Article
Medicine, General & Internal
Feyza Memis, Carlijn G. E. Thijssen, Arjen L. Gokalp, Maximiliaan L. Notenboom, Frederike Meccanici, Mohammad Mostafa Mokhles, Roland R. J. van Kimmenade, Kevin M. Veen, Guillaume S. C. Geuzebroek, Jelena Sjatskig, Franciscus J. ter Woorst, Jos A. Bekkers, Johanna J. M. Takkenberg, Jolien W. Roos-Hesselink
Summary: This study aims to evaluate patient and procedural characteristics and compare the outcomes and mortality after surgery between elderly and non-elderly patients with ascending aortic aneurysm. The study found that elderly patients had larger aortic diameters and more cardiovascular risk factors. Short-term mortality was comparable between elderly and non-elderly patients, but the five-year survival rate was lower in elderly patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Genetics & Heredity
David Freiholtz, Otto Bergman, Sailendra Pradhananga, Karin Lang, Flore-Anne Poujade, Carl Granath, Christian Olsson, Anders Franco-Cereceda, Pelin Sahlen, Per Eriksson, Hanna M. Bjorck
Summary: The fibrotic type of endothelial mesenchymal transition (EndMT) is implicated in the development of degenerative ascending aortic aneurysm (AscAA). This study identified SPP1 as a key gene in the signature of fibrotic EndMT in patients with degenerative AscAA. The study also implicated ETS1 as a potential regulator of SPP1 expression under inflammatory conditions.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2023)
Article
Biochemistry & Molecular Biology
Antonio Tejera-Munoz, Isabel Rodriguez, Alvaro Del Rio-Garcia, Yamina Mohamedi, Maria Martin, Valentina Chiminazzo, Beatriz Suarez-Alvarez, Carlos Lopez-Larrea, Marta Ruiz-Ortega, Raul R. Rodrigues-Diez
Summary: The study found an association between the C allele of rs12526196 in the CCN2 gene and the presence of thoracic aortic aneurysm (TAA), suggesting a potential protective role of CCN2 in TAA development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cardiac & Cardiovascular Systems
Anum S. Minhas, Wendy S. Post, Bin Liu, Henrique Doria De Vasconcellos, Sabina A. Haberlen, Matthew Feinstein, Valentina Stosor, Matthew Budoff, Kara W. Chew, Jared W. Magnani, Todd Brown, Joao A. C. Lima, Katherine C. Wu
Summary: This study examined the association between HIV infection and aortic sizes in individuals living with HIV. It found that HIV infection was associated with larger aortic root and ascending aorta sizes. Lower CD4 T-cell count and higher levels of TNF-alpha were also found to be associated with larger aortic sizes in men with HIV.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Chemistry, Multidisciplinary
Joe F. Juffermans, Hans C. van Assen, Bastiaan J. C. te Kiefte, Mitch J. F. G. Ramaekers, Roel L. F. van der Palen, Pieter van den Boogaard, Bouke P. Adriaans, Joachim E. Wildberger, Ilona A. Dekkers, Arthur J. H. A. Scholte, Simon Schalla, Hildo J. Lamb, Jos J. M. Westenberg
Summary: This study evaluated the reproducibility of 4D flow MRI-derived hemodynamic parameters in the thoracic aorta of patients with thoracic aortic aneurysm (TAA). The results showed good to excellent reproducibility for parameters such as normalized flow displacement, flow jet angle, wall shear stress, vorticity, and helicity. These parameters can be used to assess aortic aneurysms.
APPLIED SCIENCES-BASEL
(2022)
Article
Hematology
John DePaolo, Michael G. Levin, Catherine Tcheandjieu, James R. Priest, Dipender Gill, Stephen Burgess, Scott M. Damrauer, Julio A. Chirinos
Summary: Observational studies have shown that high blood pressure is a significant risk factor for thoracic aortic dilation, and reducing blood pressure is recommended for preventing the progression of aortic aneurysms. However, the causal relationship between blood pressure and aortic size has not been conclusively established.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Article
Medicine, General & Internal
Nerea Lopez Perez, Philippe Reymond, Mustafa Cikirikcioglu, Mathieu van Steenberghe, Tornike Sologashvili, Nicolas Murith, Thomas Perneger, Christoph Huber
Summary: This study examines the ratio between ascending and descending aorta diameters as a potential surrogate marker for decision making in cases of ascending aortic dilatation. A retrospective observational cohort study was conducted on 50 patients who underwent surgery for acute type A aorta dissection. The results suggest that the ratio between descending and ascending aorta diameters may be a useful tool for stratifying the risk of dissection.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Kaitlin M. Marquis, Muhammad Naeem, Mohamed Zak Rajput, Demetrios A. Raptis, Kacie L. Steinbrecher, J. Westley Ohman, Sanjeev Bhalla, Constantine A. Raptis
Summary: The management of ascending aorta and aortic arch repairs has become more complex with the implementation of newer open surgical and endovascular techniques. It is important for diagnostic radiologists to focus on key questions related to repair components, including aortic valve and sinuses repair for ascending aorta repairs, and arch vessels management for aortic arch repairs. Understanding these questions will facilitate the interpretation of CT studies and identification of complications in postoperative imaging appearances.
