Article
Neurosciences
Sebastiaan De Schepper, Judy Z. Z. Ge, Gerard Crowley, Lais S. S. Ferreira, Dylan Garceau, Christina E. E. Toomey, Dimitra Sokolova, Javier Rueda-Carrasco, Sun-Hye Shin, Jung-Seok Kim, Thomas Childs, Tammaryn Lashley, Jemima J. J. Burden, Michael Sasner, Carlo Sala Frigerio, Steffen Jung, Soyon Hong
Summary: Microglia mediate aberrant synapse engulfment in Alzheimer's disease (AD), but the underlying mechanisms are poorly understood. Here the authors show a perivascular cells-to-microglia crosstalk that induces microglia phagocytic state resulting in synapse engulfment in two mouse models of AD.
NATURE NEUROSCIENCE
(2023)
Article
Multidisciplinary Sciences
Filip Stojanovic, Mariam Taktek, Nam Huan Khieu, Junzhou Huang, Susan Jiang, Kerry Rennie, Balu Chakravarthy, Will J. Costain, Miroslava Cuperlovic-Culf
Summary: Metabolomics studies in Alzheimer's disease have shown major changes in metabolic profiles of patients, but distinguishing causes and consequences is difficult at late stages of the disease. Analysis of the APP/PS1 mouse model has revealed metabolic changes in response to plaque formation, suggesting that early treatment and prevention strategies should focus on metabolic changes observed in humans rather than mice.
Article
Multidisciplinary Sciences
Prokopis C. Prokopiou, Nina Engels-Dominguez, Kathryn Papp, Matthew R. Scott, Aaron P. Schultz, Christoph Schneider, Michelle E. Farrell, Rachel F. Buckley, Yakeel T. Quiroz, Georges El Fakhri, Dorene M. Rentz, Reisa A. Sperling, Keith A. Johnson, Heidi I. L. Jacobs
Summary: Cortical Alzheimer's Disease neuropathology is associated with cognitive decline, and the functional properties of the locus coeruleus (LC) can be used to identify individuals at risk for the disease.
NATURE COMMUNICATIONS
(2022)
Article
Chemistry, Multidisciplinary
Fei Zhu, Wenqian Wang, Fan Zhang, Manivannan Kalavathi Dhinakaran, Yingqian Wang, Rui Wang, Jing Cheng, Maria Eugenia Toimil-Molares, Christina Trautmann, Haibing Li
Summary: In this study, tryptophan enantiomers were utilized in artificial nanochannels to regulate the chiral selective transport of A beta proteins, with l-Trp channel showing effective selectivity for the transportation of A beta proteins. This could offer a new perspective for pathological studies of Alzheimer's disease.
CHEMICAL COMMUNICATIONS
(2021)
Review
Biochemistry & Molecular Biology
Thomas Gabriel Schreiner, Manuel Menendez-Gonzalez, Bogdan Ovidiu Popescu
Summary: Alzheimer's disease is a global health problem with no effective treatment currently available. A new approach based on amyloid-beta dynamics, known as the cerebrospinal-fluid-sink therapeutic strategy, offers promising solutions with significant therapeutic impact.
Article
Biochemistry & Molecular Biology
Ivan Alic, Pollyanna A. Goh, Aoife Murray, Erik Portelius, Eleni Gkanatsiou, Gillian Gough, Kin Y. Mok, David Koschut, Reinhard Brunmeir, Yee Jie Yeap, Niamh L. O'Brien, Jurgen Groet, Xiaowei Shao, Steven Havlicek, N. Ray Dunn, Hlin Kvartsberg, Gunnar Brinkmalm, Rosalyn Hithersay, Carla Startin, Sarah Hamburg, Margaret Phillips, Konstantin Pervushin, Mark Turmaine, David Wallon, Anne Rovelet-Lecrux, Hilkka Soininen, Emanuela Volpi, Joanne E. Martin, Jia Nee Foo, David L. Becker, Agueda Rostagno, Jorge Ghiso, Zeljka Krsnik, Goran Simic, Ivica Kostovi, Dinko Mitrecic, Paul T. Francis, Kaj Blennow, Andre Strydom, John Hardy, Henrik Zetterberg, Dean Nizetic
Summary: Research has shown that individuals with Down Syndrome exhibit Alzheimer's disease-like pathological changes, which can be successfully replicated in vitro cerebral organoids models. These findings suggest that DS cerebral organoids could serve as a potential detector for pre-morbid AD-risk populations, as well as a system for hypothesis-free drug screening and identification of natural suppressor genes for neurodegenerative diseases.
MOLECULAR PSYCHIATRY
(2021)
Article
Medicine, General & Internal
Yunyan Xie, Qin Yang, Chunhua Liu, Qi Zhang, Jiehui Jiang, Ying Han
Summary: The study aimed to identify a pattern associated with beta-amyloid deposition during cognitively normal healthy aging. Analysis of PET brain images revealed a specific pattern of A beta deposition primarily in certain brain regions, showing a significant positive correlation with age and potential for distinguishing physiological from pathological changes.
FRONTIERS IN MEDICINE
(2021)
Article
Clinical Neurology
David W. Nauen, Juan C. Troncoso
Summary: The research examined lymph nodes resected during cancer treatment or staging and found that Aβ-labeled cells were present, with cervical lymph nodes having more labeled cells than inguinal nodes. This observation supports the hypothesis that the glymphatic system contributes to the clearance of Aβ from the human brain.
