Article
Neurosciences
Serene Dhawan, Philip Myers, David M. D. Bailey, Aaron D. Ostrovsky, Jan Felix Evers, Matthias Landgraf
Summary: The study reveals the role of reactive oxygen species (ROS) in regulating the size of neuronal dendritic arbors. It shows that activity-regulated ROS are transmitted between cells through NADPH oxidase and aquaporins, ultimately negatively regulating dendritic arbor size.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Review
Biochemistry & Molecular Biology
Tullia Maraldi, Cristina Angeloni, Cecilia Prata, Silvana Hrelia
Summary: This review highlights the role of NOX-derived ROS in stem cell biology and functions, focusing on the positive and negative effects triggered by the activity of different NOX isoforms. Recent findings on downstream molecular targets of NOX-ROS signaling that can modulate stem cell homeostasis and lineage commitment are discussed, along with implications in ex vivo expansion and in vivo engraftment, function, and longevity. The pivotal role of NOX as a regulator of several stem cell populations is underscored, and further studies on the effects of pharmacological modulation of NOX in human stem cells are deemed imperative.
Review
Biochemistry & Molecular Biology
Morgan Salmon
Summary: This review discusses the principles of NADPH oxidase signaling and activation and the effects of NOX signaling mediators in AAAs. It also explores the influence of genetic or pharmacologic inhibitors of NADPH oxidases on experimental pre-clinical AAAs. Experimental evidence suggests that NADPH oxidases may be a promising therapeutic target for developing treatment strategies for AAA management.
Article
Biochemistry & Molecular Biology
Rayan Bou-Fakhredin, Batoul Dia, Hilda E. Ghadieh, Stefano Rivella, Maria Domenica Cappellini, Assaad A. Eid, Ali T. Taher
Summary: Oxidative damage by reactive oxygen species (ROS) is a major contributor to cell injury and tissue damage in thalassemia patients. Recent studies indicate that ROS generation in non-transfusion-dependent (NTDT) patients is a result of iron overload, but the sources of ROS in these patients are still poorly understood. This study found that CYP450 4A and 4F-induced 20-HETE production through an NADPH-dependent pathway mediates reactive oxygen species overgeneration in Hbb(th3/+) mice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Plant Sciences
Xuemei Zhang, Yuanyuan Zong, Di Gong, Lirong Yu, Edward Sionov, Yang Bi, Dov Prusky
Summary: This study investigated the regulatory effects of NADPH oxidase (Nox) genes on the growth and pathogenicity of Penicillium expansum in apple fruits. Mutants of Delta PeNoxA, Delta PeNoxR, and Delta PeRacA genes showed differential effects on the colonization process, with PeRacA demonstrating the strongest regulatory effect. Analysis of ROS content in the mycelium confirmed the functionality of the Nox mutations.
FRONTIERS IN PLANT SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
David Weissman, Christoph Maack
Summary: Heart failure is a growing health burden globally, characterized by alterations in excitation-contraction coupling, cardiac energy deficit, and oxidative stress. While targeting metabolism may provide prognostic benefits, treatments specifically targeting reactive oxygen species (ROS) are still in preclinical stages. More research is needed in this area to develop effective therapies for heart failure.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Review
Immunology
Marta Romo-Gonzalez, Carla Ijurko, Angel Hernandez-Hernandez
Summary: Reactive oxygen species (ROS) have emerged as regulators of cellular signaling and are crucial for the self-renewal capacity of hematopoietic stem cells (HSC). Leukemic stem cells (LSC) and leukemic blasts exhibit different levels of ROS and metabolic capabilities. Oxidative stress and metabolism rewiring are hallmarks of leukemia and have a two-way relationship.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Marc Herb, Alexander Gluschko, Michael Schramm
Summary: Reactive oxygen species (ROS) play important roles in cellular processes but can also lead to diseases, their effects depending on cell type and ROS production conditions. Cellular redox balance, like cell pH and calcium levels, is tightly controlled, with evidence showing that cells regulate ROS production by controlling activation and localization factors.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Cardiac & Cardiovascular Systems
Harry Z. E. Greenberg, Guoan Zhao, Ajay M. Shah, Min Zhang
Summary: Calcific aortic valve disease (CAVD) is a significant cause of cardiovascular morbidity and mortality in western populations. Currently, there are no pharmacological therapies available for CAVD, making it crucial to understand the mechanisms underlying the disease in order to identify novel therapeutic targets.
