Article
Cell Biology
Sora Kwon, Kiwon Ban, Young-Kwon Hong, Jung-Suk Sung, Inho Choi
Summary: The study demonstrates that rapamycin effectively inhibits the proliferation of hepatocellular carcinoma (HCC) cells and that Prospero-related homeobox 1 (PROX1) plays a key role in the anti-proliferative effect of rapamycin. The increased expression of PROX1 by MTOR inhibition can be used as a useful marker for predicting whether HCC cells can be affected by rapamycin.
Review
Gastroenterology & Hepatology
Lorenza Rimassa, Richard S. Finn, Bruno Sangro
Summary: Single-agent immune checkpoint inhibitors (ICIs) have limited efficacy in advanced hepatocellular carcinoma (HCC) patients, and approximately 30% of patients show intrinsic resistance to ICIs. Therefore, researchers are exploring combination therapies, such as anti-angiogenic agents and other ICIs. Some trials have shown promising results and potential for clinical application. However, there are still many unanswered questions that require further research.
JOURNAL OF HEPATOLOGY
(2023)
Review
Medicine, Research & Experimental
Mingzhen Zhou, Baorui Liu, Jie Shen
Summary: Hepatocellular carcinoma (HCC) is a common malignancy with late-appearing symptoms, making diagnosis and treatment challenging. Immunotherapy, including immune checkpoint inhibitors, liver cancer vaccines, and cellular therapies, has emerged as a new hope for HCC treatment by regulating the immune system to target liver cancer cells.
CLINICAL AND EXPERIMENTAL MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Hyun Young Woo, So Young Yoo, Jeong Heo
Summary: This article provides an overview of the recurrent issues in HCC and the potential of retinoid acid (RA) and its analogues in cancer treatment. It focuses on the clinical characteristics, safety profile and future prospects of the synthetic oral retinoid peretinoin as a secondary chemopreventive agent for HCC.
Review
Biochemistry & Molecular Biology
Laura Gramantieri, Francesca Fornari, Catia Giovannini, Davide Trere
Summary: miRNAs in HCC play a bidirectional role in both immune-related pathways and oncogenic pathways. Understanding their function can help identify patient subgroups and design personalized treatment strategies.
Review
Oncology
Maria Tampaki, George V. Papatheodoridis, Evangelos Cholongitas
Summary: Patients with decompensated hepatocellular carcinoma (HCC) have limited therapeutic options and are often excluded from clinical trials. Liver transplantation is the best treatment option, but strict criteria and donor shortages limit its availability. Locoregional treatments may provide a survival benefit if well tolerated. Systemic treatments, particularly immunotherapy, may be the safest choice based on real-life data. Close monitoring is necessary due to the high risk of liver disease deterioration.
Article
Biochemistry & Molecular Biology
Xiaoling Zhang, Hao Liu, Haidong Wang, Rongjie Zhao, Qian Lu, Yunlong Liu, Yicheng Han, Hongming Pan, Weidong Han
Summary: This study found that b3galt5 is highly expressed in hepatocellular carcinoma (HCC) and associated with poor prognosis. It promotes the proliferation and survival of HCC cells and activates the mTOR/p70s6k pathway to enhance glycolysis through O-linked glycosylation modification. Inhibition of p70s6k reduces glycolysis in b3galt5-overexpressing cells. This study uncovers a novel mechanism and potential therapy target for HCC.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Review
Cell Biology
May G. Akl, Scott B. Widenmaier
Summary: Hepatocellular carcinoma (HCC) is a major public health concern promoted by obesity-related liver complications. The transition from steatosis to steatohepatitis and from steatohepatitis to HCC involves complex interactions between metabolic and immune pathways. Understanding these immunometabolic changes associated with HCC in obesity may contribute to the development of targeted therapies.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Panupun Limpachayaporn, Sopon Nuchpun, Jitnapa Sirirak, Purin Charoensuksai, Pawaris Wongprayoon, Natthaya Chuaypen, Pisit Tangkijvanich, Apichart Suksamrarn
Summary: In this study, Thirty-one new compounds were synthesized and evaluated for their inhibitory activity against hepatocellular carcinoma cell line HepG2. Among them, derivative 5r exhibited the most potent anti-HepG2 activity and had a 5.2-times higher selectivity index (SI) compared to the parental molecule sorafenib.