ALZHEIMERS & DEMENTIA
(2022)
Review
Clinical Neurology
Louise Kelly, Christopher Brown, Daniel Michalik, Cheryl A. Hawkes, Roxana Aldea, Nivedita Agarwal, Rami Salib, Aiman Alzetani, Douglas W. Ethell, Scott E. Counts, Mony de Leon, Silvia Fossati, Maya Koronyo-Hamaoui, Fabrizio Piazza, Steven A. Rich, Frank J. Wolters, Heather Snyder, Ozama Ismail, Fanny Elahi, Steven T. Proulx, Ajay Verma, Hilary Wunderlich, Mareike Haack, Jean Cosme Dodart, Norman Mazer, Roxana O. Carare
Summary: This editorial summarizes the advances and objectives of the CLIC group within the Vascular PIA of ISTAART, focusing on understanding the physiological changes underlying impaired clearance of interstitial fluid and cerebrospinal fluid, investigating the mechanisms of intramural periarterial drainage, establishing novel diagnostic tests, and developing therapies to prevent and reduce Alzheimer's disease and cerebral amyloid angiopathy.
ALZHEIMERS & DEMENTIA
(2023)
Review
Neurosciences
Telma Quintela, Andre Furtado, C. Ana Duarte, Isabel Goncalves, Jihwan Myung, R. A. Cecilia Santos
Summary: Recent studies have shown that choroid plexus epithelial cells possess a circadian clock system that may regulate various functions important for brain homeostasis. Functions such as cerebrospinal fluid secretion, clearance of amyloid-beta peptides and xenobiotics, and the barrier function of the blood-cerebrospinal fluid barrier are all influenced by the circadian clock. This highlights the importance of considering circadian regulation for drug delivery to central nervous system disorders.
PROGRESS IN NEUROBIOLOGY
(2021)
Article
Cell Biology
Gai Ayalon, Seung-Hye Lee, Oskar Adolfsson, Corinne Foo-Atkins, Jasvinder K. Atwal, Mira Blendstrup, Helen Booler, Joseph Bravo, Robert Brendza, Flavia Brunstein, Ruby Chan, Priya Chandra, Jessica A. Couch, Akash Datwani, Barthelemy Demeule, Danielle DiCara, Rich Erickson, James A. Ernst, Oded Foreman, Dongping He, Isidro Hotzel, Michael Keeley, Michael C. M. Kwok, Julien Lafrance-Vanasse, Han Lin, Yanmei Lu, Wilman Luk, Paul Manser, Andreas Muhs, Hai Ngu, Andrea Pfeifer, Maria Pihlgren, Gautham K. Rao, Kimberly Scearce-Levie, Stephen P. Schauer, William B. Smith, Hilda Solanoy, Edmond Teng, Kristin R. Wildsmith, Daniela Bumbaca Yadav, Yong Ying, Reina N. Fuji, Geoffrey A. Kerchner
Summary: Tau has become an attractive alternative target for passive immunotherapy efforts in Alzheimer's disease. The humanized anti-tau monoclonal antibody Semorinemab shows clear evidence of target engagement, protecting neurons against tau toxicity and binding all six human tau isoforms.
SCIENCE TRANSLATIONAL MEDICINE
(2021)
Review
Clinical Neurology
Juan Fortea, Shahid H. Zaman, Sigan Hartley, Michael S. Rafii, Elizabeth Head, Maria Carmona-Iragui
Summary: Adults with Down syndrome are at high risk of developing early-onset dementia, which is the leading cause of death in this population. Diagnosis of dementia remains a challenge due to lack of validated criteria, and biomarkers have shown good diagnostic performances with similar changes to Alzheimer's disease. Despite the lack of treatments to prevent Alzheimer's, unprecedented research in this area may lead to disease-modifying therapies.
Article
Pharmacology & Pharmacy
Naveed Ullah Khan, Jiang Ni, Xiufeng Ju, Tongtong Miao, Haiyan Chen, Liang Han
Summary: Breast cancer brain metastases (BCBMs) are challenging due to their intracranial location and limited response to chemotherapy. Research has shown promising results with nanoparticles (NPs-K-s-A) targeting LRP1 and MMP1 to overcome the blood-brain barrier and enhance drug delivery, leading to improved therapeutic outcomes in mice with BCBMs. This fusion peptide-based drug delivery strategy shows potential for clinical management of BCBMs.
ACTA PHARMACEUTICA SINICA B
(2021)
Review
Radiology, Nuclear Medicine & Medical Imaging
Jesse M. Klostranec, Diana Vucevic, Kartik D. Bhatia, Hans G. J. Kortman, Timo Krings, Kieran P. Murphy, Karel G. TerBrugge, David J. Mikulis
Summary: The glymphatic system plays a crucial role in maintaining extracellular conditions in the central nervous system, serving as a pathway for fluid transport and exchange. Its discovery has enhanced our understanding of neurophysiology and may be helpful for radiologists in interpreting neuroimaging investigations.
Article
Pharmacology & Pharmacy
Beatrice Paola Festa, Antonio Daniel Barbosa, Matea Rob, David C. Rubinsztein
Summary: Autophagy is a vital pathway for clearing toxic protein aggregates, playing a crucial role in the pathology of Alzheimer's disease. The increased levels of autophagosomes in patients' brains may be associated with the disease, while autophagy is also involved in regulating inflammation, further driving pathogenesis.
CURRENT OPINION IN PHARMACOLOGY
(2021)
