Benzimidazole inhibitors of protein kinase CK2 potently inhibit the activity of atypical protein kinase Rio1

Rio1 promotes rDNA stability and downregulates RNA polymerase I to ensure rDNA segregation

(2015) Maria G. Iacovella et al.   Nature Communications

The Ancient Microbial RIO Kinases

(2014) Nicole A. LaRonde   JOURNAL OF BIOLOGICAL CHEMISTRY

Rio1 mediates ATP-dependent final maturation of 40S ribosomal subunits

(2014) Tomasz W. Turowski et al.   NUCLEIC ACIDS RESEARCH

Dominant Rio1 kinase/ATPase catalytic mutant induces trapping of late pre-40S biogenesis factors in 80S-like ribosomes

(2014) Sébastien Ferreira-Cerca et al.   NUCLEIC ACIDS RESEARCH

Development of novel molecular probes of the Rio1 atypical protein kinase

(2013) Marcin Mielecki et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

A Kinome-Wide RNAi Screen in Drosophila Glia Reveals That the RIO Kinases Mediate Cell Proliferation and Survival through TORC2-Akt Signaling in Glioblastoma

(2013) Renee D. Read et al.   PLoS Genetics

Druggability of the CK2 inhibitor CX-4945 as an anticancer drug and beyond

(2012) Jiyeon Kim et al.   ARCHIVES OF PHARMACAL RESEARCH

Modified tetrahalogenated benzimidazoles with CK2 inhibitory activity are active against human prostate cancer cells LNCaP in vitro

(2012) Carolin C. Schneider et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Interaction of Rio1 Kinase with Toyocamycin Reveals a Conformational Switch That Controls Oligomeric State and Catalytic Activity

(2012) Irene N. Kiburu et al.   PLoS One

ATP Site-Directed Inhibitors of Protein Kinase CK2: An Update

(2011) S. Sarno et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

CK2α and CK2α′ subunits differ in their sensitivity to 4,5,6,7-tetrabromo- and 4,5,6,7-tetraiodo-1H-benzimidazole derivatives

(2011) Monika Janeczko et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Pre-clinical characterization of CX-4945, a potent and selective small molecule inhibitor of CK2 for the treatment of cancer

(2011) Fabrice Pierre et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Phosphorylation of thymidylate synthase from various sources by human protein kinase CK2 and its catalytic subunits

(2010) Tomasz Frączyk et al.   BIOORGANIC CHEMISTRY

CX-4945, an Orally Bioavailable Selective Inhibitor of Protein Kinase CK2, Inhibits Prosurvival and Angiogenic Signaling and Exhibits Antitumor Efficacy

(2010) A. Siddiqui-Jain et al.   CANCER RESEARCH

CK2 inhibition induces apoptosis via the ER stress response

(2010) Andrea Hessenauer et al.   CELLULAR SIGNALLING

Protein kinase signaling networks in cancer

(2010) John Brognard et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Tetraiodobenzimidazoles are potent inhibitors of protein kinase CK2

(2009) Alessandra Gianoncelli et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Protein Kinase CK2 in Health and Disease

(2009) N. A. St-Denis et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

AutoDock Vina: Improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading

(2009) Oleg Trott et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

How druggable is protein kinase CK2?

(2009) Giorgio Cozza et al.   MEDICINAL RESEARCH REVIEWS

Improving physical realism, stereochemistry, and side-chain accuracy in homology modeling: Four approaches that performed well in CASP8

(2009) Elmar Krieger et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

The selectivity of inhibitors of protein kinase CK2: an update

(2008) Mario A. Pagano et al.   BIOCHEMICAL JOURNAL

An Unbiased Evaluation of CK2 Inhibitors by Chemoproteomics

(2008) James S. Duncan et al.   MOLECULAR & CELLULAR PROTEOMICS