesis, has been approved for the treatment of prostate cancer. This study provides evidence that abiraterone can inhibit prostate cancer cell proliferation through modulation of multiple osteoblast proliferative signals.
Article
Ecology
Ziv Frankenstein, David Basanta, Omar E. Franco, Yan Gao, Rodrigo A. Javier, Douglas W. Strand, MinJae Lee, Simon W. Hayward, Gustavo Ayale, Alexander R. A. Anderson
NATURE ECOLOGY & EVOLUTION
(2020)
Article
Developmental Biology
Alicia R. England, Christopher P. Chaney, Amrita Das, Mohita Patel, Alicia Malewska, Daniel Armendariz, Gary C. Hon, Douglas W. Strand, Keri A. Drake, Thomas J. Carroll
Article
Endocrinology & Metabolism
Diya B. Joseph, Gervaise H. Henry, Alicia Malewska, Nida S. Iqbal, Hannah M. Ruetten, Anne E. Turco, Lisa L. Abler, Simran K. Sandhu, Mark T. Cadena, Venkat S. Malladi, Jeffrey C. Reese, Ryan J. Mauck, Jeffrey C. Gahan, Ryan C. Hutchinson, Claus G. Roehrborn, Linda A. Baker, Chad M. Vezina, Douglas W. Strand
Article
Cell Biology
Sajjan Koirala, Jonathon Klein, Yumei Zheng, Nicole O. Glenn, Travis Eisemann, Klementina Fon Tacer, Darcie J. Miller, Ozlem Kulak, Meifen Lu, David B. Finkelstein, Geoffrey Neale, Heather Tillman, Peter Vogel, Douglas W. Strand, Lawrence Lum, Chad A. Brautigam, John M. Pascal, Wilson K. Clements, Patrick Ryan Potts
Article
Cell & Tissue Engineering
Mengle Shao, Chelsea Hepler, Qianbin Zhang, Bo Shan, Lavanya Vishvanath, Gervaise H. Henry, Shangang Zhao, Yu A. An, Yibo Wu, Douglas W. Strand, Rana K. Gupta
Summary: Regional differences in adipose precursor cells' response to obesity are driven by HIF alpha-induced PDGFR beta signaling, leading to inhibitory phosphorylation of PPAR gamma. Suppression of HIF alpha promotes adipogenesis and improves metabolic health in obesity, with potential for pharmacological targeting of APCs to enhance metabolic health.
Article
Developmental Biology
Diya B. Joseph, Anne E. Turco, Chad M. Vezina, Douglas W. Strand
Summary: The prostate develops through epithelial budding and branching processes during fetal and postnatal stages, showing remarkable regenerative capacity. Benign prostatic hyperplasia (BPH) and prostate cancer (PCa) may involve androgen-independent epithelial progenitors. Multiple castration-insensitive epithelial cell types exist in the proximal area of the prostate, with not all acting as progenitors.
DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Diya B. Joseph, Gervaise H. Henry, Alicia Malewska, Jeffrey C. Reese, Ryan J. Mauck, Jeffrey C. Gahan, Ryan C. Hutchinson, Venkat S. Malladi, Claus G. Roehrborn, Chad M. Vezina, Douglas W. Strand
Summary: Through single-cell RNA sequencing, different stromal cell types in the human prostate were identified, including three smooth muscle subtypes and two fibroblast subtypes. The research provides insight into the molecular identity and anatomy of discrete stromal cell types in the prostate, laying the foundation for new therapeutic targets in benign prostatic hyperplasia.
JOURNAL OF PATHOLOGY
(2021)
Article
Endocrinology & Metabolism
RenJie Jin, Douglas W. Strand, Connor M. Forbes, Thomas Case, Justin M. M. Cates, Qi Liu, Marisol Ramirez-Solano, Ginger L. Milne, Stephanie Sanchez, Zunyi Y. Wang, Dale E. Bjorling, Nicole L. Miller, Robert J. Matusik
Summary: The study found elevated levels of prostaglandins in the prostate tissue of patients who required surgery to relieve BPH/LUTS symptoms, indicating potential reasons for failure in medical therapy.
Article
Physiology
Hannah M. Ruetten, Gervaise H. Henry, Teresa T. Liu, Heidi M. Spratt, William A. Ricke, Douglas W. Strand, Chad M. Vezina
Summary: The void spot assay is a cost-effective method for evaluating and quantifying mouse urinary voiding phenotypes. It can differentiate voiding behaviors between different experimental groups and accurately classify mice based on voiding dysfunction etiology. The approach of using principal components analysis and hierarchical clustering can help identify specific urinary phenotypes in mice.
PHYSIOLOGICAL REPORTS
(2021)
Article
Biochemical Research Methods
Christopher Bennett, Micah Thornton, Chanhee Park, Gervaise Henry, Yun Zhang, Venkat Malladi, Daehwan Kim
Summary: SeqWho is a program that accurately and rapidly classifies sequencing files by analyzing their characteristics, providing reliable identification of the organism and protocol type.
Article
Oncology
Diya B. Joseph, Gervaise H. Henry, Alicia Malewska, Jeffrey C. Reese, Ryan J. Mauck, Jeffrey C. Gahan, Ryan C. Hutchinson, James L. Mohler, Claus G. Roehrborn, Douglas W. Strand
Summary: Benign prostatic hyperplasia (BPH) is a common condition in aging men, treated with 5-alpha reductase inhibitors (SARI) to reduce prostate volume and improve lower urinary tract symptoms. However, the histologic response to SARI treatment is heterogeneous, with potential need for surgical intervention.
JOURNAL OF PATHOLOGY
(2022)
Article
Endocrinology & Metabolism
Liwei Jia, Douglas W. Strand, Ramy S. Goueli, Jeffrey C. Gahan, Claus G. Roehrborn, Ryan J. Mauck
Summary: The study suggests that using PSA density could help estimate BPH cellular content, leading to improved selection of patients for treatment, especially for 5ARI therapy.
Article
Endocrinology & Metabolism
Renjie Jin, Connor Forbes, Nicole L. Miller, Douglas Strand, Thomas Case, Justin M. Cates, Hye-Young H. Kim, Phillip Wages, Ned A. Porter, Krystin M. Mantione, Sarah Burke, James L. Mohler, Robert J. Matusik
Summary: This study characterized the pathways associated with failure of medical therapy for BPH/LUTS. It found that 5-alpha reductase inhibitor (5ARI) therapy continued to inhibit androgenesis, but also increased tissue levels of glucocorticoids (GC). This GC activation served as a master regulator of prostatic branching and growth.
Article
Oncology
Jiapei Yuan, Kathleen E. Houlahan, Susmita G. Ramanand, Sora Lee, GuemHee Baek, Yang Yang, Yong Chen, Douglas W. Strand, Michael Q. Zhang, Paul C. Boutros, Ram S. Mani
Summary: Prostate cancer is highly heritable and researchers have identified multiple risk alleles associated with the disease. This study used three-dimensional spatial genomics to identify the target genes regulated by these risk alleles in prostate tumors. The findings revealed the complex regulation of these genes and their interactions with different tumor types.