Article
Health Care Sciences & Services
I-Wen Wu, Tsung-Hsien Tsai, Chi-Jen Lo, Yi-Ju Chou, Chi-Hsiao Yeh, Yun-Hsuan Chan, Jun-Hong Chen, Paul Wei-Che Hsu, Heng-Chih Pan, Heng-Jung Hsu, Chun-Yu Chen, Chin-Chan Lee, Yu-Chiau Shyu, Chih-Lang Lin, Mei-Ling Cheng, Chi-Chun Lai, Huey-Kang Sytwu, Ting-Fen Tsai
Summary: AI-assisted models using machine learning algorithms were developed to identify biomarker signatures for diabetic kidney disease. The study reveals molecular mechanisms underlying the interaction between diabetes and chronic kidney disease, improving precision in diagnosing renal impairment.
NPJ DIGITAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Angelica Dessi, Alice Bosco, Flaminia Cesare Marincola, Roberta Pintus, Giulia Paci, Luigi Atzori, Vassilios Fanos, Cristina Piras
Summary: In this study, the urinary metabolomic profile of newborns of diabetic mothers was analyzed using NMR spectroscopy and GS-MS. Differences in metabolite levels were observed at birth, but not in subsequent sampling times. Early nutrition was considered as a potential contributing factor to these metabolic changes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Agriculture, Multidisciplinary
Wei Quan, Ye Jiao, Chaoyi Xue, Yong Li, Guoping Liu, Zhiyong He, Fang Qin, Maomao Zeng, Jie Chen
Summary: This study investigated the impact of exogenous free N-epsilon-(carboxymethyl) lysine (CML) from daily diet on diabetic-model Goto-Kakizaki rats. The results showed that feeding diabetic rats with free CML led to increased blood glucose levels and altered oxidative stress, as well as significant changes in various metabolites related to citric acid cycle and amino acid and carbohydrate metabolism, potentially contributing to the progression of diabetes and its complications.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Review
Ophthalmology
Xiao-Wen Hou, Ying Wang, Chen-Wei Pan
Summary: Metabolomics studies have identified potential biomarkers and metabolic pathways for diabetic retinopathy. Metabolites like L-glutamine and L-lactic acid may offer new diagnostic insights into DR. Dysregulation of amino acid and energy metabolism pathways are implicated in the development of this microvascular complication of diabetes.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2021)
Article
Endocrinology & Metabolism
Yuwei Tan, Xiaosong Liu, Yinping Yang, Baoying Li, Fei Yu, Wenqian Zhao, Chunli Fu, Xin Yu, Zhenxia Han, Mei Cheng
Summary: Diabetic sarcopenia (DS) is a disease characterized by muscle atrophy, slower nerve conduction, reduced muscle contraction capacity, and slower contraction rate. Serum metabolomics analysis identified potential biomarkers and revealed the underlying pathophysiological mechanism of DS. These findings provide new insights for the treatment of DS.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Rama J. Wahab, Vincent W. V. Jaddoe, Ellis Voerman, George J. G. Ruijter, Janine F. Felix, Linda Marchioro, Olaf Uhl, Engy Shokry, Berthold Koletzko, Romy Gaillard
Summary: Maternal prepregnancy BMI is associated with altered maternal early-pregnancy amino acids, nonesterified fatty acids, phospholipids, and carnitines concentrations. A metabolite profile identified in this study improved the prediction of birthweight in women with a higher prepregnancy BMI compared to glucose and lipid concentrations.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Biochemistry & Molecular Biology
Patricia Ancel, Jean Charles Martin, Elisa Doukbi, Marie Houssays, Pierre Gascon, Maud Righini, Frederic Matonti, Ljubica Svilar, Marie Valmori, Catherine Tardivel, Nicolas Venteclef, Jean Baptiste Julla, Jean Francois Gautier, Noemie Resseguier, Anne Dutour, Benedicte Gaborit
Summary: Diabetic retinopathy (DR) is a main cause of vision loss in the working-age population with diabetes. This study found metabolic and lipid changes in plasma samples from patients with DR, and identified deregulated pathways associated with the disease. Furthermore, specific signatures were found in different subgroups of DR. These findings provide a basis for potential plasma biomarkers and advancing personalized medicine for DR.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Rama J. Wahab, Vincent W. V. Jaddoe, Romy Gaillard
Summary: Women with obesity or who are overweight receive intensified antenatal care due to their increased risk of pregnancy complications. A prediction model based on maternal characteristics moderately predicts a healthy pregnancy outcome in these women, while early-pregnancy metabolites did not improve the model's performance.
