Article
Ophthalmology
Ho Sik Hwang, Eric Mikula, Yilu Xie, Donald J. Brown, James V. Jester
Summary: A novel mouse transillumination meibography device was developed and successfully used to detect age-related changes in meibomian glands of young and old mice. Older mice exhibited meibomian gland dropout and irregular shapes.
Article
Medicine, General & Internal
Reiko Arita, Shima Fukuoka, Motoko Kawashima
Summary: Treatment selection for meibomian gland dysfunction (MGD) should be based on a comprehensive stage classification that includes ocular symptoms, lid margin abnormalities, meibum grade, and ocular surface staining. Different treatment modalities have varying efficacy based on the meiboscore determined by noncontact meibography, with intense pulsed light therapy showing improvement even in cases with high meiboscore. Prospective studies are needed to further validate these findings.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Zuhui Zhang, Xiaolei Lin, Xinxin Yu, Yana Fu, Xiaoyu Chen, Weihua Yang, Qi Dai
Summary: The study aimed to establish an AI system based on deep learning and transfer learning for meibomian gland (MG) segmentation and evaluate the efficacy of MG density in the diagnosis of MG dysfunction (MGD). The AI system achieved high accuracy and repeatability in MG segmentation after training, and there was a significant correlation between MG density and various clinical indices. MG density is an effective index for MGD, especially when supported by an AI system.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Xiangjun Chen, Reza A. Badian, Havard Hynne, Behzod Tashbayev, Lene Hystad Hove, Janicke Liaaen Jensen, Tor Paaske Utheim
Summary: In this study, meibography of 65-year-old residents in Oslo, Norway was analyzed, and it was found that moderate meibomian gland atrophy was common and not gender-specific. Meibography alone cannot discriminate between meibomian gland dysfunction (MGD) and non-MGD, thus both morphological and functional tests are necessary for screening MGD.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Ophthalmology
Hua Chen, Hui Gao, Hua-Tao Xie, Shu-Ting Liu, Yu-Kan Huang, Ming-Chang Zhang
Summary: The study revealed that treatment with Staphylococcus aureus crude extracts (SACEs) led to overexpression of keratin 1 (Krt1) in the ducts and acini of meibomian gland (MG) explants, along with decreased viability and increased cell death. SACEs treatment also dose-dependently increased levels of pro-inflammatory cytokines in MG explants and activated the NF-kappa B and AIM2/ASC signaling pathways.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2021)
Article
Medicine, General & Internal
Reiko Arita, Shima Fukuoka
Summary: This study evaluated the efficacy and safety of intense pulsed light (IPL) combined with meibomian gland expression (MGX) for the treatment of refractory multiple and recurrent chalazia. The combination therapy significantly improved all parameters except meiboscore and the Schirmer value, while MGX alone only significantly improved meibum grade. No adverse events occurred in either group. IPL-MGX treatment was effective and safe for multiple and recurrent chalazia without surgery or curettage.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Ophthalmology
Minji Ha, Jin Soo Kim, Seo-Yeon Hong, Dong-Jin Chang, Woong-Joo Whang, Kyung-Sun Na, Eun Chul Kim, Hyun Seung Kim, Ho Sik Hwang
Summary: The study revealed associations between lid margin abnormalities and meibomian gland loss, particularly irregular lid margins in the upper eyelids were correlated with higher degrees of meibomian gland loss. In the lower eyelids, irregular lid margins and total grading score of lid margin abnormalities were associated with higher meibomian gland dropout.
Article
Cell Biology
Binge Huang, Fangrong Fei, Han Wen, Ye Zhu, Zhenzhen Wang, Shuwen Zhang, Liang Hu, Wei Chen, Qinxiang Zheng
Summary: This study used a deep-learning based artificial intelligence system to evaluate the effects of age and gender on meibomian gland parameters in aged people, as well as the associations among these parameters. The results showed that meibomian gland abnormalities increased with age, and were more severe in males and individuals who smoked or drank alcohol.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Igor Petricek, Martina Tomic, Tomislav Bulum, Dina Lesin Gacina, Sania Vidas Pauk
Summary: This cross-sectional study examined the relationship between meibomian gland excreta quantity and quality, dry eye disease symptoms, and objective signs of dry eye. The study found that subjects with dry eye symptoms had lower meibomian gland quantity scores compared to healthy controls. Meibum quality and quantity scores were associated with gender, dry eye symptoms, and objective signs of dry eye. Adjusted logistic regression analysis showed that dry eye was independently associated with self-reported skin type, lid parallel conjunctival folds, fluorescein corneal staining, tear break-up time, and meibum quantity score. The study established a correlation between dry eye symptoms caused by meibomian gland dysfunction and dry skin, which can help general health practitioners consider dry eye as a potential cause of chronic eye complaints in patients with dry skin.
Review
Ophthalmology
Kasandra Swiderska, Michael L. Read, Caroline A. Blackie, Carole Maldonado-Codina, Philip B. Morgan
Summary: This paper aims to review recent research in Meibomian gland imaging and provide updates on the most relevant technologies and approaches used in the field.
Article
Medicine, General & Internal
Qian Zheng, Yuanyuan Xue, Xiaowei Zhong, Guangwei Li, Weiyun Shi, Ting Wang
Summary: Meibomian gland dysfunction (MGD) patients with solid meibum showed more pronounced abnormalities in meibomian gland morphology, higher density of inflammatory cells, and worse tear quality, as observed through microscopy.
FRONTIERS IN MEDICINE
(2022)
Article
Ophthalmology
Taras Gout, Emma Grace Walshaw, Timothy Zoltie, Paul Bartlett, Tom Archer, Asmaa Altaie, Jiten Parmar, Nabil El-Hindy, Bernie Chang, George Kalantzis
Summary: This study evaluated patient reported outcomes of high definition ocular prostheses using validated questionnaires. Principal Component Analysis revealed two components with good reliability, validity, and responsiveness. An 80% questionnaire response rate indicated positive patient experiences with the new artificial eyes.
Article
Health Care Sciences & Services
Songjiao Zhao, Yankun Shen, Shinan Wu, Yi Shao, Ruize Shi, Yan Yan, Hui Zhao
Summary: The role of macrophage polarization regulated by TIPE2 in meibomian gland dysfunction (MGD) was investigated. The secretory function of the meibomian gland (MG) was examined in MGD mice and normal mice. The expression levels of markers of M1 and M2 macrophages were detected in MGD, normal mice, and MGD patients to determine their role in MGD inflammation. The expression levels of TIPE2 in MGD mice and MGD patients were also examined, and the correlations among TIPE2, M1 and M2 macrophages were analyzed.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Ingrid Zahn, Fabian Garreis, Martin Schicht, Vera Roetzer, Jens Waschke, Yuqiuhe Liu, Valerian L. Altersberger, Friedrich Paulsen, Jana Dietrich
Summary: A new 3D organotypic slice culture model of mouse meibomian glands (MGs) was established, which allows for the study of meibomian gland dysfunction (MGD) and dry eye disease (DED). The effects of melanocortins on exocrine secretion were investigated, potentially leading to new insights in the development of treatments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
Hyunmin Ahn, Bo Yi Kim, Jinyoung Kim, Yong Woo Ji, Ikhyun Jun, Tae-im Kim, Hyung Keun Lee, Kyoung Yul Seo
Summary: Maintaining eyelid hygiene is significantly effective in treating meibomian gland dysfunction, with the efficacy lasting up to 4 months after stopping the treatment.
JOURNAL OF CLINICAL MEDICINE
(2022)