Article
Chemistry, Multidisciplinary
Hidenori Ando, Ai Ikeda, Maho Tagami, Nana Cristina Amorim Matsuo, Taro Shimizu, Yu Ishima, Kiyoshi Eshima, Tatsuhiro Ishida
Summary: The pH of the tumor microenvironment affects the efficacy of anticancer drugs, and oral administration of sodium bicarbonate can neutralize the acidity and enhance the effects of these drugs.
JOURNAL OF CONTROLLED RELEASE
(2022)
Review
Chemistry, Multidisciplinary
Yue Wang, Xueer Zhou, Wenxuan Wang, Yongyao Wu, Zhiyong Qian, Qiang Peng
Summary: Cancer poses a serious threat to humans, and traditional therapies may not be sufficient for the increasing demands of patients. NaHCO3 has been found to potentially treat cancer by reversing the acidic tumor microenvironment.
CHINESE CHEMICAL LETTERS
(2021)
Review
Oncology
Lars M. Schiffmann, Christiane J. Bruns, Thomas Schmidt
Summary: Anti-angiogenic therapies have not met expectations in clinical trials, as patients develop resistance. Understanding resistance mechanisms is crucial for improving treatment efficacy.
FRONTIERS IN ONCOLOGY
(2022)
Review
Immunology
Kexun Zhou, Shuo Li, Yi Zhao, Ke Cheng
Summary: Immune checkpoint inhibitors (ICIs) have shown great promise in prolonging the survival of patients with advanced non-small cell lung cancer (NSCLC). However, resistance to ICIs remains a challenge, with different mechanisms and tumor microenvironment playing a critical role.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Heng Wang, Beilei Wang, Jie Jiang, Yi Wu, Anning Song, Xiaoyu Wang, Chenlu Yao, Huaxing Dai, Jialu Xu, Yue Zhang, Qingle Ma, Fang Xu, Ruibin Li, Chao Wang
Summary: The SnSe nanozymes can degrade lactate to pyruvate, reducing tumor acidity and activating T cell immune responses, thereby alleviating the immunosuppressive environment. Additionally, the nanozymes effectively inhibit tumor growth.
Review
Chemistry, Multidisciplinary
Mehdi Rahmanian, Amir Seyfoori, Mohsen Ghasemi, Milad Shamsi, Ahmad Rezaei Kolahchi, Hassan Pezeshgi Modarres, Amir Sanati-Nezhad, Keivan Majidzadeh-A
Summary: The complexity and heterogeneity of the 3D tumor microenvironment pose challenges to tumor studies and treatment. Traditional tumor models are limited in simulating resistance mechanisms, while new technologies have potential for simulating the 3D tumor microenvironment and identifying mechanisms underlying multidrug resistance.
JOURNAL OF CONTROLLED RELEASE
(2021)
Review
Oncology
Dorina Belotti, Denise Pinessi, Giulia Taraboletti
Summary: Tumors rely on blood vessels for growth and metastasis. Different mechanisms of tumor vessel formation have a significant impact on tumor response to therapies, with strategies targeting tumor vasculature showing promise in overcoming drug resistance and improving treatment efficacy.
Review
Medicine, Research & Experimental
Xinming Li, Mingdong Li, Meiying Huang, Qianyi Lin, Qiuping Fang, Jianjiang Liu, Xiaohui Chen, Lin Liu, Xuliang Zhan, Huisi Shan, Deshuai Lu, Qinlan Li, Zesong Li, Xiao Zhu
Summary: Cancer drug therapy is still dominated by chemotherapy drugs, but drug resistance remains a challenging problem. The emergence of targeted drugs has improved patient survival rate, but drug resistance is still prevalent. The development of gene detection, liquid biopsy ctDNA technology, and single-cell sequencing technology has shed light on the molecular mechanisms of tumor drug resistance, allowing for the exploration of new approaches to overcome drug resistance.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Biochemistry & Molecular Biology
Hsiang-Hao Chuang, Yen-Yi Zhen, Yu-Chen Tsai, Cheng-Hao Chuang, Michael Hsiao, Ming-Shyan Huang, Chih-Jen Yang
Summary: In this review, the authors summarize the mechanisms of FAK-mediated signaling networks during tumor development and the recent progress of FAK-targeted small-molecule compounds for anticancer activity from preclinical and clinical evidence.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Immunology
Yiwen Zheng, Shujin Li, Hongchao Tang, Xuli Meng, Qinghui Zheng
Summary: The emergence of immunotherapy has revolutionized the treatment of triple-negative breast cancer (TNBC). However, the heterogeneity of TNBC leads to varying efficacy of immunotherapy, with only certain patients benefiting from it. This article focuses on the mechanisms of immune response and summarizes the immune evasion mechanisms in TNBC, including loss of tumor-specific antigen, antigen presentation deficiency, and failure to initiate an immune response. Moreover, the aberrant activation of immune-critical signaling pathways contributes to an immunosuppressive tumor microenvironment. The review aims to elucidate the molecular mechanisms of drug resistance in TNBC, identify potential targets to reverse drug resistance, and lay a foundation for biomarker research to predict immune efficacy and select breast cancer populations for immunotherapy.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cell Biology
Erbao Chen, Yuqian Mo, Jing Yi, Jie Liu, Ting Luo, Zheng Li, Zewei Lin, Yibing Hu, Zhilin Zou, Jikui Liu
Summary: The mTORC1 pathway plays a significant role in tumor oncogenesis, cancer metastasis, and immune evasion. This study identified a gene signature and score based on mTORC1 signaling, which can predict the overall survival and immunotherapeutic outcomes for hepatocellular carcinoma (HCC) patients, and guide the development of personalized immunotherapy protocols.