Review
Endocrinology & Metabolism
Ye Sun, Ling Kong, Ai-Hua Zhang, Ying Han, Hui Sun, Guang-Li Yan, Xi-Jun Wang
Summary: Diabetic retinopathy, a serious complication of diabetes, is a leading cause of blindness worldwide. The irreversibility of the condition makes current treatment methods unsatisfactory. Early detection and intervention are important in reducing the damage caused by diabetic retinopathy. Metabolomics, a branch of systems biology, can identify characteristic metabolic changes associated with the progression of diabetic retinopathy and discover potential biomarkers for clinical diagnosis and treatment. This review summarizes the known metabolomics biomarkers of diabetic retinopathy and discusses the possibility of the arginine-creatine metabolic pathway as a therapeutic strategy.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Ricardo Wesley Alberca, Yasmim Alefe Leuzzi Ramos, Natalli Zanete Pereira, Danielle Rosa Beserra, Anna Claudia Calvielli Castelo Branco, Raquel Leao Orfali, Valeria Aoki, Alberto Jose da Silva Duarte, Maria Notomi Sato
Summary: The study investigated the long-term impact of COVID-19 on diabetic patients and found no long-term changes in inflammatory biomarkers. However, an increase in blood glucose and glycated hemoglobin was detected in non-diabetic patients.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Endocrinology & Metabolism
Jing Yang, Dongwei Liu, Zhangsuo Liu
Summary: This study aimed to explore the endothelial dysfunction mechanisms caused by serum exosomes from diabetic retinopathy and diabetic nephropathy patients. The results suggest that serum exosomes from these patients may cause endothelial dysfunction by upregulating the alpha subunit of fibrinogen and downregulating 1-methylhistidine. Bioinformatics analysis indicated that reduced cysteine and methionine metabolism played an important role in this process.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Endocrinology & Metabolism
Xiaodan Zhang, Zirui Luo, Jiahong Li, Yaxuan Lin, Yu Li, Wangen Li
Summary: This article reviews the progress in investigating the correlations between Sestrin2 protein, diabetes, and diabetic complications. Sestrin2 plays a crucial role in regulating cellular events such as oxidative stress, mitochondrial function, and endoplasmic reticulum stress. By exploring the potential roles of Sestrin2 in the pathogenesis of diabetes and diabetic complications, the authors aim to highlight a promising therapeutic direction.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Neurosciences
Prabhsimran Kaur, Sushil Kotru, Sandeep Singh, Anjana Munshi
Summary: Accelerating cases of diabetes worldwide have led to increased incidences of diabetic complications. miRNAs play a significant role in the pathogenesis of diabetes mellitus and contribute to various complications. This review summarizes the involvement of miRNAs in diabetic neuropathy and the diabetic foot, and discusses the potential applications of miRNAs as biomarkers and therapeutic targets.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Urology & Nephrology
Fanliang Zhang, Ruixue Guo, Wen Cui, Li Wang, Jing Xiao, Jin Shang, Zhanzheng Zhao
Summary: The study used untargeted metabolomic techniques to reveal serum metabolite profiles in patients with diabetic glomerulopathy (DG) compared to healthy controls, highlighting the significant role of tryptophan metabolism in the pathogenesis of DG. Differential metabolites were identified, with tryptophan derivatives showing accumulation in DG patients and depletion in healthy controls. Correlation analysis showed associations between specific metabolites and renal function indices in DG patients.
Review
Endocrinology & Metabolism
Fangqin Wu, Pengfei Liang
Summary: Metabolomics plays an important role in the detection, diagnosis, and treatment of diabetes, and metabolic markers characteristic of diabetes have been identified. However, the pathogenesis of diabetes is still not fully understood, and there is no cure available. Therefore, prevention and treatment are crucial.
DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
(2022)