Explaining in-vitro to in-vivo efficacy correlations in oncology pre-clinical development via a semi-mechanistic mathematical model

Comparison of classical tumour growth models for patient derived and cell-line derived xenografts using the nonlinear mixed-effects framework

(2022) Dimitrios Voulgarelis et al.   Journal of Biological Dynamics

Growth‐rate model predicts in vivo tumor response from in vitro data

(2022) Rocky Diegmiller et al.   CPT-Pharmacometrics & Systems Pharmacology

Anti-tumor efficacy of a potent and selective non-covalent KRASG12D inhibitor

(2022) Jill Hallin et al.   NATURE MEDICINE

Exploring a model-based analysis of patient derived xenograft studies in oncology drug development

(2021) Jake Dickinson et al.   PeerJ

How translational modeling in oncology needs to get the mechanism just right

(2021) James W. T. Yates et al.   CTS-Clinical and Translational Science

Small Models for Big Data

(2020) Hitesh B. Mistry et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Population modeling of tumor growth curves and the reduced Gompertz model improve prediction of the age of experimental tumors

(2020) Cristina Vaghi et al.   PLoS Computational Biology

Does In Vitro Potency Predict Clinically Efficacious Concentrations?

(2020) Rasmus Jansson‐Löfmark et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Optimizing the Therapeutic Window of Targeted Drugs in Oncology: Potency‐guided First‐in‐Human Studies

(2020) Matthew J Goldstein et al.   CTS-Clinical and Translational Science

Resistance models to EGFR inhibition and chemotherapy in non-small cell lung cancer via analysis of tumour size dynamics

(2019) Hitesh B. Mistry et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Requirements to Establishing Confidence in Physiologically Based Pharmacokinetic (PBPK) Models and Overcoming Some of the Challenges to Meeting Them

(2019) Sheila Annie Peters et al.   CLINICAL PHARMACOKINETICS

A simple model of a growing tumour

(2019) David Orrell et al.   PeerJ

Optimization of human dose prediction by using quantitative and translational pharmacology in drug discovery

(2015) Tjerk Bueters et al.   Future Medicinal Chemistry

The Project Data Sphere Initiative: Accelerating Cancer Research by Sharing Data

(2015) A. K. Green et al.   ONCOLOGIST

Classical Mathematical Models for Description and Prediction of Experimental Tumor Growth

(2014) Sébastien Benzekry et al.   PLoS Computational Biology

Modelling of tumour growth and cytotoxic effect of docetaxel in xenografts

(2013) Neil D. Evans et al.   COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE

Model-based drug discovery: implementation and impact

(2013) Sandra A.G. Visser et al.   DRUG DISCOVERY TODAY

Dynamic tumor modeling of the dose–response relationship for everolimus in metastatic renal cell carcinoma using data from the phase 3 RECORD-1 trial

(2012) Andrew Stein et al.   BMC CANCER

Bridging the Gap between Preclinical and Clinical Studies Using Pharmacokinetic-Pharmacodynamic Modeling: An Analysis of GDC-0973, a MEK Inhibitor

(2012) H. Wong et al.   CLINICAL CANCER RESEARCH

In vitro–in vivo correlation: Perspectives on model development

(2011) Ying Lu et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Elucidation of Relationship Between Tumor Size and Survival in Non-Small-Cell Lung Cancer Patients Can Aid Early Decision Making in Clinical Drug Development

(2009) Y Wang et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS