Predicting neuropsychological late effects in pediatric brain tumor survivors using the Neurological Predictor Scale and the Pediatric Neuro-Oncology Rating of Treatment Intensity

Objective: The Neurological Predictor Scale (NPS) quantifies cumulative exposure to tumor-and treatment-related neurological risks. The Pediatric Neuro-Oncology Rating of Treatment Intensity (PNORTI) measures the intensity of different treatment modalities, but research is needed to establish whether it is associated with late effects. This study evaluated the predictive validity of the NPS and PNORTI for neuropsychological outcomes in pediatric brain tumor survivors. Method: A retrospective chart review was completed of pediatric brain tumor survivors (PBTS) (n = 161, M-age = 13.47, SD = 2.80) who were at least 2 years from the end of tumor-directed treatment. Attention, intellectual functioning, perceptual reasoning, processing speed, verbal reasoning, and working memory were analyzed in relation to the NPS and PNORTI. Results: NPS scores ranged from 1 to 11 (M = 5.57, SD = 2.27) and PNORTI scores ranged from 1 (n = 101; 62.7%) to 3 (n = 18; 11.2%). When controlling for age, sex, SES factors, and time since treatment, NPS scores significantly predicted intellectual functioning [F(7,149)= 12.86, p < .001, R-2 = .38] and processing speed [F(7,84) = 5.28, p < .001, R-2 = .31]. PNORTI scores did not significantly predict neuropsychological outcomes. Conclusions: The findings suggest that the NPS has value in predicting IF and processing speed above-and-beyond demographic variables. The PNORTI was not associated with neuropsychological outcomes. Future research should consider establishing clinical cutoff scores for the NPS to help determine which survivors are most at risk for neuropsychological late effects and warrant additional assessment.

Automated summary

This study evaluated the predictive validity of the Neurological Predictor Scale (NPS) and Pediatric Neuro-Oncology Rating of Treatment Intensity (PNORTI) for neuropsychological outcomes in pediatric brain tumor survivors. The findings suggest that the NPS has value in predicting intellectual functioning and processing speed, while the PNORTI is not associated with neuropsychological outcomes. Future research should consider establishing clinical cutoff scores for the NPS to help determine the need for additional assessment.