Article
Audiology & Speech-Language Pathology
Kenneth Morse, Kathy Vander Werff
Summary: The study aimed to evaluate the evidence of reduced inhibition and increased excitation in individuals with tinnitus at the subcortical auditory processing level. The results showed trends consistent with reduced peripheral to central brainstem auditory activity in the tinnitus group, but none of the group differences reached significance. The findings suggest that reduced subcortical inhibition may not be a primary underlying mechanism for tinnitus.
Article
Clinical Neurology
Eun Hye Kim, Seung-Ho Shin, Sung Wan Byun, Ho Yun Lee
Summary: This study aimed to confirm the characteristics of auditory function alterations in tinnitus patients with concomitant decreased sound tolerance (ST). The study found that tinnitus patients with decreased ST showed higher DPOAE amplitudes, shortened latency, and decreased threshold of ABR wave V. The study also revealed a possible association between decreased sound tolerance and lesions in or around the superior olivary complex or higher central auditory pathway.
FRONTIERS IN NEUROLOGY
(2023)
Article
Chemistry, Analytical
Ingrid G. Rodriguez-Leon, Luz Maria Alonso-Valerdi, Ricardo A. Salido-Ruiz, Israel Roman-Godinez, David I. Ibarra-Zarate, Sulema Torres-Ramos
Summary: This study aims to establish an objective methodology to measure changes in attentional processes in patients with tinnitus treated with auditory discrimination therapy (ADT). By analyzing EEG signals, the study found strong evidence of the feasibility of ADT for treating tinnitus, possibly through attentional redirection.
Article
Neurosciences
Jindi Zhao, Yuancheng Yang, Xingwei An, Shuang Liu, Hongyin Du, Dong Ming
Summary: This study analyzed the brain response to Chinese name stimuli and found that the passive mode using three Chinese characters as non-target stimuli can be a good alternative to the active mode. It also found that the brain response induced by the target stimulus has better interaction when three Chinese characters are used as the non-target stimulus.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Clinical Neurology
Irina Schierholz, Constanze Schoenermark, Esther Ruigendijk, Andrej Kral, Bruno Kopp, Andreas Buechner
Summary: The study found that post-lingually deafened CI users exhibit enhanced attention allocation to auditory oddball stimuli. However, there were similar attentional modulations in other ERP amplitudes between CI users and NH controls.
CLINICAL NEUROPHYSIOLOGY
(2021)
Article
Psychiatry
Prune Mazer, Ines Macedo, Tiago O. Paiva, Fernando Ferreira-Santos, Rita Pasion, Fernando Barbosa, Pedro Almeida, Celeste Silveira, Cassilda Cunha-Reis, Joao Marques-Teixeira
Summary: The study used a roving paradigm to assess the modulation and habituation of N1 and P2 to simple and complex sounds in first-episode schizophrenia patients and healthy participants. The results showed that patients exhibited abnormal habituation to bird songs, while showing preserved auditory processing of human voices.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Multidisciplinary Sciences
Peter T. Johannesen, Enrique A. Lopez-Poveda
Summary: As people age, central gain compensation occurs, which is not specific to individuals with tinnitus.
Article
Neurosciences
Luz M. Alonso-Valerdi, David I. Ibarra-Zarate, Alma S. Torres-Torres, Daniela M. Zolezzi, Norberto E. Naal-Ruiz, Janet Arguello-Garcia
Summary: This study proposes a methodology based on Auditory Event-Related Potential (AERP) features to evaluate the effectiveness of four acoustic therapies for tinnitus treatment. After an 8-week treatment, significant neurophysiological changes were found in somatosensory and occipital regions for Tinnitus Retraining Therapy (TRT) and Auditory Discrimination Therapy (ADT), respectively. TRT increased tinnitus perception while ADT diminished it.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Psychology, Multidisciplinary
Yubin Zhang, Chotiga Pattamadilok, Dustin Kai-Yan Lau, Mehdi Bakhtiar, Long-Ying Yim, Ka-Yui Leung, Caicai Zhang
Summary: The study investigates the impact of alphabetic literacy acquisition on phonological awareness, with proficient users of a Romanization system showing better performance in phoneme judgment tasks and exhibiting more negative ERP components in the early P1-N1-P2 time-windows.
FRONTIERS IN PSYCHOLOGY
(2021)
Article
Acoustics
Jason Mulsow, James J. Finneran, Dorian S. Houser, Robert F. Burkard, Madelyn G. Strahan, Ryan Jones
Summary: Studies on dolphin auditory brainstem response (ABR) have shown that the response to sound offset includes contributions from at least two distinct responses, with one possibly arising from activation of neural units shifted basally relative to stimulus frequency, and the other representing a true offset response from afferent centers further up the auditory pathway.
JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA
(2021)
Article
Geriatrics & Gerontology
Farooq Kamal, Cassandra Morrison, Kenneth Campbell, Vanessa Taler
Summary: Research is focusing on developing a simple and low-cost method to detect early signs of Alzheimer's disease pathology. This study used event-related potentials to compare auditory processing between healthy older adults and individuals with mild cognitive impairment, finding differences in late positivity between the groups under slow auditory stimulus presentation.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Review
Neurosciences
Sarah Elizabeth Rotschafer
Summary: Autism spectrum disorder (ASD) is increasingly common, with altered sensory processing, especially auditory sensitivities, being typical. Individuals with ASD often show heightened sensitivity to environmental sounds and have difficulty tolerating loud sounds, which may contribute to impairments in language comprehension and sound discrimination. Event-related potential tests have revealed altered cortical activity in individuals with ASD, which likely plays a role in the observed processing impairments.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Kenji Tanaka, Shuma Ohara, Tadaaki Matsuzaka, Aira Matsugaki, Takuya Ishimoto, Ryosuke Ozasa, Yukiko Kuroda, Koichi Matsuo, Takayoshi Nakano
Summary: The auditory brainstem response (ABR) is commonly used to assess auditory function, but determining the ABR threshold has been a challenge. Existing methods lack accuracy, efficiency, and convenience. We proposed an improved algorithm based on mutual covariance to objectively determine the ABR threshold. This method effectively reduced the burden on experimental animals and provided more efficient and accurate results.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Gavin M. Bidelman, Sara Momtaz
Summary: In this study, scalp-recorded frequency-following responses (FFRs) were used to assess the relationship between brain activity and speech-in-noise (SIN) perception in normal-hearing adults. The results indicated that subcortical sources play a dominant role in driving the FFR strength and its connection to SIN listening skills. This suggests that subcortical processing may be key in understanding complex listening abilities in noisy environments.
NEUROSCIENCE LETTERS
(2021)
Article
Behavioral Sciences
Clement Donde, Joshua T. Kantrowitz, Alice Medalia, Alice M. Saperstein, Andrea Balla, Pejman Sehatpour, Antigona Martinez, Monica N. O'Connell, Daniel C. Javitt
Summary: Schizophrenia is a major mental disorder affecting 1% of the global population. Cognitive deficits, particularly in early auditory processes, are a significant feature of the disorder and contribute to long-term disability. This review examines the behavioral and neurophysiological aspects of early auditory dysfunction in schizophrenia, as well as its relationship with higher order cognitive functions and social cognition. The review also discusses pathological processes involving glutamate and NMDAR dysfunction, and highlights the potential utility of early auditory measures as treatment targets and translational biomarkers for investigating the etiology of schizophrenia.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2023)
Article
Neurosciences
Jessica Winne, Barbara C. Boerner, Thawann Malfatti, Elis Brisa, Jhulimar Doerl, Ingrid Nogueira, Katarina E. Leao, Richardson N. Leao
EXPERIMENTAL NEUROLOGY
(2020)
Article
Biochemistry & Molecular Biology
Menilla Maria Alves de Melo, Veronica da Silva Oliveira, Moacir Fernandes de Queiroz Neto, Weslley de Souza Paiva, Manoela Torres-Rego, Sergio Ruschi Bergamachi Silva, Daniel de Lima Pontes, Hugo Alexandre Oliveira Rocha, Miguel Angelo Fonseca de Souza, Arnobio Antonio da Silva-Junior, Matheus de Freitas Fernandes-Pedrosa
Summary: TanP, an anionic peptide with chelating and immunomodulatory properties, exhibits stable complex formation and recognition abilities towards Fe2+ and Zn2+ ions. It also demonstrates antioxidant, hemostatic, and healing activities, making it a potential prototype for the development of new therapeutic and biotechnological agents.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Biology
Thawann Malfatti, Barbara Ciralli, Markus M. Hilscher, Richardson N. Leao, Katarina E. Leao
Summary: Lowering the activity of the dorsal cochlear nucleus reduces tinnitus in mice, but lowering activity during noise exposure does not prevent noise-induced tinnitus. CaMKII alpha-positive cells in the dorsal cochlear nucleus play a significant role in maintaining the perception of tinnitus in mice.
Article
Neurosciences
Isis M. Ornelas, Felipe A. Cini, Isabel Wiessner, Encarni Marcos, Draulio B. Araujo, Livia Goto-Silva, Juliana Nascimento, Sergio R. B. Silva, Marcelo N. Costa, Marcelo Falchi, Rodolfo Olivieri, Fernanda Palhano-Fontes, Eduardo Sequerra, Daniel Martins-de-Souza, Amanda Feilding, Cesar Renno-Costa, Luis Fernando Tofoli, Stevens K. Rehen, Sidarta Ribeiro
Summary: The therapeutic use of LSD has increased in recent years due to its ability to enhance neural plasticity and improve cognition.
EXPERIMENTAL NEUROLOGY
(2022)
Article
Biochemistry & Molecular Biology
Lucas Pinheiro Coutinho, Sergio Ruschi Bergamachi Silva, Pedro de Lima-Neto, Norberto de Kassio Vieira Monteiro
Summary: This article introduces the mechanism of action of psychoactive natural products and the biosynthetic pathway of DMT, and proposes a research method based on computational modeling to reveal the molecular details of tryptamine double methylation.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Neurosciences
Thawann Malfatti, Barbara Ciralli, Markus M. Hilscher, Steven J. Edwards, Klas Kullander, Richardson N. Leao, Katarina E. Leao
Summary: This study aimed to target specific neuronal populations in the dorsal cochlear nucleus (DCN) using genetic tools, but found limitations in the ability to target excitatory neurons with the CaMKII alpha promoter. Stimulation and activation of certain proteins could increase firing rates of excitatory neurons, potentially aiding in tinnitus research.