BIOORGANIC & MEDICINAL CHEMISTRY
(2022)
Review
Immunology
Zhiyi Li, Ying Zhang, Baipan Zhang, Rui Guo, Minhua He, Zi-Ling Liu, Lei Yang, Hong Wang
Summary: Hepatocellular carcinoma is a significant global health concern with limited treatment options. Immunotherapy has shown promising advancements in the treatment of this disease, but research focus and trends are evolving.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Yuting Zhang, Huiting Huang, Libo Jin, Sue Lin
Summary: This review comprehensively summarizes the chemopreventive, anticancer, and chemosensitizing effects of isothiocyanates (ITCs) on hepatocellular carcinoma (HCC), as well as explaining the underlying molecular mechanisms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cell Biology
Saleh A. Alqahtani, Massimo Colombo
Summary: Chronic infections with hepatitis B or C virus are common risk factors for hepatocellular carcinoma. Effective antiviral therapies can reduce the risk of developing HCC, but do not eliminate it completely. More strategies are needed to further improve outcomes in preventing HCC in patients with chronic viral hepatitis.
Review
Oncology
Aroosha Raja, Farhan Haq
Summary: This review extensively summarizes current information on molecular classification of HCC, providing insight for understanding the development mechanisms and treatment options for liver cancer patients globally.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2022)
Review
Pharmacology & Pharmacy
Graziana Digiacomo, Roberta Pia Serra, Elena Turrini, Alessandra Tiri, Andrea Cavazzoni, Roberta Alfieri, Patrizia Bertolini
Summary: Hepatoblastoma and pediatric hepatocellular carcinoma are rare primary malignant liver cancers in children and young adults. Hepatoblastoma is the most common type, accounting for about 70% of cases, while pediatric hepatocellular carcinoma is uncommon and has a poor prognosis. Surgery is the best option for cure, but chemotherapy can be used as an additional treatment. Studies are being conducted to identify genetic profiles and potential targets for treatment.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Oncology
Huihui Wang, Shubing Zhang, Tao Li, Lianzi Wang, Wei Lv, Shanshan Wang, Dongyue Ma, Yan Zang, Xinyue Zhu, Yuanhong Xu, Lan Zheng, Jilong Shen, Wei Wei
Summary: This study found that miR-146a is overexpressed in HCC tissues and liver cancer cells, while FLAP protein and mRNA are suppressed. The experimental results showed that miR-146a can target FLAP mRNA, and silencing miR-146a or restoring FLAP can reduce the proliferation, cell cycle progression, migration, and invasion of HepG2 cells, indicating that miR-146a has a stimulatory role in HepG2 cells.
CANCER CELL INTERNATIONAL
(2022)
Article
Pharmacology & Pharmacy
Mohammad Imran, Vemana Gowd, Puspita Saha, Summya Rashid, Anis Ahmad Chaudhary, Marwa Yousry A. Mohamed, Abdullah S. Alawam, Rehan Khan
Summary: Nanotechnology is being used as a model for developing better treatments for various diseases, but it still faces challenges such as inadequate circulation, insufficient accumulation at the target region, and undesired toxicity. Scientists are producing cell-membrane camouflaged nanoparticles as a biomimetic technique to overcome these challenges and improve therapeutic efficacy. These biomimetic nanoparticles have potential applications in diagnosing and treating diseases, including drug administration, immunisation, immunological regulation, and detoxification.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Plant Sciences
Summya Rashid, Maryam Sameti, Mohammed H. Alqarni, Fatma M. Abdel Bar
Summary: This study provides scientific evidence for the therapeutic effects of P. harmala and its major alkaloids in the prevention and management of urolithiasis. The results demonstrate the anti-oxidative, anti-inflammatory, and kidney-protective properties of P. harmala and its constituents. It suggests that P. harmala could be a potential alternative or adjunct therapy for urolithiasis.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Medicine, General & Internal
Sri Rahavi Boovarahan, Suresh Babu Kale, Priyanka N. N. Prem, Sriram Ravindran, Akshayakeerthi Arthanarisami, Jeyashri Rengaraju, Nemat Ali, Senthilkumar Ramalingam, Mohamed Mohany, Abdullah F. AlAsmari, Salim S. S. Al-Rejaie, Mohammad Waseem, Gino A. A. Kurian
Summary: This study aims to investigate the association between DNA hypermethylation, mitochondrial dysfunction, and cognitive decline in post-surgical CABG patients. The results showed that MCI patients after CABG surgery exhibited increased expression of DNA methylation genes and decreased complex I activity, suggesting a correlation between cognitive decline and elevated DNMT1 expression and declined complex I activity.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Nutrition & Dietetics
Tarun Verma, Ankur Aggarwal, Priya Dey, Anil Kumar Chauhan, Summya Rashid, Kow-Tong Chen, Rohit Sharma
Summary: Garlic, an edible tuber from the Liliaceae family, has been used as a spice and remedy for various ailments since ancient times. It contains sulfur compounds such as allicin, ajoene, vinyl-dithiin, and other volatile organosulfur compounds, which have been found to possess antioxidant, antiviral, antimicrobial, antifungal, antihypertensive, anti-anemic, anti-hyperlipidemic, anticarcinogenic, antiaggregant, and immunomodulatory properties.
