Article
Multidisciplinary Sciences
Urko Del Castillo, Rosalind Norkett, Wen Lu, Anna Serpinskaya, Vladimir Gelfand
Summary: Ataxin-2 plays a crucial role in regulating neuronal cytoskeletal dynamics and organelle trafficking, as evidenced by fruit fly models, where its loss led to defects in nervous system development and survival.
Article
Cell Biology
Hyo-Jeong Yong, Jong-Ik Hwang, Jae-Young Seong
Summary: This study highlights the critical role of FAM19A1 in neuronal maturation and function by affecting dendritic spine development and neurite arborization, demonstrating its involvement in maintaining neural integrity and connectivity.
Article
Biochemistry & Molecular Biology
Jorge A. Sierra-Fonseca, Manuel Miranda, Siddhartha Das, Sukla Roychowdhury
Summary: The b gamma subunit of heterotrimeric G proteins interacts with both microtubules and actin filaments, playing a key role in modulating the neuronal cytoskeleton and participating in various aspects of neuronal differentiation. The interaction of Gb gamma with actin is independent of microtubules, and contributes to axon and growth cone formation during neuronal differentiation.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Chemistry, Medicinal
Xiu-Xiu Wang, Fei Xie, Cong-Cong Jia, Ning Yan, Yan-Li Zeng, Jing-De Wu, Zhao-Peng Liu
Summary: Histone deacetylase 6 (HDAC6) is a potential target for Alzheimer's disease (AD). In this study, a series of novel HDAC6 inhibitors were designed and synthesized, with phenothiazine-based hydroxamic acid W5 showing high potency and selectivity in inhibiting HDAC6. This compound demonstrated protective effects on AD-related proteins and neuronal neurite outgrowth, suggesting its potential as a lead compound for developing new AD treatments targeting multiple facets of the disease.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Chemistry, Analytical
Lurong Ding, Hao Ding, Ping Zhou, Lingling Xi, Bin Su
Summary: This work presents a surface-sensitive imaging methodology for evaluating cell-matrix adhesion differences at the single cell level and analyzing the impact of the chemical microenvironment on cell behaviors. The study reveals that different surface modifications lead to varying strengths of cell-matrix adhesion, and specific integrin subunits exhibit selective recognition to different surfaces.
ANALYTICAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
J. Michael Henderson, Nina Ljubojevic, Sevan Belian, Thibault Chaze, Daryl Castaneda, Aude Battistella, Quentin Giai Gianetto, Mariette Matondo, Stephanie Descroix, Patricia Bassereau, Chiara Zurzolo
Summary: Tunnelling nanotubes (TNTs) are specialized actin-based protrusions that bridge distant cells to facilitate direct intercellular communication and cargo transfer in both physiological and pathological contexts. Linear actin filament elongation induced by Eps8 and IRSp53 is shown to promote functional and stable TNT formation. A micropatterning approach shows that TNTs originate via actin polymerization rather than cell dislodgement and exceed the length of conventional filopodia. Inhibition of Arp2/3 activity promotes functional TNT formation due to enhanced actin filament polymerization and elongation, suggesting a shift from branched to linear actin. An interaction between Eps8 and the I-BAR domain protein IRSp53 promotes formation of functional TNTs with an increased lifetime. Arp2/3 inhibition leads to reduction of Eps8 interactions with proteins facilitating actin filament depolymerization and turnover. Inhibition of branched actin networks reveals the role of linear actin filament polymerization in the formation of functional tunnelling nanotubes.
Article
Pharmacology & Pharmacy
Artem I. Fokin, Roman N. Chuprov-Netochin, Alexander S. Malyshev, Stephane Romero, Marina N. Semenova, Leonid D. Konyushkin, Sergey V. Leonov, Victor V. Semenov, Alexis M. Gautreau
Summary: Several compounds structurally related to CK-666 were found to suppress Arp2/3 activation, and two of them demonstrated improved in vivo efficiency compared to CK-666.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biology
Ikuko Maejima, Taichi Hara, Satoshi Tsukamoto, Hiroyuki Koizumi, Takeshi Kawauchi, Tomoko Akuzawa, Rika Hirai, Hisae Kobayashi, Inoya Isobe, Kazuo Emoto, Hidetaka Kosako, Ken Sato
Summary: RAB35 is a multifunctional small GTPase that regulates endocytic recycling, cytoskeletal rearrangement, and cytokinesis. Our findings revealed that RAB35 is required for precise neuronal distribution in the developing hippocampus by regulating the expression of cell adhesion molecules, thereby influencing spatial memory. Mice with a brain-specific knockout of the Rab35 GTPase exhibit defects in spatial memory and hippocampal lamination, outlining a key role for Rab35 in hippocampal development and function.