CARDIOVASCULAR RESEARCH
(2022)
Review
Peripheral Vascular Disease
Patrick J. Pagano, Eugenia Cifuentes-Pagano
Summary: NOXs are a family of proteins that produce reactive oxygen species, found in various cell and organ systems. The evolutionary conservation highlights their importance, with research focusing on their mechanisms of action and role in oxidative stress and disease, starting from their discovery in vasculature. Studies have also used isoform-selective inhibitors to investigate the role of NOX isozymes in vascular biology, particularly in inflammation, pulmonary hypertension, and aging.
Article
Biochemistry & Molecular Biology
Ok-Joo Sul, Seung Won Ra
Summary: The study revealed that quercetin can reduce oxidative stress and inflammation by suppressing NOX2 production, effectively reducing ROS-induced oxidative stress and inflammation.
Article
Hematology
Jung-Min Park, Van Quan Do, Yoon-Seok Seo, Hyun Jong Kim, Joo Hyun Nam, Ming Zhe Yin, Hae Jin Kim, Sung Joon Kim, Kathy K. Griendling, Moo-Yeol Lee
Summary: This study reveals that NOX1 mediates the generation of Ca2+ signals and contributes to vascular contraction and blood pressure elevation induced by Ang II.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2022)
Article
Hematology
Julian Kamhieh-Milz, Lei Chen, Claudia Goettsch, Anna Maria Pfefferkorn, Anja Hofmann, Coy Brunssen, Gregor M. Mueller, Thomas Walther, Muhammad Imtiaz Ashraf, Guido Moll, Henning Morawietz, Janusz Witowski, Rusan Catar
Summary: This study analyzed the mechanism by which NOX2 contributes to Ang II-induced ET-1 production in human microvascular endothelial cells. The results showed that high-fat diet increased the expression of Ang II and ET-1 in wild-type mice, but not in Nox2-deficient mice. In vitro experiments revealed that Ang II promoted NOX2 expression through induction of the Oct-1 protein and increased production of superoxide anions. Inhibition of Oct-1 and superoxide attenuated Ang II-induced ET-1 production.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Review
Pharmacology & Pharmacy
Rachel Njeim, Sahar Alkhansa, Alessia Fornoni
Summary: Diabetic kidney disease (DKD) is a serious complication of diabetes and is often associated with abnormal lipid metabolism and renal accumulation of lipids. Lipids, such as cholesterol, phospholipids, triglycerides, fatty acids, and sphingolipids, play a crucial role in the pathogenesis of DKD. Furthermore, NADPH oxidase-induced production of reactive oxygen species (ROS) is also involved in the development of DKD. This review aims to explore the relationship between lipids and NADPH oxidases, providing insights into the pathogenesis of DKD and potential targeted therapies.
Article
Neurosciences
Brenda Garcia-Hernandez, Julio Moran
Summary: TXNIP is a protein sensitive to oxidant conditions whose expression is related to the progression of death in cancer, diabetes, ischemia, and neurodegenerative diseases, among others. It has been shown that ROS promotes the expression of Txnip through the activation of the FOXO3 transcription factor mediated by Akt inhibition. Additionally, Txnip downregulation decreases neuronal death induced by staurosporine stimulus.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2023)
Article
Endocrinology & Metabolism
Jose Avila-Mendoza, Janeth Mora, Martha Carranza, Maricela Luna, Carlos Aramburo
GENERAL AND COMPARATIVE ENDOCRINOLOGY
(2016)
Article
Endocrinology & Metabolism
Thomas Fleming, Carlos G. Martinez-Moreno, Janeth Mora, Miray Aizouki, Maricela Luna, Carlos Aramburo, Steve Harvey
GENERAL AND COMPARATIVE ENDOCRINOLOGY
(2016)
Article
Biochemistry & Molecular Biology
Rosario Baltazar-Lara, Janeth Mora Zenil, Martha Carranza, Jose Avila-Mendoza, Carlos G. Martinez-Moreno, Carlos Aramburo, Maricela Luna
Summary: This study found that growth hormone (GH) can cross the blood-brain barrier and reach the cerebellum under hypoxic conditions, exerting antiapoptotic, antioxidative, anti-inflammatory, neuroprotective, and neuroregenerative effects. In addition, hypoxia caused changes in the size and structure of cerebellar layers, which could be restored by GH treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)