期刊
MOLECULAR AND CELLULAR ENDOCRINOLOGY
卷 438, 期 C, 页码 3-17出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.mce.2016.09.031
关键词
Tuberal hypothalamus; Neurogenesis; Gliogenesis; Hypothalamic development; Endocrine disrupting chemicals; Neuroendocrine disorders
资金
- University of Calgary
- Canadian Institutes of Health Research [MOP-275053]
- Natural Sciences and Engineering Research Council of Canada [DG386445]
The hypothalamus is a critical regulator of body homeostasis, influencing the autonomic nervous system and releasing trophic hormones to modulate the endocrine system. The developmental mechanisms that govern formation of the mature hypothalamus are becoming increasingly understood as research in this area grows, leading us to gain appreciation for how these developmental programs are susceptible to disruption by maternal exposure to endocrine disrupting chemicals or other environmental factors in utero. These vulnerabilities, combined with the prominent roles of the various hypothalamic nuclei in regulating appetite, reproductive behaviour, mood, and other physiologies, create a window whereby early developmental disruption can have potent long-term effects. Here we broadly outline our current understanding of hypothalamic development, with a particular focus on the tuberal hypothalamus, including what is know about nuclear coalescing and maturation. We finish by discussing how exposure to environmental or maternally-derived factors can perhaps disrupt these hypothalamic developmental programs, and potentially lead to neuroendocrine disease states. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
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