Article
Cardiac & Cardiovascular Systems
Melinda Wu, Joshua J. Fields, Vandana Sachdev, Todd Belcik, Junmei Chen, Franklin Reed, Xiaoyun Fu, James Hodovan, Leanne M. Harmann, Gabriella Swistara, Jonathan R. Lindner
Summary: This study characterized the pain-related adverse events (AEs) caused by ultrasound enhancing agents (UEAs) in patients with sickle cell disease (SCD) and investigated the potential mechanisms. The results showed that the pain caused by UEAs is mainly due to the reaction between UEAs and the patient's immune system, and is not directly related to vaso-occlusive crisis (VOC) caused by UEAs.
JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Pankaj Gupta, Pratyaksha Rana, Yashi Marodia, Jayanta Samanta, Vishal Sharma, Saroj K. Sinha, Harjeet Singh, Vikas Gupta, Thakur Deen Yadav, Radhika Sreenivasan, Kim Vaiphei, Arvind Rajwanshi, Rakesh Kochhar, Manavjit Sandhu
Summary: Contrast-enhanced ultrasound (CEUS) plays an important role in the evaluation of solid pancreatic head lesions (SPHL) and can be used to differentiate pancreatic ductal adenocarcinoma (PDAC) from non-PDAC lesions.
EUROPEAN RADIOLOGY
(2022)
Article
Pediatrics
Susan J. Back, Patricia T. Acharya, Richard D. Bellah, Harris L. Cohen, Kassa Darge, Annamaria Deganello, Zoltan Harkanyi, Damjana Kljucevsek, Aikaterini Ntoulia, Harriet J. Paltiel, Maciej Piskunowicz
Summary: The pediatric applications of CEUS for kidneys and adrenal glands are expanding, with a focus on evaluating ischemic disorders, tumor differentiation, cystic lesions, pyelonephritis, and trauma. The use of CEUS in children remains off-label for intravenous administration of US contrast agents but shows potential for clinical utilization by extrapolating adult kidney evaluation knowledge to the pediatric context.
PEDIATRIC RADIOLOGY
(2021)
Article
Pediatrics
Cheng Fang, Sudha A. Anupindi, Susan J. Back, Doris Franke, Thomas G. Green, Zoltan Harkanyi, Jorg Jungert, Jeannie K. Kwon, Harriet J. Paltiel, Judy H. Squires, Vassil N. Zefov, M. Beth McCarville
Summary: Contrast-enhanced ultrasound (CEUS) is increasingly used in children for characterization and follow-up of liver lesions. It involves intravenous administration of ultrasound contrast agents for real-time observation of enhancement patterns, often providing definite diagnosis and avoiding the need for further imaging or procedures. The recent approval of Lumason for pediatric liver CEUS applications has contributed to the widespread use of CEUS.
PEDIATRIC RADIOLOGY
(2021)
Article
Pediatrics
Maciej Piskunowicz, Susan J. Back, Kassa Darge, Paul D. Humphries, Joerg Juengert, Damjana Kljucevsek, Norbert Lorenz, Hans-Joachim Mentzel, Judy H. Squires, Dean Y. Huang
Summary: CEUS is currently limited to liver and heart imaging in pediatric and adult populations, but has great potential for imaging small organs like the thyroid gland, lymph nodes, testes, ovaries, and uterus. While studies in adults have shown the utility of CEUS for evaluating these small organs, there is still untapped potential for its application in children based on adult literature.
PEDIATRIC RADIOLOGY
(2021)
Article
Pediatrics
Ryne A. Didier, David M. Biko, Misun Hwang, Sunil Unnikrishnan, Magdalena M. Wozniak, Gibran T. Yusuf, Anush Sridharan
Summary: The use of ultrasound contrast agent in radiology is expanding beyond traditional applications, with emerging techniques such as 3-D and 4-D contrast-enhanced ultrasound imaging showing potential in improving accuracy in voiding urosonography and assisting in tumor resection. There is also active research and early clinical translation in targeted US molecular imaging. Additionally, a new exciting development involves the use of UCA for localized drug delivery and release in the treatment of aggressive brain tumors.
PEDIATRIC RADIOLOGY
(2021)
Article
Pediatrics
Doris Franke, Reza J. Daugherty, Damjana Kljucevsek, Aikaterini Ntoulia, Vasileios Rafailidis, Marcelo S. Takahashi, Alvaro Torres, Bernarda Viteri, Frank M. Volberg
Summary: Ultrasound, especially contrast-enhanced ultrasound (CEUS), plays a crucial role in evaluating liver and kidney transplants by assessing organ status, vascular patency, and potential complications, aiding in prompt and accurate diagnosis for management decisions. It is particularly useful for detecting vascular complications, parenchymal abnormalities, and excluding underlying causes for organ dysfunction suspected of transplant rejection.
PEDIATRIC RADIOLOGY
(2021)
Article
Pediatrics
Doris Franke, Sudha A. Anupindi, Carol E. Barnewolt, Thomas G. Green, Mary-Louise C. Greer, Zoltan Harkanyi, Norbert Lorenz, M. Beth McCarville, Hans-Joachim Mentzel, Aikaterini Ntoulia, Judy H. Squires
Summary: This manuscript provides an overview of the applications of contrast-enhanced ultrasound (CEUS) for normal variants and diseases affecting the spleen, gallbladder, and pancreas in children. It highlights how CEUS can serve in the diagnosis and follow-up for such diseases in children with specific examination techniques and presentation of main imaging findings in various benign and malignant lesions. The limitations of CEUS for these organs are also acknowledged.
PEDIATRIC RADIOLOGY
(2021)
Article
Acoustics
Mawia Khairalseed, Kenneth Hoyt
Summary: A generalized mathematical framework called pulse inversion spectral deconvolution (PISD) for contrast-enhanced ultrasound (CEUS) imaging is introduced in this article. The PISD approach is based on Gaussian derivative functions (GDFs) and uses PISD pulses to filter backscattered ultrasound (US) data for isolating nonlinear (NL) microbubble (MB) signals. The study evaluates the role of wide-beam transmit aperture size in CEUS imaging and quantifies image enhancement using a contrast-to-noise ratio (CNR). In vivo data collected in rats demonstrates that PISD-based CEUS imaging improves vascular visualization compared to the NL imaging strategy.
Review
Pediatrics
Aikaterini Ntoulia, Sudha A. Anupindi, Susan J. Back, Ryne A. Didier, Misun Hwang, Ann M. Johnson, M. Beth McCarville, Frederica Papadopoulou, Maciej Piskunowicz, Maria E. Sellars, Kassa Darge
Summary: Research has shown that adverse reactions in pediatric CEUS use are mainly non-serious, with a very small number of children experiencing allergic reactions. In studies involving intravenous CEUS, the rate of serious adverse events is low, while the rate of non-serious adverse events is slightly higher. Adverse events caused by the use of UCA in the bladder are mostly related to bladder catheters rather than the UCA itself.
PEDIATRIC RADIOLOGY
(2021)
Article
Pediatrics
Harriet J. Paltiel, Richard A. Barth, Costanza Bruno, Aaron E. Chen, Annamaria Deganello, Zoltan Harkanyi, M. Katherine Henry, Damjana Kljucevsek, Susan J. Back
Summary: Trauma is a major cause of morbidity and mortality in children, with rapid identification of organ injury being crucial for successful treatment. Contrast-enhanced ultrasound (CEUS) is a beneficial alternative to contrast-enhanced CT in evaluating blunt abdominal trauma in children, particularly in reducing radiation exposure. CEUS is effective in diagnosing solid organ injuries and detecting abnormalities that may not be visible on conventional ultrasound.
PEDIATRIC RADIOLOGY
(2021)
Article
Acoustics
Sean Mcgrath, Yu-Jack Shen, Masato Aragaki, Yamato Motooka, Takamasa Koga, Alexander Gregor, Nicholas Bernards, Emmanuel Cherin, Christine E. M. Demore, Kazuhiro Yasufuku, Naomi Matsuura
Summary: This study assessed the imaging ability of CE-EBUS in vitro and in vivo and found that CE-EBUS can produce contrast imaging comparable to commercial pre-clinical and clinical ultrasound systems. CE-EBUS has the potential for clinical characterization of mediastinal lymph nodes in lung cancer patients.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2024)
Article
Acoustics
Qiuyang Li, Kaixiu Yang, Yongjiao Ji, Hongrui Liu, Xiang Fei, Yan Zhang, Jingbo Li, Yukun Luo
Summary: This study assessed the incidence of adverse events (AEs) in a large cohort of patients who underwent contrast-enhanced ultrasound (CEUS) with Lumason/SonoVue. The study found a low incidence of AEs, most of which were mild and had a short duration.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2023)
Article
Pediatrics
Aikaterini Ntoulia, Carol E. Barnewolt, Andrea S. Doria, Victor M. Ho-Fung, Norbert Lorenz, Hans-Joachim Mentzel, Susan J. Back
Summary: The use of CEUS in musculoskeletal applications has expanded in both adults and children, with various applications such as detecting inflammatory joint diseases, imaging muscle and tendon perfusion, evaluating malignant potential of soft-tissue masses, and aiding in the diagnosis and treatment of pediatric hip diseases. Quantitative CEUS measurements of blood flow imaging parameters are crucial for monitoring treatment outcomes.
PEDIATRIC RADIOLOGY
(2021)
Review
Radiology, Nuclear Medicine & Medical Imaging
Judy H. Squires, M. Beth McCarville
Summary: The utilization of CEUS in children is rapidly expanding, offering several advantages such as dynamic evaluation of vascular structures and lack of ionizing radiation. UCAs used intravenously in children have been shown to have excellent safety profiles, with potential off-label applications expanding diagnostic possibilities. CEUS is commonly used for focal liver lesion evaluation, and has potential alternative applications like evaluation of blunt abdominal trauma in hemodynamically stable children. Additional potential applications in various organs require further study.
AMERICAN JOURNAL OF ROENTGENOLOGY
(2021)
