Article
Endocrinology & Metabolism
Gajanthan Muthuvel, Andrew Dauber, Eirene Alexandrou, Leah Tyzinski, Melissa Andrew, Vivian Hwa, Philippe Backeljauw
Summary: This study aimed to evaluate the efficacy and safety of recombinant human growth hormone (rhGH) therapy for linear growth in children with ACAN deficiency. The results showed that rhGH treatment improved linear growth in these patients and no adverse events related to rhGH were observed.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Neurosciences
Fanyu Zhang, Bo Hua, Tengfei Wang, Mei Wang, Zhong Xiang Ding, Ju-Rong Ding
Summary: Growth hormone deficiency (GHD) is a developmental disorder characterized by short stature, slow growth, and cognitive and behavioral abnormalities due to partial or complete deficiency of growth hormone secreted by the pituitary gland. Research shows abnormal brain functional activity in children with GHD, which may explain their abnormal cognition and behavior.
NEUROSCIENCE LETTERS
(2021)
Review
Endocrinology & Metabolism
Martin O. Savage, Helen L. Storr
Summary: Idiopathic short stature (ISS) is a term used for short children without a known cause; research on GH resistance is important for potentially misclassified children with mild GH resistance.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Neurosciences
Aras Kayvanrad, Stephen R. Arnott, Nathan Churchill, Stefanie Hassel, Aditi Chemparathy, Fan Dong, Mojdeh Zamyadi, Tom Gee, Robert Bartha, Sandra E. Black, Jane M. Lawrence-Dewar, Christopher J. M. Scott, Sean Symons, Andrew D. Davis, Geoffrey B. Hall, Jacqueline Harris, Nancy J. Lobaugh, Glenda MacQueen, Cindy Woo, Stephen Strother
Summary: Quality assurance (QA) is crucial in longitudinal and/or multi-site studies to monitor scanner performance over time and location, detecting and controlling for intrinsic differences and changes in scanner performance. Using phantom scans and QA parameters, variations in image resolution measured by the FWHM were identified as a primary source of variance over time for many sites, as well as between sites and between manufacturers. An unexpected range of instabilities affecting individual slices in a number of scanners were also found, with a preprocessing approach to reduce variance and alleviate anomalies identified.
Article
Neurosciences
Yawen Liu, Haijun Niu, Tingting Zhang, Linkun Cai, Dong Liu, Erwei Zhao, Liang Zhu, PengGang Qiao, Wei Zheng, Pengling Ren, Zhenchang Wang
Summary: This study aimed to explore the association between cardiovascular and spontaneous brain activities during dobutamine infusion in healthy young adults. The results showed that blood pressure and heart rate significantly increased after dobutamine infusion, and there was a decrease in brain functional activity in certain regions. These findings suggest that brain-heart interactions exist in healthy young adults under acute cardiovascular alterations.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Medicine, General & Internal
Su Jin Kim, Min-Sun Kim, Sung Yoon Cho, Byung-Kyu Suh, Cheol Woo Ko, Kee-Hyoung Lee, Han-Wook Yoo, Choong Ho Shin, Jin Soon Hwang, Ho-Seong Kim, Woo Yeong Chung, Chan Jong Kim, Heon-Seok Han, Dong-Kyu Jin
Summary: The study demonstrates that the change in annualized height velocity with Growtropin-II treatment is non-inferior to that with Genotropin treatment in children with short stature born small for gestational age. Growtropin-II is well-tolerated, and has a safety profile comparable with that of Genotropin over a 1-year course of treatment.
Article
Neurosciences
Tao Wang, Xin Huang, Li-xue Dai, Kang-min Zhan, Jun Wang
Summary: Through the use of the PerAF analysis method, we discovered abnormal changes in intrinsic brain activity in several brain regions controlling respiration, vision, memory, language, attention, and emotional control in asthma patients. This helps to characterize the neural mechanisms behind cognitive, sensory, and motor function impairments in asthma patients, providing valuable insights for potential therapeutic targets and disease management strategies.
