期刊
MOLECULAR AND CELLULAR ENDOCRINOLOGY
卷 437, 期 C, 页码 154-162出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.mce.2016.08.027
关键词
Obesity; Testicular steroidogenesis; Sex hormones; TNF alpha
资金
- European Union [634880]
- Swedish Research Council
- Children's Cancer Fund
- Frimurare Barnhuset Foundation
- Kronprinsessan Lovisas Foundation
- Sallskapet Barnavard
- Stiftelsen Samariten
- Stiftelsen Olle Engkvist Byggmastare
- Stiftelsen Gunvor och Josef Aners
- Stiftelsen Anna-Brita och Bo Castegrens Minne
- Stiftelsen Sigurd och Elsa Goljes Minne
- Stiftelsen Tornspiran
- ESPE Research Fellowship (European Society for Pediatric Endocrinology)
- IFB Adiposity Diseases [01E01501]
- [SFB1052]
- [B04]
Obesity is a global health problem and impacts negatively on levels of testosterone and quality of sperm production. At present little is known about mechanisms that attenuate testicular function in obese males. Our study characterized testicular steroidogenesis and explored levels of relevant paracrine and hormonal factors in rats with short- and long-term obesity. We have found that obesity state increased serum levels of estradiol and leptin in both groups of obese rats and inhibited the expression of StAR and Cyp11a1 associated with low levels of intratesticular testosterone in rats with long-term obesity. Further, long-term obesity reduced the number of Leydig cells, increased the testicular levels of the proinflammatory adipocytokine TNF alpha and the number of testicular macrophages. All together, our data indicate that long-term obesity may cause chronic inflammation in the testis and negatively impacts on Leydig cell steroidogenesis. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
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