Article
Oncology
Jay Natu, Ganji Purnachandra Nagaraju
Summary: Pancreatic ductal adenocarcinoma (PDAC) is a deadly malignancy with high chemoresistance. Gemcitabine, one of the primary treatments for PDAC, has limited benefits due to interactions with the tumor microenvironment (TME). Preclinical models have shown that certain schedules of gemcitabine administration can modulate the TME without promoting resistance. Metronomic therapy is a promising strategy to overcome barriers in PDAC treatments.
Review
Oncology
Ann Hanna, Justin M. Balko
Summary: Immunotherapy has revolutionized cancer treatment by targeting the immune system, yet resistance to immune checkpoint blockade poses challenges in breast cancer treatment. Heterogeneous responses to ICB in different tumors highlight the need for further research in understanding and overcoming resistance mechanisms in breast cancer to improve patient outcomes.
BREAST CANCER RESEARCH AND TREATMENT
(2021)
Article
Cell Biology
Xia Meng, Yurui Xu, Xinghai Ning
Summary: Research shows that acidic conditions enhance the migration and invasion abilities of hepatocellular carcinoma cells, promoting tumor metastasis by modulating ROR1 expression. Neutralizing acidic environments with NaHCO3 can inhibit this process.
JOURNAL OF CELL SCIENCE
(2021)
Review
Pharmacology & Pharmacy
Chunlan Zhang, Leiming Wang, Caigang Xu, Heng Xu, Yu Wu
Summary: Immune checkpoint inhibitors have greatly improved the treatment options for lymphoma, but their efficacy varies among different subtypes. Understanding the mechanisms of resistance to ICIs is crucial for optimizing individualized regimens. Recent studies have identified potential prognostic factors such as tumor mutation burden and tumor microenvironment. This review focuses on the role of the tumor microenvironment in lymphoma and its impact on ICI sensitivity, as well as highlighting potential biomarkers and targets for immunotherapy.
FRONTIERS IN PHARMACOLOGY
(2023)
Editorial Material
Medicine, General & Internal
David Martin, Nicolas Demartines, Martin Huebner
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Oncology
David Martin, Yael Maeder, Kosuke Kobayashi, Michael Schneider, Joachim Koerfer, Emmanuel Melloul, Nermin Halkic, Martin Hubner, Nicolas Demartines, Fabio Becce, Emilie Uldry
Summary: This study evaluated the association between preoperative sarcopenia assessed by CT imaging and postoperative clinical outcomes and overall survival in liver resection patients. The results showed that preoperative sarcopenia, based on CT assessment alone, had no impact on postoperative clinical outcomes or overall survival. Future research should consider comprehensive assessment of muscle strength and physical performance for preoperative risk stratification.
Review
Oncology
Hugo Teixeira Farinha, Antonia Digklia, Dimitrios Schizas, Nicolas Demartines, Markus Schaefer, Styliani Mantziari
Summary: This review discusses the rationale for immunotherapy in different stages of esophageal cancer treatment and provides an overview of ongoing clinical trials and novel targeted agents. Immunotherapy shows promise in the early treatment of esophageal cancer, and new approaches are being developed.
Review
Biochemistry & Molecular Biology
Benedetta Cena, Emmanuel Melloul, Nicolas Demartines, Olivier Dormond, Ismail Labgaa
Summary: The molecular analysis of circulating analytes, known as liquid biopsy, has shown great potential in cancer management. However, there is a lack of data on liquid biopsy in basic research. This report reviews the available data on liquid biopsy, highlighting its importance in understanding the biology of analyte release.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Nutrition & Dietetics
Mohamed A. Abd-El-Aziz, Martin Hubner, Nicolas Demartines, David W. Larson, Fabian Grass
Summary: The present large scale study aimed to assess the prevalence and consequences of malnutrition in surgical IBD patients in the US. The study found that the true prevalence of malnutrition was greatly underestimated when only using clinical assessment based on BMI and weight loss. Patients with malnutrition had higher rates of complications, longer hospital stays, and higher mortality rates.
Article
Medicine, General & Internal
Patricia Dias, Daniel Clerc, Maria Goreti da Rocha Rodrigues, Nicolas Demartines, Fabian Grass, Martin Huebner
Summary: This study suggests that a preoperative nurse dialogue can help reduce preoperative anxiety in patients undergoing major visceral surgery.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Oncology
Sergio Gaspar-Figueiredo, Pierre Allemann, Alexander B. J. Borgstein, Gaetan-Romain Joliat, Valentine Luzuy-Guarnero, Christophe Brunel, Christine Sempoux, Suzanne Sarah Gisbertz, Nicolas Demartines, Mark Ivo van Berge Henegouwen, Markus Schafer, Styliani Mantziari
Summary: This study aimed to assess the prognostic value of microscopically positive margins (R1) after gastrectomy on survival and tumor recurrence in diffuse-type gastric cancer (DTGC) patients. It showed that patients with R1 had poorer overall survival and disease-free survival, as well as higher early tumor recurrence rates. Therefore, achieving R0 resection should be pursued whenever possible.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Cell Biology
Cansaran Saygili Demir, Amelie Sabine, Muyun Gong, Olivier Dormond, Tatiana V. V. Petrova
Summary: In this study, the dynamics and molecular mechanisms of lymphatic endothelial cell (LEC) renewal in adult mesenteric lymphatic vessels were investigated. It was found that adult LEC turnover and proliferation were limited to the valve regions of collecting vessels, with valve cells having the shortest lifespan. Proliferating valve sinus LECs were identified as the main source for maintenance and repair of lymphatic valves. Mechanistic target of rapamycin complex 1 (mTORC1) was identified as a mechanoresponsive pathway activated by fluid shear stress in LECs, driving valve cell division or dictating their mechanic resilience through increased protein synthesis. Overactivation of lymphatic mTORC1 in vivo promoted supernumerary valve formation.
JOURNAL OF CELL BIOLOGY
(2023)
Review
Medicine, General & Internal
David Martin, Piero Alberti, Nicolas Demartines, Melanie Phillips, John Casey, Andrew Sutherland
Summary: Whole-organ pancreas and islets transplantations are therapeutic options for type 1 diabetic patients with severe complications. The choice of treatment depends on factors such as kidney function, comorbidities, and treatment goals. Simultaneous pancreas and kidney transplant is often recommended for patients with end-stage kidney disease, but careful selection is necessary. New strategies, including dynamic organ perfusion technologies and stem cell therapies, aim to improve outcomes and reduce immune reactions. This article reviews the indications, surgical techniques, outcomes, and future directions of these transplantations.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Oncology
Styliani Mantziari, Penelope St Amour, Francesco Abboretti, Hugo Teixeira-Farinha, Sergio Gaspar Figueiredo, Caroline Gronnier, Dimitrios Schizas, Nicolas Demartines, Markus Schafer
Summary: Despite recent therapeutical advances, gastric adenocarcinoma remains associated with a poor long-term survival. Diagnosis is often made at advanced stages, affecting prognosis. Factors such as tumor microenvironment, patient ethnicity, and therapeutic strategy play a role in patient outcome. This study aims to review existing knowledge on prognostic factors in gastric adenocarcinoma.
Article
Surgery
Philip Deslarzes, Jonas Jurt, Martin Hubner, Dieter Hahnloser, Daniel Clerc, Laurence Senn, Nicolas Demartines, Fabian Grass
Review
Medicine, General & Internal
David Martin, Piero Alberti, Stephen J. Wigmore, Nicolas Demartines, Gaetan-Romain Joliat
Summary: Pancreatic cancer is a deadly disease with unknown origins and limited treatment options. Surgical resection, the primary curative treatment, is associated with high morbidity and mortality rates and frequent recurrence. Patient-centered care and understanding patient perspectives are crucial for improving outcomes in pancreatic cancer surgery. Standardized patient-reported outcome and experience measures are needed to assess patient perspectives accurately.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Elisa Reitano, Simone Famularo, Bernard Dallemagne, Kohei Mishima, Silvana Perretta, Pietro Riva, Pietro Addeo, Horacio J. Asbun, Claudius Conrad, Nicolas Demartines, David Fuks, Mariano Gimenez, Melissa E. Hogg, Charles Chung-Wei Lin, Jacques Marescaux, John B. Martinie, Riccardo Memeo, Olivier Soubrane, Michel Vix, Xiaoying Wang, Didier Mutter
Summary: This study aims to create a scoring system to calculate the learning curve of laparoscopic cholecystectomy (LC) based on the opinions of hepatobiliopancreatic (HPB) experts. Variables were selected through a questionnaire and ranked by experts. The scoring system can be used to assess the efficacy of LC within educational programs and surgical courses.
MEDICINA-LITHUANIA
(2023)
Article
Surgery
Maximilien Ravenel, Gaetan-Romain Joliat, Nicolas Demartines, Emilie Uldry, Emmanuel Melloul, Ismail Labgaa
BRITISH JOURNAL OF SURGERY
(2023)
Review
Surgery
Didier Roulin, Nicolas Demartines
Summary: This article assesses the current evidence on perioperative management in gastrointestinal surgery, focusing on the impact of surgery-related aspects, the benefits of outcomes, and future directions. It emphasizes the need for continuous improvement in patients' compliance with ERAS to ensure optimal perioperative care. In addition, clinical practice should be based on the latest evidence-based medicine and challenge conventional surgical practices. Surgeons should also lead and support multidisciplinary and collaborative teamwork especially with anesthetists and nursing staff.
LANGENBECKS ARCHIVES OF SURGERY
(2022)