FRONTIERS IN NUTRITION
(2023)
Review
Biology
Faheem Anwar, Fatima Haider, Sarmir Khan, Ibrar Ahmad, Naveed Ahmed, Muhammad Imran, Summya Rashid, Zhi-Guang Ren, Saadullah Khattak, Xin-Ying Ji
Summary: Monkeypox virus is a zoonotic double-stranded DNA virus that causes disease in humans and mammals. It is associated with the smallpox virus and has been reported in various regions of Africa and the Northern and western hemispheres. This review focuses on the taxonomic classification, clinical presentations, and pathogenicity of the monkeypox virus in humans, as well as different diagnostic methods used for virus detection.
Article
Biochemistry & Molecular Biology
Arif Hassan Dar, Anas Ahmad, Ajay Kumar, Vijayendran Gowri, Chandrashekhar Jori, Shaifali Sartaliya, K. M. Neethu, Nemat Ali, Mahendra Bishnoi, Rehan Khan, Govindasamy Jayamurugan
Summary: This study focuses on the development of luminescent dyes based on TCBDs and their transformation into water-soluble nanoaggregates. These nanoaggregates exhibit high emissivity and have potential applications in bioimaging and photodynamic therapy, specifically targeting cancer cells and increasing cell death activity.
Article
Environmental Sciences
Talla Sasi Teja, Sandip Patil, Prince Chawla, Aarti Bains, Gulden Goksen, Nemat Ali, Abdullah F. AlAsmari, Sixi Liu, Feiqiu Wen
Summary: In this study, magnesium nanoparticles (Mg NPs) were synthesized using an aqueous extract of Berberis aristate rhizome and evaluated for their antimicrobial and anti-inflammatory activity. The results showed that Mg NPs exhibited potential inhibition against S. aureus and E. coli, indicating their potential in treating microbial infections.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL HEALTH RESEARCH
(2023)
Article
Chemistry, Medicinal
Nallupillai Paramakrishnan, Khian Giap Lim, Yamunna Paramaswaran, Nemat Ali, Mohammad Waseem, Gamal A. Shazly, Yousef A. Bin Jardan, Arunachalam Muthuraman
Summary: This study investigates the impact of AST on cerebrovascular disease-associated AD through the inhibition of MMP-13. The results show that AST can ameliorate behavioral and biochemical changes, making it a potential therapeutic approach for the management of AD.
Review
Biochemistry & Molecular Biology
Mateusz Kciuk, Manzar Alam, Nemat Ali, Summya Rashid, Pola Glowacka, Rajamanikandan Sundaraj, Ismail Celik, Esam Bashir Yahya, Amit Dubey, Enfale Zerroug, Renata Kontek
Summary: Cellular signaling pathways play a significant role in maintaining the balance between cell proliferation and apoptosis, making them rational targets for cancer prevention and treatment. Epigallocatechin-3-gallate (EGCG), the major phenolic compound in green tea, has been shown to regulate important cellular signaling pathways involved in the pathophysiology of cancer. EGCG has demonstrated anti-proliferative, anti-inflammatory, and apoptosis-inducing effects, as well as the ability to induce epigenetic changes. Preclinical and clinical studies suggest that EGCG may have therapeutic potential for various disorders, including cancer.