COMMUNICATIONS BIOLOGY
(2023)
Review
Chemistry, Multidisciplinary
Sergey Klochkov, Margarita Neganova
Summary: Securinine is a unique indolizidine alkaloid with broad spectrum of actions like anti-inflammatory, antibacterial, neuroprotective, and antitumor. Its synthesis is challenging due to several reactive centers.
Article
Environmental Sciences
Zhiwen Yang, Wenyi Zou, Yongning Pan, Ken-Tye Yong, Li Li, Xiaomei Wang, Dongmeng Liu, Tingting Chen, Dahui Xue, Guimiao Lin
Summary: The study revealed that PEGylated CuInS2/ZnS QDs did not affect the survival rate of neuron-like PC12 cells within a certain concentration range, but significantly inhibited neurite outgrowth and differentiation in the presence of NGF. The QDs were found to downregulate the expression of low-affinity NGF receptor and negatively regulate the downstream MAPK cascade.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Neurosciences
Elly E. Liao, Mu Yang, Noah Nathan Kochen, Nagamani Vunnam, Anthony R. Braun, David M. Ferguson, Jonathan N. Sachs
Summary: In this study, the proteasomal activation by MK886 (MK) was investigated, and it was found that MK can activate the proteasome and reduce tau-induced neurite pathology. The structural permutations of MK also affect its activity.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Neurosciences
Alex Xiong Gao, Tracy Chen-Xi Xia, Lish Sheng-Ying Lin, Tina Ting-Xia Dong, Karl Wah-Keung Tsim
Summary: We aimed to investigate the neurotrophic activities of apigenin (4',5,7-trihydroxyflavone) through its interaction with brain-derived neurotrophic factor (BDNF) and the activation of tyrosine kinase receptor B (Trk B receptor). Our results showed that apigenin and BDNF synergistically enhanced the survival and neurite outgrowth of cultured neurons. Apigenin also potentiated the neurogenesis induced by BDNF and protected against amyloid-beta-induced cytotoxicity and mitochondrial dysfunction. These effects were mediated by the phosphorylation of Trk B receptor. In conclusion, apigenin can enhance the neurotrophic effects of BDNF and may have therapeutic potential in neurodegenerative diseases and depression.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Biochemistry & Molecular Biology
Fayi Nie, Qiaoxia Zhang, Jie Ma, Pengjie Wang, Ruiying Gu, Jing Han, Rui Zhang
Summary: This study demonstrates that EGR3 regulates neurite outgrowth via the Reelin signaling pathway, is positively correlated with schizophrenia, and may provide a new understanding of the molecular mechanisms of the disorder.
JOURNAL OF NEUROCHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Ning Yan, Xiao-Long Shi, Long-Qian Tang, De-Feng Wang, Xun Li, Chao Liu, Zhao-Peng Liu
Summary: A series of novel thieno[3,2-c]pyrazol-3-amine derivatives were designed and synthesized as potential GSK-3 beta inhibitors, among which 16b was identified as a potent inhibitor. At the cellular level, 16b showed no toxicity and effectively promoted neuronal differentiation and neurite outgrowth.
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
(2022)
Article
Chemistry, Medicinal
Xiaohui Chen, Xuefeng Jin, Fengtao Huang, Juntao Wang, Xuefeng Cao, Peng George Wang, Yan Feng, Faqin Jiang, Guangyu Yang
Summary: In this study, an efficient enzymatic synthetic system was developed to prepare various GM1 derivatives, and one derivative GM1 (d18:1/C16:1) was found to promote neurite outgrowth. Further analysis revealed that the promotion of nerve cell growth by GM1 (d18:1/C16:1) may involve the regulation of cholesterol biosynthesis and activation of the PI3K-mTOR pathway.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)