Article
Medicine, General & Internal
Angela Lopez, Ilaria Dentamaro, Laura Galian, Francisco Calvo, Josep M. Alegret, Violeta Sanchez, Rodolfo Citro, Antonella Moreo, Fabio Chirillo, Paolo Colonna, Maria Celeste Carrero, Eduardo Bossone, Sergio Moral, Augusto Sao-Aviles, Laura Gutierrez, Gisela Teixido-Tura, Jose Rodriguez-Palomares, Arturo Evangelista
Summary: The study aimed to assess the progression of aortic dilation and valve dysfunction in BAV patients. Results showed that rapid aortic root dilation was associated with male sex, hypertension, presence of raphe, and aortic regurgitation, while rapid ascending aorta dilation was only related to hypertension.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Mitch J. F. G. Ramaekers, Bouke P. Adriaans, Joe F. Juffermans, Hans C. van Assen, Sebastiaan C. A. M. Bekkers, Arthur J. H. A. Scholte, Sasa Kenjeres, Hildo J. Lamb, Joachim E. Wildberger, Jos J. M. Westenberg, Simon Schalla
Summary: The study found that patients with degenerative TAA have decreased flow vorticity and helicity, which may cause disturbances in physiological flow patterns. This altered distribution of wall shear stress could potentially be a contributing factor to vessel wall remodeling and aneurysm formation.
INVESTIGATIVE RADIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Paris D. Kalogerakos, Mohammad A. Zafar, Yupeng Li, Sandip K. Mukherjee, Bulat A. Ziganshin, John A. Rizzo, John A. Elefteriades
Summary: This study suggests that there are unique differences in the natural histories of the aortic root and mid-ascending aorta. Aortic root dilatation poses a significantly higher risk of adverse events compared to mid-ascending aortic dilatation. Therefore, expert centers may consider shifting the diameter criteria for intervention to 5.0 cm for the aortic root and 5.25 cm for the mid-ascending aorta.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Physiology
Leonardo Geronzi, Pascal Haigron, Antonio Martinez, Kexin Yan, Michel Rochette, Aline Bel-Brunon, Jean Porterie, Siyu Lin, Diana Marcela Marin-Castrillon, Alain Lalande, Olivier Bouchot, Morgan Daniel, Pierre Escrig, Jacques Tomasi, Pier Paolo Valentini, Marco Evangelos Biancolini
Summary: The current guidelines for the treatment of ascending aortic aneurysm (AsAA) recommend surgery based on maximum diameter assessment, which is often inefficient in identifying high-risk patients. This study proposes a method to compute a set of local shape features, in addition to the maximum diameter, to improve the classification performance for assessing aneurysm growth risk. The results show that the classifiers based on the shape features outperformed those based only on diameter.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Medicine, General & Internal
Tomasz Plonek, Bartosz Rylski, Pawel Nawrocki, Friedhelm Beyersdorf, Marek Jasinski, Wiktor Kuliczkowski
Summary: The study demonstrates a negative correlation between systolic aortic stretching and patient age and the diameter of the tubular ascending aorta, but not with the diameter of the aortic root. Additionally, systolic aortic stretching values were lower in patients with aortic valve pathology.
ARCHIVES OF MEDICAL SCIENCE
(2021)
Article
Cardiac & Cardiovascular Systems
Ruchika Meel, Michael Hasenkam, Ricardo Goncalves, Kelly Blair, Shungu Mogaladi
Summary: This study describes the spectrum of thoracic ascending aortic (TAA) aneurysms at a peri-urban tertiary hospital. It found that TAA aneurysms are commonly associated with hypertension and HIV infection and are associated with significant morbidity and mortality. Two-dimensional echocardiography and advanced strain imaging can be potential tools for detecting and risk stratifying TAA aneurysms.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Ignas B. Houben, Angel K. Y. Chu, Bo Yang, Karen M. Kim, Shinichi Fukuhara, Joost A. van Herwaarden, Frans L. Moll, David A. Nordsletten, C. Alberto Figueroa, Nicholas S. Burris, Himanshu J. Patel
Summary: Proximal aortic repair with stiff polyester grafts may lead to increased left ventricular mass in the first year post-operative, promoting long-term adverse cardiac remodeling. Surgery, baseline LVMI, age, and sex were identified as independent predictors of increased LVMI.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