Article
Pharmacology & Pharmacy
Muhammad Usman Akbar, Saadullah Khattak, Malik Ihsanullah Khan, Umair Ali Khan Saddozai, Nemat Ali, Abdullah F. Alasmari, Muhammad Zaheer, Muhammad Badar
Summary: This study developed multifunctional bimetallic (FeCo) bi-MIL-88B-FC MOFs modified with folic acid-conjugated chitosan (FC) as drug delivery systems for targeted delivery of 5-Fluorouracil (5-FU). The results showed slower release of 5-FU due to a gated effect phenomenon endowed by FC surface coating. pH-responsive drug release was observed, with higher release in cancer cells mimicking pH compared to physiological pH. In vitro experiments demonstrated the superior cytotoxicity and cellular internalization of 5-FU@bi-MIL-88B-FC in folate receptor positive cancer cells. Moreover, the bi-MIL-88B exhibited peroxidase-like activity for chemodynamic therapy.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Tipare Bhagyashree Devidas, Sandip Patil, Minaxi Sharma, Nemat Ali, Mohammad Khalid Parvez, Mohammed S. Al-Dosari, Sixi Liu, Baskaran Stephen Inbaraj, Aarti Bains, Feiqiu Wen
Summary: Milletia pinnata oil and Nardostachys jatamansi were extracted using green hydrodistillation technology and used in the development of nanohydrogel. The nanohydrogel displayed good stability and exhibited potential antibacterial activity against pathogenic microorganisms.
FRONTIERS IN CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Fawaz Alasmari, Mohammed S. Alasmari, Mohammed A. Assiri, Mohammed Alswayyed, Syed Rizwan Ahamad, Abdulrahman I. Alhumaydhi, Bandar I. Arif, Sahar R. Aljumayi, Abdullah F. Alasmari, Nemat Ali, Wayne E. Childers, Magid Abou-Gharbia, Youssef Sari
Summary: Fentanyl is a potent opioid analgesic used for pain relief, but its recreational use can cause organ toxicities. A novel experimental compound MC-100093 has been developed to reverse the metabolic changes induced by fentanyl overdose in the liver.
Article
Engineering, Multidisciplinary
Sivakamavalli Jeyachandran, Hethesh Chellapandian, Nemat Ali
Summary: In this study, a Ni-doped ZnO nanocomposite incorporating chitosan was successfully synthesized and its structural, functional, morphological, and porosity properties were comprehensively investigated. The presence of chitosan and nickel in the nanocomposite was confirmed, and their effects on the properties of ZnO nanoparticles were analyzed. The antibacterial and anticancer activities of the prepared nanocomposite were evaluated.
Article
Biochemistry & Molecular Biology
Arunachalam Muthuraman, Abu Sadat Md Sayem, Sakthiganapathi Meenakshisundaram, Nemat Ali, Sheikh F. Ahmad, Abdullah F. Alasmari, Shamama Nishat, Khian Giap Lim, Yamunna Paramaswaran
Summary: The present study investigates the role of beta-carotene in attenuating IS-induced renal dysfunction through regulation of mitochondrial redox balance by BCO2 actions. The findings suggest that BC can alleviate renal damage caused by IS by modulating mitochondrial function.
Article
Multidisciplinary Sciences
Reshmee Bhattacharya, Saakshi Saini, Souvik Ghosh, Partha Roy, Nemat Ali, Mohammad Khalid Parvez, Mohammed S. Al-Dosari, Awdhesh Kumar Mishra, Laishram Rajendrakumar Singh
Summary: Diabetes is a progressive metabolic disease characterized by high blood glucose level. One of its major pathological consequences is the accumulation of advanced glycation end products (AGEs). This study discovered that organosulfurs (S-allyl cysteine and N-acetyl cysteine) found in garlic can inhibit protein glycation and reduce oxidative stress and apoptosis caused by glycation.
SCIENTIFIC REPORTS
(2023)