FRONTIERS IN HUMAN NEUROSCIENCE
(2023)
Article
Endocrinology & Metabolism
Katarzyna Adamczewska, Zbigniew Adamczewski, Andrzej Lewinski, Renata Stawerska
Summary: The study evaluated TSH and FT4 concentrations in children with idiopathic short stature (ISS) and observed that leptin, total cholesterol and LDL-cholesterol levels were significantly higher in obese short children. However, leptin, adiponectin, resistin, TSH and FT4 levels did not differ between subgroups and approximately 7% of children showed elevated TSH levels. The higher the leptin levels, the lower maxGH in clonidine stimulation test was recorded, indicating potential disruptions in hypothalamic signals and inappropriate GH secretion in obese children with ISS.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Pediatrics
Xi Bai, Zhi-Bo Zhou, Xiao-Yuan Guo, Yi-Ling He, Yue-Lun Zhang, Feng-Dan Wang, Feng Feng, Hong-Bo Yang, Shi Chen, Feng-Ying Gong, Hui-Juan Zhu, Hui Pan
Summary: The study aimed to explore the associations between the MRI stages of the knee growth plates and rhGH response in short-stature children in late puberty. The results showed that the MRI stages of growth plates were significantly correlated with growth velocity and height gain after therapy, especially when grouped by proximal tibias. This MRI staging method may serve as an effective tool for predicting rhGH response in this population.
WORLD JOURNAL OF PEDIATRICS
(2023)
Article
Neurosciences
Tamara Vasilkovska, Mohit H. Adhikari, Johan Van Audekerke, Somaie Salajeghe, Dorian Pustina, Roger Cachope, Haiying Tang, Longbin Liu, Ignacio Munoz-Sanjuan, Annemie Van der Linden, Marleen Verhoye
Summary: Huntington's disease is caused by a mutation in the huntingtin gene, leading to neurodegeneration and dysfunction in the brain's large-scale networks. This study used resting-state fMRI to investigate changes in functional connectivity in a mouse model of Huntington's disease at different ages. The results show that connectivity alterations start with cortical networks and later affect striatal connectivity.
NEUROBIOLOGY OF DISEASE
(2023)
Article
Endocrinology & Metabolism
Lukas Plachy, Shenali Anne Amaratunga, Petra Dusatkova, Klara Maratova, Vit Neuman, Lenka Petruzelkova, Dana Zemkova, Barbora Obermannova, Marta Snajderova, Stanislava Kolouskova, Zdenek Sumnik, Jan Lebl, Stepanka Pruhova
Summary: The genetic etiology of short stature in children with diagnosed growth hormone deficiency (GHD) was studied. It was found that the primary cause of short stature in these children was growth plate disorders, not deficiency in growth hormone.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Huahong Wu, Yang Li, Hui Li
Summary: This study analyzed the prevalence of BDA3 in children with short stature and its effect on GH therapy. The results showed that BDA3 is more common in the short stature group, with a predominance in females. BDA3 occurrence is independent of the GH pathway and does not affect the therapeutic effect of GH on short stature children.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Behavioral Sciences
Zhaoxian Li, Yuwen Li, Xianrui Li, Feng Zou, Yufeng Wang, Xin Wu, Yanyan Luo, Meng Zhang
Summary: Recent studies have shown a growing association between disgust and various psychopathologies. By analyzing the spontaneous brain activity patterns associated with disgust sensitivity, researchers aim to gain insight into the neurological nature of disgust and its vulnerability to psychopathologies. The findings suggest that specific brain regions and network patterns are closely linked to levels of disgust sensitivity, providing valuable evidence for understanding the neurological basis of disgust sensitivity and its connection to psychopathology.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Endocrinology & Metabolism
Hyun Wook Chae, Il-Tae Hwang, Ji-Eun Lee, Cheol Hwan So, Young-Jun Rhie, Jung Sub Lim, Eun Byul Kwon, Kyung Hee Yi, Eun Young Kim, Chae-Ku Jo, Kye Shik Shim, Ha-Yeong Gil, Min-Jeong Seong, Chung Mo Nam, Ji-Su Moon, Jin Soon Hwang
Summary: This study aimed to investigate the height development of ISS patients in Korea who received GH treatment. The study found that starting treatment at an early age and using automatic pen or electronic devices can increase the likelihood of reaching the target height.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Neurosciences
Bruno Hebling Vieira, Julien Dubois, Vince D. Calhoun, Carlos Ernesto Garrido Salmon
Summary: Predicting general intelligence from resting-state functional magnetic resonance imaging signals using an ensemble of recurrent neural networks and temporal variance of saliencies provides more reliable results than traditional approaches. The model's reliance on network size is a key factor, and the method allows for testing the effects of local alterations on data and derived metrics.
HUMAN BRAIN MAPPING
(2021)